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Poria cocos effervescent tablet and preparation method thereof

A technology of effervescent tablets and poria cocos, applied in biochemical equipment and methods, methods based on microorganisms, pharmaceutical formulas, etc., can solve the problems of many operation steps, consumption, large ethanol, etc., reduce side reactions, good hydrolysis effect, The effect of mild reaction

Inactive Publication Date: 2019-06-14
HUNAN BUTIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two processes require secondary alkalization and ethanol reaction system, and there are many operation steps and consume a large amount of ethanol

Method used

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  • Poria cocos effervescent tablet and preparation method thereof
  • Poria cocos effervescent tablet and preparation method thereof
  • Poria cocos effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Described carboxymethyl pachyrhin is prepared by following method:

[0028] S1. Cultivation of Poria cocos: aseptically inoculate Poria cocos hyphae in wort juice liquid medium, and cultivate at 28°C for 4 days;

[0029] S2. Preparation of Poria cocos polysaccharide: Ferment the cultured Poria cocos medium at 35°C for 2 days, heat to a slight boil, extract for 1 hour, filter, add 3 times the amount of mixed solvent of chloroform and n-butanol, the chloroform and n-butanol The mixed volume ratio is 4:1, shaken, centrifuged, add 3 times the amount of 95% ethanol, overnight, filter to obtain a precipitate, wash 2 times with ether to obtain pachyman;

[0030] S3. Preparation of Poria Cocos Polysaccharide: Add 10g of Poria cocos polysaccharide into 100mL0.5mol / L sodium periodate solution for selective oxidation, adjust the pH value to 3 with trifluoroacetic acid, moderate acid hydrolysis, acid hydrolysis time is 30min, filter , washing the solid with water to obtain Poria c...

Embodiment 2

[0034] Described carboxymethyl pachyrhin is prepared by following method:

[0035] S1. Cultivation of Poria cocos: aseptically inoculate Poria cocos hyphae in wort liquid culture medium, and cultivate at 28° C. for 5 days;

[0036] S2. Preparation of Poria cocos polysaccharide: Ferment the cultured Poria cocos medium at 35°C for 2 days, heat to a slight boil, extract for 2 hours, filter, add 5 times the volume of a mixed solvent of chloroform and n-butanol, the chloroform and n-butanol The mixed volume ratio is 6:1, shaken, centrifuged, add 3 times the amount of 95% ethanol, overnight, filter to obtain a precipitate, wash 3 times with ether to obtain pachymane;

[0037] S3. Preparation of Poria Cocos Polysaccharide: Add 10g of Poria cocos polysaccharide into 30mL 1.5mol / L sodium periodate solution for selective oxidation, adjust the pH value to 4 with trifluoroacetic acid, moderate acid hydrolysis, acid hydrolysis time is 1h, filter , washing the solid with water to obtain Po...

Embodiment 3

[0041] Described carboxymethyl pachyrhin is prepared by following method:

[0042] S1. Cultivation of Poria cocos: aseptically inoculate Poria cocos hyphae in wort juice liquid medium, and cultivate at 28°C for 4 days;

[0043] S2. Preparation of Poria cocos polysaccharide: Ferment the cultured Poria cocos medium at 35°C for 2 days, heat to a slight boil, extract for 2 hours, filter, add a mixed solvent of chloroform and n-butanol, the mixing volume ratio of chloroform and n-butanol 5:1, shake, centrifuge, add 3 times the amount of 95% ethanol, overnight, filter to get precipitate, wash 3 times with diethyl ether to obtain pachyrhin;

[0044] S3. Preparation of Poria Cocos Polysaccharide: Add 10g of Poria cocos polysaccharide into 50mL 1.0mol / L sodium periodate solution for selective oxidation, adjust the pH value to 3.6 with trifluoroacetic acid, moderate acid hydrolysis, acid hydrolysis time is 45min, filter , washing the solid with water to obtain Poria cocos polysaccharid...

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Abstract

The invention provides a poria cocos effervescent tablet prepared from the following raw materials: carboxymethyl pachyman, inulin, vitamin C, edible acid, edible base, diluent, lubricant, sweetener,essence and fruit powder. The edible acid is a mixture of anhydrous citric acid and tartaric acid; the edible base is sodium bicarbonate, the diluent is selected from a mixture of anhydrous lactose and sucrose, the sweetener is a mixture of acesulfame and aspartame, the lubricant is a mixture of polyethylene glycol 6000 and magnesium stearate. The preparation method is simple, dry granulation is adopted, no binder is added in a formula which is simple, and the raw materials are wide in source and low in cost. The obtained effervescent tablet has good taste and uniform bubbles and is not easy to agglomerate. The effervescent tablet has the effects of regulating blood sugar, protecting the liver, improving immunity, protecting the intestinal health and improving the immunity. The tablet is healthy food and has broad application prospects.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine health care, in particular to a Poria effervescent tablet. Background technique [0002] Poria, also known as Yuling, Fuling, Wanlinggui, and Futu, is one of the "four monarchs and eight treasures" of traditional Chinese medicine. It is the dry sclerotia of Poria cocos, a fungus of the family Phytoporaceae. It often parasitizes on the roots of pine trees and is shaped like a sweet potato. , spherical, light brown or dark brown outer skin, pink or white inner, with the effect of diuresis and dampness, invigorating the spleen and calming the heart. Medical research has further proved that Poria cocos has multiple functions such as anti-tumor, diuresis and swelling, enhancing immunity, calming the nerves and inhibiting bacteria. Poria cocos contains a variety of chemical components, the most important of which is polysaccharide, and its content can reach 84% of the dry weight of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/733A61K9/20A61P3/10A61P1/16A61P37/04A61P1/00C08B37/02C12N1/14C12P19/04C12R1/645
Inventor 孙梦锦戴鑫汶龙孝金邹奇张豪唐心文王帆
Owner HUNAN BUTIAN PHARMA
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