Composite polylactic acid biomaterial and preparation method thereof

A biomaterial, polylactic acid technology, applied in the field of orthopaedic materials, can solve the problems of mechanical properties and service life that cannot meet the needs of patients, and achieve the effects of excellent biocompatibility, improved biocompatibility, and controllable time.

Active Publication Date: 2019-04-19
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a composite polylactic acid orthopedic material and its preparation method to solve the problem that the existing polylactic acid orthopedic materials cannot meet the needs of patients in terms of mechanical properties and service life

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The composite polylactic acid biological material of the present embodiment is made of the following raw materials in parts by weight: 12 parts of chitosan complex, 6 parts of silk fibroin, 15 parts of hydroxyapatite, 3.5 parts of polyethylene glycol 600, lactide 60 parts and 0.65 parts of silane coupling agent. Prepare as follows:

[0029] Preparation of carboxylated multi-walled carbon nanotubes: Weigh 0.3g of polyethylene glycol and 9.5% of pearl powder into 500mL deionized water, ultrasonically disperse, and freeze-dry at -20~-10°C to obtain modified pearl powder, take more than 2g Wall carbon nanotubes were added to 500mL of deionized water, then 2g of modified pearl powder was added for ultrasonic dispersion, and the solid product obtained by filtration was added to a mixed acid prepared by concentrated sulfuric acid and concentrated nitric acid with a volume ratio of 3:1, and the ultrasonic reaction was carried out at 500W for 3h , vacuum filtration, and washing...

Embodiment 2

[0035] The composite polylactic acid biological material of the present embodiment is made of the following raw materials in parts by weight: 10 parts of chitosan complex, 5 parts of silk fibroin, 16 parts of hydroxyapatite, 0.2 part of diethylene glycol dimethyl ether, propylene glycol dimethyl ether, 65 parts of lactide and 0.8 parts of silane coupling agent. Prepare as follows:

[0036] The preparations of carboxylated multi-walled carbon nanotubes, aminated hyaluronic acid, hyaluronic acid / carbon nanotubes and chitosan composites in this example are exactly the same as in Example 1.

[0037] Dissolve silk fibroin powder in deionized water to prepare a 10 mg / mL silk fibroin solution, weigh calcium chloride and potassium dihydrogen phosphate according to the stoichiometric ratio and add them to a citric acid solution with a mass fraction of 2%, and stir Uniformly, obtain the hydroxyapatite precursor solution; mix the silk fibroin protein solution and the hydroxyapatite prec...

Embodiment 3

[0039] The composite polylactic acid biological material of the present embodiment is made of the following raw materials in parts by weight: 15 parts of chitosan complex, 8 parts of silk fibroin, 10 parts of hydroxyapatite, and diethylene glycol with a mass ratio of 1:1. 5 parts of a mixture of dimethyl ether and xylitol 600, 50 parts of lactide and 0.5 parts of a silane coupling agent. Prepare as follows:

[0040] The preparations of carboxylated multi-walled carbon nanotubes, aminated hyaluronic acid, hyaluronic acid / carbon nanotubes and chitosan composites in this example are exactly the same as in Example 1.

[0041] Dissolve silk fibroin powder in deionized water to prepare a 10 mg / mL silk fibroin solution, weigh calcium chloride and potassium dihydrogen phosphate according to the stoichiometric ratio and add them to a citric acid solution with a mass fraction of 2%, and stir Uniformly, obtain the hydroxyapatite precursor solution; mix the silk fibroin protein solution ...

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PUM

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Abstract

The invention relates to the technical field of orthopedic materials, and concretely relates to a composite polylactic acid biomaterial and a preparation method thereof. The composite polylactic acidbiomaterial comprises by weight, 10-15 parts of a chitosan compound, 5-8 parts of silk fibroin, 10-16 parts of hydroxyapatite, 0.2-5 parts of a compatibilizer, 50-65 parts of lactide and 0.5-0.8 partof a silane coupling agent, wherein chitosan compound is prepared by an electrospray process of chitosan and hyaluronic acid / carbon nanotube, and the hyaluronic acid / carbon nanotube is mainly preparedthrough a reaction of aminated hyaluronic acid and a carboxylated multiwalled carbon nanotube and dialysis. The composite polylactic acid biomaterial prepared in the invention has a good biocompatibility, meets the requirements of the mechanical performance of bones, has a service life fully meeting the needs of patients, and solves a problem that the service life of existing orthopedic materialscannot fully meet the needs of patients.

Description

technical field [0001] The invention relates to the technical field of orthopedic materials, in particular to a composite polylactic acid biological material and a preparation method thereof. Background technique [0002] Orthopedic implant materials mainly include joint replacement, bone plate and dental implant materials. An ideal orthopedic implant material should have excellent biocompatibility, and at the same time require sufficient load capacity, wear and corrosion resistance, and long service life. However, it is difficult for common orthopedic implant materials to meet the above requirements at the same time. [0003] At present, orthopedic implant materials mainly include: metals or alloys, ceramics, and high molecular polymers. Among them, although metal materials have strong load-bearing capacity, they are usually difficult to form chemical bonds with bone tissue, and problems such as wear and corrosion cannot be avoided; ceramics have excellent biological acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L5/08C08L89/00C08K3/32C08K9/02C08K3/04
CPCC08K2003/325C08K2201/011C08L67/04C08L2205/025C08L2205/035C08L5/08C08L89/00C08K3/32C08K9/02C08K3/041
Inventor 屈一鸣
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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