Method for preparing hollow microneedles by ultraviolet curing process with soluble fiber as core material

Abstract

The invention discloses a method for preparing a hollow microneedle through an ultraviolet-curing process using a soluble fiber as a core material. The method can be carried out at the room temperature, and the preparation time is short, which is advantageous for preparing a hollow microneedle array quickly and batchwise. Compared with an existing hollow microneedle preparation method, an ultraviolet-curing molding method is adopted to avoid a heating and melting process of a polymer material, a high temperature condition is not required, and requirements for a preparation environment are low;the ultraviolet-curing process has a short molding time, and the microneedle can be formed by 2-3 minute exposure of a photoresist in an ultraviolet light, which greatly shortens the preparation cycle; the hollow part of the microneedle adopts a molding method of using the soluble PVA fiber as the core material, due to the characteristic that the soluble PVA fiber can be dissolved in the water, so that the molding process of the hollow part becomes simple and fast, and the molding difficulty of the hollow microneedle is reduced.

Description

technical field [0001] The invention relates to a method for preparing hollow microneedles by using soluble fiber as a core material through an ultraviolet curing process, and belongs to the technical field of medical devices. Background technique [0002] In medicine, for some diseases, traditional oral administration and injection are usually used for treatment. However, the former will cause partial loss of drug effect after the drug is digested by the stomach, and even affect and destroy the function of liver organs; while the latter will cause skin tissue damage and infection. In order to avoid these disadvantages, transdermal drug delivery system has become a better treatment method. This method allows the drug to penetrate the skin at a certain rate, absorb into the blood circulation through capillaries, and achieve an effective blood drug concentration to produce curative effect. However, there are about 95% keratinocytes in the epidermis of the skin, which have a ...

AI Technical Summary

Problems solved by technology

In addition, the preparation method of hollow microneedles usually uses multi-step ion etching and laser etching to form the hollow part of the microneedle, and the operation steps are relatively cumbersome.

The disadvantage of these methods is that they require complex preparation processes, and the preparation cycle is long, and the preparation cost is also high, which greatly limits the scope of use of hollow microneedle arrays.

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