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Application of crocin in preparing medicament for treating non-alcoholic steatohepatitis

A crocetin and non-alcoholic technology, which is applied in the field of crocetin to prepare drugs for treating non-alcoholic steatohepatitis, can solve the problems of no specific drugs for the treatment of NASH, achieve good social and economic benefits, and is convenient to take and cost-effective. The effect of abundant drug resources

Inactive Publication Date: 2019-04-16
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In general, although there are many kinds of drugs for treating liver diseases, there is no specific drug for the treatment of NASH. Therefore, it is very necessary to actively look for drugs that can resist alcoholic steatohepatitis, and it is particularly important to take advantage of the advantages of traditional Chinese medicine treatment

Method used

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  • Application of crocin in preparing medicament for treating non-alcoholic steatohepatitis
  • Application of crocin in preparing medicament for treating non-alcoholic steatohepatitis
  • Application of crocin in preparing medicament for treating non-alcoholic steatohepatitis

Examples

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Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Preparation of crocus acid

[0019] Weigh 10 g of gardenia yellow into 800 ml of water to dissolve, adjust the pH to 12 with 2M NaOH, and place at room temperature for 6 hours. Reuse 1M H 2 SO 4 The pH was adjusted to 2, placed in a refrigerator at 4°C overnight, and the filtered material was recrystallized three times with methanol and glacial acetic acid with a volume ratio of 4:1 to obtain the final product - crocetin; The purity of anthocyanic acid detected by HPLC is ≥98%, such as figure 1 .

Embodiment 2

[0047] Example 2 Pharmaceutical formulations comprising crocus acid

[0048] Weigh 1kg of Gardenia Yellow, add pure water to 80L, adjust the pH of the solution to 12 with 2M NaOH, and place it at room temperature for 6h, then use 1M H2O to adjust the pH of the solution to 12. 2 SO 4 The pH of the solution was adjusted to 2, and the solution was placed at 4°C overnight for suction filtration, and the suction-filtered material was recrystallized three times with methanol and glacial acetic acid in a volume ratio of 4:1 to obtain the final product - crocus acid. Crocus acid is red powder, insoluble in water, and can be made into tablets, capsules, sustained-release tablets, dropping pills, granules, granules or injections by adding corresponding excipients.

[0049] The recommended clinical dose of crocus acid: 100-250 mg / day, orally, 3 times a day.

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Abstract

The invention relates to application of crocin in preparing a medicament for treating non-alcoholic steatohepatitis, wherein the crocin is an effective component extracted from Chinese medicinal materials of saffron or gardenia yellow and can remarkably reduce aspartate transaminase, glutamic-pyruvic transaminase and the like in a high-fat diet steatohepatitis animal model, has protective effect on hepatocytes in a fatty liver hepatitis model, is used for oral administration for treating non-alcoholic steatohepatitis, is convenient to take, has small toxic and side effects, and has no harm after long-term administration.

Description

technical field [0001] The invention relates to a new use of crocus acid, in particular to the use of crocus acid in the field of pharmacy, in particular to the use of crocus acid in preparing a medicine for treating nonalcoholic steatohepatitis. Background technique [0002] Crocetin is also known as crocus and saffron. Crocetin is one of the main active chemical components in the upper part and stigma of crocus of Iridaceae. Saffron was first artificially cultivated by the Greeks. It is a precious Chinese medicinal material. It was introduced to China in the Ming Dynasty. According to literature reports, saffron has strong physiological activity, has sedative, expectorant, and antispasmodic effects. It is used for the treatment of stomach diseases, menstruation, measles, fever, jaundice, hepatosplenomegaly, etc., but no saffron has been seen yet. A report on the preventive effect of anthocyanic acid on nonalcoholic steatohepatitis. [0003] In recent years, due to factor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/557A61P1/16C07C51/43C07C57/13
CPCA61K31/557A61P1/16C07C51/43C07C57/13
Inventor 王平林素素江瑜
Owner ZHEJIANG UNIV OF TECH
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