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Anticoccidial drug decoquinate solution and preparation method thereof

A technology of decoquinate and anticoccidia, which is applied in the field of anticoccidial drug decoquinate solution and its preparation, can solve problems such as poor therapeutic effect, achieve convenient administration, facilitate large-scale industrial production, and preparation method simple effect

Inactive Publication Date: 2019-08-02
河南健恒动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem in the prior art that the intake of the decoquinate premix is ​​difficult to control leading to poor therapeutic effect, the present invention provides an anticoccidial drug decoquine which is easy to control the dose and has better absorption effect. Ester solution and its preparation method

Method used

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  • Anticoccidial drug decoquinate solution and preparation method thereof
  • Anticoccidial drug decoquinate solution and preparation method thereof
  • Anticoccidial drug decoquinate solution and preparation method thereof

Examples

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Embodiment

[0020] Weigh according to the mass percentage of each component shown in Examples 1-4 in Table 1, mix absolute ethanol, dimethylformamide, polyethylene glycol 200 and magnesium chloride, heat to 80°C; add decoquine Esters, stirred for 30 minutes, dissolved to obtain a yellow clear solution; then added Tween-80, stirred for 10 minutes; after the solution was cooled to room temperature, added ethanolamine to adjust the pH; filtered and packed separately.

[0021] The ratio of each component of the decoquinate solution of table 1 embodiment 1-4

[0022]

[0023]

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Abstract

The invention provides an anticoccidial drug decoquinate solution. Based on the total mass of various components being 100%, the decoquinate solution is prepared from the following components in percentage by mass: 3% of decoquinate, 9-13% of absolute ethyl alcohol, 65-72% of dimethylformamide, 5-9% of polyethylene glycol 200, 6% of Tween-804, 3-7% of ethanol amine and 2-7% of magnesium chloride.The decoquinate solution can be mixed with water for drug administration, an absorbing effect is good, and a relatively good anticoccidial effect is achieved.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to an anticoccidial drug decoquinate solution and a preparation method thereof. Background technique [0002] The chemical name of decoxyquinate is 6-decyloxy-7-ethoxyl-4-hydroxyquinoline-3-carboxylic acid ethyl ester, which has spectrum anticoccidial activity and is used to prevent various coccidiosis Poultry coccidiosis caused by bit, tender, giant, heap type, poisonous and Brucella, etc.). Decoxyquinate plays a role in the asexual reproduction stage of coccidia. After entering the spore cells of coccidia, it prevents its development by interfering with DNA synthesis, and starts to play a role in the early life cycle of coccidia, so as to avoid damage to the intestinal tract of poultry. Decoxyquinate has low toxicity and good tolerance. It is still safe to use 80 times the recommended dose, and it metabolizes quickly. After 3 days of drug withdrawal, the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/47A61K47/10A61K47/18A61P33/02
CPCA61K9/0095A61K9/08A61K31/47A61K47/10A61K47/18A61P33/02
Inventor 朱红标王申锋赵文刚
Owner 河南健恒动物药业有限公司
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