Self-healing injectable hydrogel, preparation method and application thereof
A hydrogel, self-healing technology, used in applications, surgical adhesives, medical science, etc., can solve problems such as body fluid leakage, adhesive damage, wound infection, etc., to prevent leakage, low cost, and method. simple effect
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Embodiment 1
[0037] (1) Preparation of aldylated chondroitin sulfate:
[0038] Weighing 5.00g chondroitin sulfate A sodium salt is dissolved in 80ml deionized water to obtain chondroitin sulfate solution; weigh 1.28g sodium periodate (NaIO 4 ) was dissolved in 20ml of deionized water to obtain a sodium periodate solution; the sodium periodate solution was slowly added dropwise to the chondroitin sulfate solution under the condition of avoiding light, the reaction temperature was 20°C, and the reaction time was 6h; after the reaction , add 3g of borax, dialyze with the dialysis bag of Mw=3500 for 2 days, change the water every 6h; then pour the product into a flat glass dish, freeze and freeze-dry at -80°C to obtain the chondroitin sulfate of aldehydization ( OCS);
[0039] (2) Preparation of aldylated chondroitin sulfate-gelatin hydrogel:
[0040] Prepare 15% w / v formylated chondroitin sulfate solution (100 mL of formylated chondroitin sulfate solution contains 15 g of formylated chondro...
Embodiment 2
[0052] (1) The preparation of formylated chondroitin sulfate is the same as step (1) in Example 1
[0053] (2) Preparation of aldylated chondroitin sulfate-gelatin hydrogel:
[0054] Use PBS buffer to prepare 15% w / v formylated chondroitin sulfate and 22.5% w / v gelatin solution (gelatin solution is prepared by dissolving at 50°C); mix the two solutions in equal volumes to generate a Schiff base Reaction, the mixing reaction temperature is 37°C, and the mixing time is 20s to obtain the Gel-OCS hydrogel pre-polymerization liquid;
[0055] (3) Formylated chondroitin sulfate-gelatin hydrogel / Fe 3+ The preparation of the hydrogel was the same as (3) in Example 1.
[0056] Gel-OCS / Fe in this embodiment 3+ The rheology and adhesion tests of the hydrogel were the same as in Example 1.
[0057] Gel-OCS / Fe 3+ The storage modulus of the hydrogel is 986Pa, and the adhesion force is 3.03N / cm 2 (Pigskin test adhesion).
Embodiment 3
[0059] (1) the preparation of aldylated chondroitin sulfate is the same as step (1) in Example 1;
[0060] (2) Preparation of aldylated chondroitin sulfate-gelatin hydrogel:
[0061] Use PBS buffer to prepare 10% w / v aldylated chondroitin sulfate solution and 20% w / v gelatin solution, and dissolve the gelatin solution at 50°C; mix the two solutions in equal volumes to generate a Schiff base Reaction, the mixing reaction temperature is 37°C, and the mixing time is 20s to obtain the Gel-OCS hydrogel pre-polymerization liquid;
[0062] (3) Formylated chondroitin sulfate-gelatin hydrogel / Fe 3+ The preparation of the hydrogel was the same as (3) in Example 1.
[0063] Gel-OCS / Fe in this embodiment 3+ The rheology and adhesion test of hydrogel are identical with embodiment 1
[0064] Gel-OCS / Fe 3+ The storage modulus of the hydrogel is 679Pa, and the adhesion force is 2.43N / cm 2 .
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