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L-menthol slow-release material based on graphene quantum dots and preparation method thereof

A sustained-release material, menthol technology, applied in the field of L-menthol sustained-release material and its preparation, can solve the problems of cumbersome operation, large microcapsule particle size, low bioavailability, etc., achieve simple industry, low cost, The effect of easy access to raw materials

Active Publication Date: 2019-09-06
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the industrial production of these methods is cumbersome, and the prepared microcapsules have a large particle size and low bioavailability.

Method used

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  • L-menthol slow-release material based on graphene quantum dots and preparation method thereof
  • L-menthol slow-release material based on graphene quantum dots and preparation method thereof
  • L-menthol slow-release material based on graphene quantum dots and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Preparation of amphiphilic long-chain alkylamine functionalized graphene quantum dots:

[0049] 0.96g citric acid (5.0mmol), 0.060g 1-dodecylamine (0.3mmol) and ammonia water (0.04mL) were dissolved in ultrapure water (10mL), the mixed solution was transferred to a 20mL autoclave, put into an oven , thermally cracked at 180 °C for 3 h, and cooled to room temperature. Use 0.5mol·L -1 Adjusted to pH 7 with NaOH, prepared with water to 0.06 mg L -1 The solution was filtered through a 0.22 μm filter membrane, and then dialyzed in a dialysis bag with a molecular weight cut-off of 3 kDa for 24 h to obtain a quantum dot stock solution, which was freeze-dried to obtain a DA-GQD solid.

[0050] (2) Utilize Pickering emulsion method to prepare L-menthol sustained-release material:

[0051] Disperse 1.0 g of DA-GQD in 100 mL of water (1% aqueous solution), place it in a centrifuge tube, add 0.5 mL of pre-heated L-menthol, homogenize at 10,000 rpm for 2 min to obtain Pickeri...

Embodiment 2

[0063] Example 2 Influence of different functionalized graphene quantum dots on the obtained sustained-release material

[0064] Referring to Example 1, dodecylamine was respectively replaced with the functionalized reagent shown in Table 1, and other conditions were unchanged, and L-menthol sustained-release material was prepared.

[0065] Table 1 Results of different functionalized graphene quantum dots on the obtained sustained-release materials

[0066]

Embodiment 3

[0067] Example 3 Influence of different mass concentrations of graphene quantum dots on slow-release materials in aqueous phase

[0068] Referring to Example 1, the dosage of dodecylamine quantum dots was replaced with the dosage shown in Table 2, and other conditions remained unchanged, and the L-menthol sustained-release material was prepared.

[0069] Table 2 Results of different functionalized graphene quantum dots on the obtained sustained-release materials

[0070]

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Abstract

The invention discloses an L-menthol slow-release material based on graphene quantum dots and a preparation method thereof, which belong to the field of slow release materials. The method utilizes functionalized graphene quantum dots as a particle emulsifier, and the functionalized graphene quantum dots are dispersed at a menthol / water interface to form a Pickering emulsion; the L-menthol is covered by small graphite sheets, and L-menthol supported by the sustained-release material obtained after cooling and crystallization has good sustained-release properties. The method of the invention hasthe advantages of simple process, effective and high loading of L-menthol can be realized, and effective sustained release is realized; the method achieves low cost and industrial production, and theobtained L-menthol sustained-release material can be used in the fields of food, tobacco, daily chemical and medicine.

Description

technical field [0001] The invention relates to a graphene quantum dot-based L-menthol sustained-release material and a preparation method thereof, belonging to the field of sustained-release materials. Background technique [0002] L-menthol (L-menthol) is the main component of natural peppermint oil, which can be extracted from natural peppermint oil. L-Menthol is a colorless columnar or needle-like crystal, which is volatile and not durable, and is easy to sublime when exposed to air. Due to its strong cooling effect, L-menthol is widely used as food additives, tobacco flavoring agents, daily chemical flavoring agents and medicines. In applications, L-menthol is often used as an additive to be directly dissolved or mechanically mixed into a matrix, such as toothpaste, chewing gum, and drugs. However, due to the high volatility of L-menthol, the release rate is too fast and the durability is poor during use. It is necessary to develop a new preparation process to improve...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/19A61K8/34A61K9/107A61K47/04A61K47/10A23L29/00A24B3/12
CPCA24B3/12A61K8/06A61K8/19A61K8/34A61K9/0004A61K9/107A61K47/02A61K47/10A61K2800/412A23L29/04
Inventor 李明李在均
Owner JIANGNAN UNIV
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