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Application of citral in inhibiting growth of multi-drug resistant enterobacter cloacae

A technology of Enterobacter cloacae and Enterobacter cloacae is applied in the application field of citral in inhibiting the growth of multi-drug-resistant Enterobacter cloacae, which can solve problems such as undiscovered research reports, achieve reduction of fatality rate, wide application value, and solution to resistance Effects of drug infection problems

Active Publication Date: 2019-09-27
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, research reports on citral inhibiting Enterobacter cloacae have not been found

Method used

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  • Application of citral in inhibiting growth of multi-drug resistant enterobacter cloacae
  • Application of citral in inhibiting growth of multi-drug resistant enterobacter cloacae
  • Application of citral in inhibiting growth of multi-drug resistant enterobacter cloacae

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Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0016] 1. Drug susceptibility test of human Enterobacter cloacae

[0017] The present invention uses 3 strains of human-derived Enterobacter cloacae as starting strains (strain samples are taken from the General Hospital of the Chinese People's Liberation Army), and selects cefazolin, cefotaxime, bromogmentine, meropenem, ofloxacin, and levofloxacin , ciprofloxacin, cefoxetine, minocycline, imipenem, piperacillin, azithromycin, nitrofurantoin, gentamicin and other 16 kinds of antibiotic susceptibility test strips for drug susceptibility test.

[0018] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptica...

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Abstract

The invention discloses an application of citral in inhibiting growth of multi-drug resistant enterobacter cloacae. The citral can inhibit growth of multi-drug resistant enterobacter cloacae as the citral has relatively good in vitro killing action to multi-drug resistant enterobacter cloacae resisting cefazolin, cefotaxime, augmentin, meropenem, ofloxacin, levofloxacin, ciprofloxacin, cefoxitin, minocyline, imipenem, piperacillin, azithromycin, macrodantin, sulfamethoxazole and nalidixic acid. The minimum bactericidal concentration is 1.6 mg / mL and the minimal inhibitory concentration is 1.0 mg / mL. The invention provides inhibiting action of citral to multi-drug resistant enterobacter cloacae and the citral has wide application value in the field of medicine.

Description

technical field [0001] The invention relates to the research, development and application of citral, an active ingredient of traditional Chinese medicine, as a bacterial inhibitor, in particular to the application of citral in inhibiting the growth of multidrug-resistant Enterobacter cloacae. Background technique [0002] Enterobacter cloacae (Enterobacter cloacae) belongs to Enterobacteriaceae, widely exists in nature, and is distributed in human and animal feces, water, soil, and plants. Enterobacter cloacae can cause multi-system infection, and can also cause sepsis, urinary tract infection, wound infection and urinary tract infection, etc. Due to the widespread use of β-lactam antibiotics, the drug resistance of Enterobacter cloacae is becoming more and more serious, and it can form resistant Drug strains, even multi-drug resistant strains (β-lactamase-producing), Enterobacter cloacae as an opportunistic pathogen has become one of the main pathogenic bacteria in hospital...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/11A61P31/04
CPCA61K31/11A61P31/04
Inventor 钱卫东沈兰芳王婷刘淼张家宁杨敏孙照欢李鑫辰
Owner SHAANXI UNIV OF SCI & TECH
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