Bone repair film and preparation method thereof

Abstract

The invention provides a bone repair film and a preparation method thereof. The bone repair film is characterized by comprising an active layer, a barrier layer and a fixed layer. The barrier layer islocated between the active layer and the fixed layer, and the active layer and the fixed layer are electrospun fiber films. The barrier layer is a cast film, the electrospun fibers in the fixed layerare aligned in fiber orientation, and the active layer contains an active ingredient. The three-layer film structure is compounded by the electrospinning technology combined with the solution castingtechnology with the aid of vacuum filtration. The bone repair film has excellent performances for simultaneously regenerating natural bone tissues and periosteal tissues. The fixed layer of the bonerepair film has the special function of fixing the whole film to avoid the use of an external fixation device and simplify the surgical procedure. At the same time, the microstructure of the fixed layer orientation is favorable for the orientation growth of the soft tissues and has the function of regenerating the natural periosteal orientation fiber layer.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bone repair membrane and a preparation method thereof. Background technique [0002] The periosteum is composed of microvascularized connective tissue that covers cortical bone surfaces except joints, and its thickness is age- and species-dependent (eg, ~40 μm in mouse tibia, ~100 μm in human tibia, ~200 μm in porcine mandible) . Traditionally, the periosteum is often divided into a superficial fibrous layer and a deep cambium, and there is no clear boundary between the two layers. The fibrous layer is thicker and consists of fibroblasts, a vascular network, and oriented (along the direction of bone growth) collagen fibers, and the thinner cambium is directly attached to the surface of the cortical bone and contains a variety of osteoid cells. Because of its association with blood vessels, the periosteum can be considered the "umbilical cord" of the bone (maint...

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Problems solved by technology

However, due to the insufficient mechanical properties of the pure electrospun membrane, it can only be applied to the regeneration of soft tissue in non-load-bearing parts and the treatment of some small-sized bone defects.

In addition, the repair membranes described in the above two patents do not have the ability to regenerate the natural periosteum with a unique structure, and both require external fixation devices (such as fixation nails) for fixation, which greatly damages the overall performance of the membrane.

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