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Modified nano-hydroxyapatite supramolecular composite hydrogel and preparation method thereof

A nano-hydroxyapatite and composite hydrogel technology is applied in the field of biomedical composite materials, which can solve the problems of limited application and difficult composite, and achieve the effects of improving mechanical properties, easy preparation and excellent biocompatibility.

Active Publication Date: 2019-08-02
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its difficulty in complexing with active biological factors also limits its application in the field of bone repair

Method used

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  • Modified nano-hydroxyapatite supramolecular composite hydrogel and preparation method thereof
  • Modified nano-hydroxyapatite supramolecular composite hydrogel and preparation method thereof
  • Modified nano-hydroxyapatite supramolecular composite hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Dissolve 121.1 g tris (1 mmol) in 10 mL deionized water, then dilute it 10 times to make a 10 mM buffer solution, add 1 mM dilute hydrochloric acid to adjust the pH of the buffer solution to 8.4. 120mg dopamine (0.78mmol) was dissolved in 30mL buffer solution, then 200mg nano-hydroxyapatite (0.2mmol) was added in dopamine buffer solution, stirred and reacted for 16 hours, then the product obtained after the reaction was centrifuged, washed, After drying, the dried product was washed with ethanol, centrifuged and then vacuum-dried to obtain hydroxyapatite (DOP-nHA) with dopamine on the surface.

[0031] (2) 200 mg (0.04 mmol) of methoxypolyethylene glycol amine (PEG-NH) with a molecular weight of 5000 Da 2 ) was dissolved in 1mL deionized water, then 40mg (0.04mmol) DOP-nHA was added to the solution, and stirred at room temperature for 16 hours. After the reaction, the product was centrifuged, washed, and vacuum-dried to obtain PEG-modified nano-hydroxyphosphorus Li...

Embodiment 2

[0034] (1) Dissolve 121.1 g tris (1 mmol) in 10 mL deionized water, then dilute it 10 times to make a 10 mM buffer solution, add 1 mM dilute hydrochloric acid to adjust the pH of the buffer solution to 8.4. 180mg dopamine (1.18mmol) was dissolved in 30mL buffer solution, then 400mg nano-hydroxyapatite (0.4mmol) was added in dopamine buffer solution, stirred and reacted for 24 hours, then the product obtained after the reaction was centrifuged, washed, After drying, the dried product was washed with ethanol, centrifuged and then vacuum-dried to obtain hydroxyapatite (DOP-nHA) with dopamine on the surface.

[0035] (2) 300 mg (0.06 mmol) of methoxypolyethylene glycol amine (PEG-NH) with a molecular weight of 5000 Da 2 ) was dissolved in 1mL deionized water, then 30mg (0.03mmol) DOP-nHA was added to the solution, and stirred at room temperature for 24 hours. After the reaction, the product was centrifuged, washed, and vacuum-dried to obtain PEG-modified nano-hydroxyphosphorus Li...

Embodiment 3

[0038](1) Dissolve 121.1g tris (0.001mol) in 10mL deionized water, then dilute it 10 times to make a 10mM buffer solution, add 1mM dilute hydrochloric acid to adjust the pH of the buffer solution to 8.4. 150mg dopamine (0.98mmol) was dissolved in 30mL buffer solution, then 300mg nano-hydroxyapatite (0.3mmol) was added in the dopamine buffer solution, stirred and reacted for 36 hours, and the product obtained after the reaction was centrifuged, washed, After drying, the dried product was washed with ethanol, centrifuged and then vacuum-dried to obtain hydroxyapatite (DOP-nHA) with dopamine on the surface.

[0039] (2) 300 mg (0.06 mmol) of methoxypolyethylene glycol amine (PEG-NH) with a molecular weight of 5000 Da 2 ) was dissolved in 1mL deionized water, then 20mg (0.02mmol) DOP-nHA was added to the solution, and stirred at room temperature for 36 hours. After the reaction, the product was centrifuged, washed, and vacuum-dried to obtain PEG-modified nano-hydroxyphosphorus Li...

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Abstract

The invention belongs to the field of biomedical composite materials and discloses a modified nano-hydroxyapatite supramolecular composite hydrogel and a preparation method thereof. The preparation method comprises the following steps: modifying natural molecule dopamine to the surface of nanometer hydroxyapatite through in-situ polymerization, grafting polyethylene glycol to the dopamine-coated nanometer hydroxyapatite through Schiff base reaction, simply blending a polyethylene glycol-grafted hydroxyapatite turbid liquid and an alpha-cyclodextrin aqueous solution for self-assembly to obtainthe modified nano-hydroxyapatite supramolecular composite hydrogel for bone repair. The preparation method of the composite hydrogel has the advantages that a synthetic route is simple, and the gelation process is easy to operate. Through regulating the proportion of the nanometer hydroxyapatite, the mechanical properties of the hydrogel can also be regulated, so that the hydrogel can adapt to a wider range of biomedical applications.

Description

technical field [0001] The invention belongs to the field of biomedical composite materials, and in particular relates to a modified nano-hydroxyapatite supramolecular composite hydrogel and a preparation method thereof. Background technique [0002] Nano-hydroxyapatite (nHA) is the main inorganic component in human bones. It is a weakly alkaline calcium phosphate salt that is slightly soluble in water. Its chemical formula is [Ca 10 (PO 4 ) 6 (OH) 2 , hydroxyapatite, HA], Ca / P is 1.67, consistent with Ca / P in natural bone. Because hydroxyapatite has good biocompatibility, biodegradability and good osteogenesis ability, it is widely used as bone tissue engineering material. However, its difficulty in complexing with active biological factors also limits its application in the field of bone repair. [0003] Hydrogel is a polymer material with a three-dimensional network structure similar to biological soft tissue. It has good swelling properties, biocompatibility and hig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/16C08K9/04C08K3/32A61L27/52A61L27/46
CPCA61L27/46A61L27/52A61L2300/412C08J3/075C08J3/24C08J2305/16C08K9/04C08K9/08C08K2003/321C08K2201/011C08L5/16
Inventor 任力贾永光严迪威莫丽娜刘卅
Owner SOUTH CHINA UNIV OF TECH
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