Amino acid type chelating agent as well as large-scale preparation method and application thereof

An amino acid type, chelating agent technology, applied in chemical instruments and methods, cyanide reaction preparation, preparation of organic compounds, etc., can solve the problems of many risk substances, ecological environment impact, operator's personal safety threat, etc., to achieve the process flow Simple, high reaction efficiency, low production cost

Inactive Publication Date: 2019-06-21
NANJING HUASHI NEW MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] The characteristic of this route is that the cost of raw materials is relatively low, but the disadvantages are also obvious: multi-step use of highly toxic chemicals such as cyanide, formaldehyde, acetaldehyde, etc., no separation process, and more side reactions and impurities, which must remain in the In the product, the quality of the product is difficult to control
[0025] To sum up, the Strecker process is characterized by the use of cheap formaldehyde, cyanide, and ammonia as raw materials, and even some raw materials are industrial by-products, so it has certain advantages in cost control of raw materials, but the disadvantages are also very obvious. Raw materials are highly toxic and do great harm to the human body and the ecological environment
[0026] Due to the large-scale manufacturing of the Strecker method, highly toxic, carcinogenic, teratogenic, and mutagenic substances are used as raw materials, which pose a huge threat to the personal safety of operators; the production process will produce toxic waste residues, waste liquids, and volatile substances. The external ecological environment will have a serious impact; in terms of product quality, due to the risk of highly toxic substance residues and harmful by-products, its quality is difficult to guarantee
In addition, a very important point is that the Stretcher method in the prior art uses a one-pot method of highly toxic substances, without intermediate separation and purification processes, and there are many risky substances, and the product has a huge safety risk

Method used

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  • Amino acid type chelating agent as well as large-scale preparation method and application thereof
  • Amino acid type chelating agent as well as large-scale preparation method and application thereof
  • Amino acid type chelating agent as well as large-scale preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The preparation method of embodiment 1 sodium methylamine diacetate

[0064] Feeding amount:

[0065] raw material name mass (g) Sodium Sarcosinate (40%) 277.5 sodium iodide 0.2 water 75 Chloroacetic acid (solid) 99.3 Sodium Hydroxide (50%) 104.0

[0066] Reaction equation:

[0067]

[0068] Specific experimental process:

[0069] Into a 500mL reaction flask, add 75.0kg of water, 99.3g of chloroacetic acid, 0.2g of sodium iodide, and 277.5g of sodium sarcosinate aqueous solution (m / m=40%) in sequence, stir at room temperature for 1.0h, and then heat up to 55.0 ℃, add 104.0g sodium hydroxide aqueous solution (m / m=50.0%) dropwise, and keep the pH value at 8.5-9.0. After all the addition is completed, continue stirring at this temperature for 30.0 minutes, and then raise the temperature to 90.0℃ for 4.0h of heat preservation reaction. After the reaction was completed, the temperature was cooled to room temperature, and a ...

Embodiment 2

[0071] Example 2 The preparation method of trisodium 2-ethylglycine diacetate

[0072] Feeding amount:

[0073] raw material name mass (g) 2-aminobutyric acid 103.1 sodium iodide 0.5 water 260.0 Chloroacetic acid (70%) 303.6 Sodium Hydroxide (50%) 342.0

[0074] Reaction equation:

[0075]

[0076] Specific experimental process:

[0077] Into a 1000L three-necked reaction flask, sequentially add 260.0g of water, 103.1g of 2-aminobutyric acid, 0.5g of sodium iodide, stir at room temperature for 1.0h, then raise the temperature to 40.0°C, and dropwise add 342.0g of sodium hydroxide aqueous solution (m / m=50.0%), after 5 minutes, start to drop 303.6g aqueous solution of chloroacetic acid (m / m=70%), keep the temperature at 40-50°C, after about 5.0h all added, continue to stir at this temperature for 5h, then Raise the temperature to 92.0°C for 3.0 hours of heat preservation reaction. After the reaction, cool down to room temperat...

Embodiment 3

[0079] The preparation method of embodiment 3 beta-alanine diacetate trisodium

[0080] Feeding amount:

[0081] raw material name mass (g) beta-alanine 89.1 sodium iodide 0.2 water 260.0 Chloroacetic acid (70.0%) 303.6 Sodium Hydroxide (50%) 342.0

[0082] Reaction equation:

[0083]

[0084] Specific experimental process:

[0085] Into a 1000mL three-neck flask, add 250g of deionized water, 89.1g of β-alanine, and 0.2g of sodium iodide in sequence, turn on magnetic stirring, and dropwise add lye (m / m=50.0%) to adjust the pH value to 9.0-9.5, Stir at this temperature for 1.0h, then raise the temperature to 55.0°C, while adding dropwise the remaining aqueous sodium hydroxide solution (m / m=50.0%), and after 5 minutes, add dropwise 212.6g aqueous solution of chloroacetic acid (m / m=70.0%) ), keep the temperature at 45.0-50.0°C, complete the addition in about 4.5h, continue to stir at this temperature for 5.0h, then raise the tem...

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Abstract

The invention provides degradable amino acid type chelating agent composition suitable for large-scale industrial production and a preparation method of the degradable amino acid type chelating agentcomposition. Amino acid, haloacetic acid and alkali in an aqueous solution are subjected to a reaction at reaction temperature of 40-120 DEG C in a regulated pH range of 8-13 under the action of an iodide catalyst, and after the reaction, the amino acid type chelating agent composition is obtained. The method has the characteristics of being safe, efficient and free of amplification effect, containing fewer impurities and facilitating realization of large-scale production; the raw materials are easily available, and reaction yield is high; an obtained product has better application performance. The invention further provides an application of the composition as a chelating agent in the fields of daily chemicals, food, agriculture, forestry, papermaking, textile, printing and dyeing, watertreatment, coal and the like.

Description

technical field [0001] The invention relates to an amino acid chelating agent, its large-scale production method, and its application as a chelating agent and antiseptic enhancer in the fields of daily chemicals, food, agriculture, forestry, papermaking, textiles, printing and dyeing, water treatment, coal, etc. . Background technique [0002] Traditional chelating agents such as phosphates, nitrilotriacetic acid (NTA), sodium ethylenediaminetetraacetic acid (EDTA), and diethylenetriaminepentaacetic acid (DTPA) are extremely harmful to the ecological environment. EDTA, DTPA, etc. have poor biodegradability, and chelating agents that do not degrade for a long time will complex heavy metals such as mercury, nickel, cadmium, and lead in soil and ore, and enter water bodies and biospheres, thereby causing a series of environmental and health problems; dangerous in the world In the Harmonized Classification and Labeling System (GHS) of chemicals, NTA is considered a carcinogen a...

Claims

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Application Information

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IPC IPC(8): C07C227/18C07C229/16C07D207/16C07D209/20C07C229/34C07C319/14C07C323/58C07D233/64D21C1/00D21C5/00D21D5/00
Inventor 苏桂珍史鲁秋公平李平许晓琴
Owner NANJING HUASHI NEW MATERIAL
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