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Peanut coating active components and its application in the preparation of anti-obesity and anti-diabetic drugs

An active component, anti-diabetic technology, applied in anti-diabetic drugs, the active component of peanut clothing and its application in the field of preparation of anti-obesity, can solve the problems of easy rebound and many side effects

Active Publication Date: 2021-05-25
河北凯翔健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although most of the oral hypoglycemic drugs currently used to treat obesity and diabetes have certain effects, they have the disadvantages of easy rebound after drug withdrawal and many side effects.

Method used

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  • Peanut coating active components and its application in the preparation of anti-obesity and anti-diabetic drugs
  • Peanut coating active components and its application in the preparation of anti-obesity and anti-diabetic drugs
  • Peanut coating active components and its application in the preparation of anti-obesity and anti-diabetic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 peanut shell active component extraction

[0032] Take 60% ethanol to soak the peanut coat twice, the first time for 1 hour, the second time for 0.5 hours, then filter with suction, concentrate to 1 / 50 of the original volume, and then use macroporous adsorption resin HP-20 to separate and elute The solvent is 40% ethanol, and fractions are collected, which are the active components of peanut shells.

Embodiment 2

[0033] Embodiment 2 peanut shell active component component analysis

[0034] experimental method:

[0035] The peanut shell active component is divided into two parts by high performance liquid chromatography (HPLC), the conditions are: Develosil ODS-UG-5 (φ20×250mm), Nomura Chemical column, 6ml / min flow rate, 0-15min, 18% methanol isocratic Elution, collected as sugar components; 15-25min, 18%-100% methanol gradient elution, 25-40min, 100% methanol isocratic elution, collected as non-sugar components. Afterwards, the components of the sugar and non-sugar parts were analyzed by spectral analysis, high-resolution mass spectrometry and chemical derivatization methods.

[0036] Experimental results:

[0037] Through the analysis of these two parts of hydrogen spectrum and carbon spectrum nuclear magnetic spectrum ( Figure 1-4 ), confirming that these two parts are the sugar part and the non-sugar part, respectively. Afterwards, the sugars were partially hydrolyzed and acety...

Embodiment 3

[0044] The research of the preparation method of embodiment 3 experimental type 2 diabetes mice

[0045] High-fat diet is the main way to induce obese type 2 diabetes model. In order to correctly prepare experimental type 2 diabetes mice, this example established a type 2 diabetes pathological model by feeding high-fat diet for a long time.

[0046] experimental method:

[0047] In this embodiment, the experimental animals are divided into a control group and a model group. The control group was given normal feed, and the model group was given high-fat feed (all provided by Shanghai Slack Experimental Animal Co., Ltd.). The feeding period was 5 months, and the food intake, water intake and body weight of the animals were measured every week. In the last week of modeling, the mice were fasted and their blood sugar levels were measured. When the weight increased significantly and the blood sugar level was greater than 9, the mice were judged as type 2 diabetic mice.

[0048] ...

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Abstract

The invention provides an active component of peanut shells, which is obtained by leaching peanut shells with ethanol, suction filtration, concentration, separation with macroporous adsorption resin, and fraction collection. In anti-obesity and diabetes in vivo experiments, the present invention has confirmed that the active components of peanut coat can regulate adiponectin and leptin signaling pathways to reduce body weight and blood sugar through animal models of diabetes, and can significantly reduce experimental obesity mice and 2 The food intake, body weight and blood sugar level of type 2 diabetes model mice can significantly improve the clinical symptoms of obesity and diabetes. It can be used in the preparation of food, health food and medicine for preventing and treating obesity and diabetes.

Description

technical field [0001] The invention belongs to the field of medicine and food of compounds, and relates to the active component of peanut shell and its application in the preparation of anti-obesity and anti-diabetes drugs. Background technique [0002] As a global epidemic, obesity and diabetes have become one of the biggest public health problems in the 21st century. According to the World Health Organization report in 2014, more than 1.9 billion adults are overweight, and more than 600 million people are obese. Obesity is a risk factor leading to a sharp increase in non-alcoholic fatty liver disease, type 2 diabetes, cardiovascular disease, and cancer, all of which not only seriously affect the quality of human life, but also shorten human life span. Especially type 2 diabetes, if it is not treated timely and effectively, it is very easy to have complications such as coronary heart disease, cerebrovascular disease, nephropathy, retinopathy and other complications. These ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P3/04A61P3/10A23L33/105A61K131/00
CPCA23V2002/00A61K36/48A61K2236/333A61K2236/39A61K2236/51A61K2236/55A23L33/105A61P3/04A61P3/10A23V2200/328A23V2200/332
Inventor 向兰戚建华程丽红吴巧贝
Owner 河北凯翔健康科技有限公司
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