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New application of Heterosmilacis Rhizoma to preparation of medicine for treating hepatic fibrosis

A technology for liver fibrosis and Tutai tablets, applied in the field of Tutai tablets, can solve the problem of not finding soil tablets, etc., and achieve the effects of reducing the infiltration of inflammatory cells in liver tissue, high safety, and improving the degree of liver fibrosis.

Inactive Publication Date: 2016-04-13
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no literature reports on the use of Tutai Tablets, Tutai Tablet alcohol extracts, and Tutai Tablet total saponins in the treatment of liver fibrosis

Method used

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  • New application of Heterosmilacis Rhizoma to preparation of medicine for treating hepatic fibrosis
  • New application of Heterosmilacis Rhizoma to preparation of medicine for treating hepatic fibrosis
  • New application of Heterosmilacis Rhizoma to preparation of medicine for treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: Preparation of Tutai Tablet Alcohol Extract

[0039] Take 1 kg of Tutai Tablets and pulverize them, add 95% ethanol to reflux for 2 extractions according to 8 times the weight of the medicinal materials, each extraction time is 1 hour, filter, combine the extracts, filter, concentrate, dry, and obtain Tutai Tablets for alcohol extraction things.

[0040] The extraction yield of Tutai Tablet alcohol extract is 11.5%.

Embodiment 2

[0041] Embodiment 2: Preparation of Tutai Tablet Alcohol Extract

[0042] Take 1kg of Tutai Tablets and pulverize them, add 70% ethanol to reflux and extract 3 times according to 12 times the weight of the medicinal materials, each extraction time is 2h, filter, combine the extracts, filter, concentrate, dry, and obtain Tutai Tablets for alcohol extraction things.

[0043] The yield of the alcohol extract of Tutai Tablet was 13.2%.

Embodiment 3

[0044] Embodiment 3: the preparation of total saponins of Tutai tablet

[0045] Take 1 kg of Tutai slices, grind them, add 80% ethanol to reflux and extract 3 times, the amount of ethanol each time is 8 times, 10 times, and 12 times the total weight of the medicinal materials, and the extraction time is 1 hour each time, filter, and combine the extracts , concentrated under reduced pressure to 1.5 times the weight of the medicinal material, cooled to room temperature, centrifuged at 3000r / min for 15min, and separated the supernatant. D101 macroporous resin on the supernatant, eluted with 3BV of water, 4BV of 20% ethanol in turn, discarded the eluent, and then eluted with 4BV of 60%, 3BV of 80% ethanol, collected and combined the eluate, concentrated, dried, and obtained soil Total Saponin Extract of Tai Pian.

[0046] Taking diosgenin as the control, the absorbance was measured by vanillin-perchloric acid-glacial acetic acid colorimetric method, and calculated according to th...

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Abstract

The invention relates to new application of Heterosmilacis Rhizoma, namely new application of the Heterosmilacis Rhizoma to preparation of medicine for treating hepatic fibrosis, in particular to new application of Heterosmilacis Rhizoma extract and Heterosmilacis Rhizoma total saponins to preparation of the medicine for treating hepatic fibrosis.

Description

technical field [0001] The invention relates to a new application of Tutai Tablet, in particular to a new application of Tutai Tablet extract and total saponins of Tutai Tablet, that is, a new application in preparing medicine for treating liver fibrosis. Background technique [0002] Hepatic fibrosis is a compensatory response in the tissue repair process secondary to various forms of chronic liver injury. It is a pathological process caused by the imbalance of extracellular matrix synthesis, degradation and deposition when the tissue repair response occurs. Cells in the liver- Cells, cell-matrix, and matrix-transmitter interactions form a complex network system that participates in the occurrence and development of liver fibrosis. Liver fibrosis is an important pathological feature of chronic liver disease, and it is also the main intermediate link in the further development of liver cirrhosis. If the cause persists, the liver fibrosis will gradually increase, the normal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P1/16
CPCA61K36/896A61K36/90A61K2236/333A61K2236/39A61K2236/53A61K2236/55
Inventor 吴赛春刘冠萍陈红许巍严灿梅
Owner GUANGXI WUZHOU PHARMA GRP
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