Anticoagulant composite hollow fiber membrane and preparation method thereof

Abstract

The invention belongs to the field of biological materials, and particularly relates to an anticoagulant composite hollow fiber membrane and a preparation method thereof. The fiber membrane comprisespolyethersulfone, maleylated chitosan and a water-soluble polymer pore-forming agent, wherein the polyethersulfone is in a porous grid framework structure, and after being modified by the maleylated chitosan, the biocompatibility of the polyethersulfone is increased, the platelet aggregation is reduced, and the anticoagulant performance is improved; by adding the water-soluble polymer pore-formingagent, on one hand, the inner diameter, pore diameter and porosity of the fiber membrane can be adjusted, so that the permeability of the fiber membrane is controlled; on the other hand, the water-soluble polymer pore-forming agent is embedded in the porous grid framework structure and is matched with the maleylated chitosan, so that the stability is good, the water-soluble polymer pore-forming agent is not easy to elute and can be used for a long time. The fiber membrane is used as a dialysis membrane to carry out hemodialysis on a patient without using heparin, so that the diseases such asosteoporosis, low coagulation performance and the like of the patient are avoided. The preparation method is simple and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to an anticoagulant composite hollow fiber membrane and a preparation method thereof. Background technique [0002] Hemodialysis is one of the renal replacement therapy methods for patients with acute and chronic renal failure. The dialysis process is to drain the blood containing metabolic waste from the patient's body to the outside of the body, and filter out the metabolic waste through the dialysis membrane in the hemodialyzer. Injected into the patient's body to achieve the purpose of blood purification. Among them, the dialysis membrane is composed of countless hollow fibers. When the blood flows through the hollow fibers, the electrolyte solution (dialysate) with a similar concentration outside the hollow fibers performs material exchange through diffusion, ultrafiltration, adsorption, and convection to remove the blood from the blood. Toxins and excessive wat...

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Problems solved by technology

However, the current advanced sterilization method for hemodialyzers is steam sterilization, and the pore structure of polysulfone membrane material will change at 80°C for a long time, so it is not suitable for 138°C steam sterilization process

The Tg of polyethersulfone is as high as 223°C, and it can be used for a long time at 140°C. It can be used as the material of choice for steam sterilization. However, polyethersulfone shows a certain degree of hydrophobicity (water contact angle is about 75°). When it is used in hemodialysis, the surface of the hydrophobic membrane material is easy to adsorb plasma protein, coagulation factors or platelets, etc. and activate the coagulation system. It is easy to cause protein contamination after long-term use, and then the phenomenon of "blocking holes" occurs, thereby reducing the use of blood pressure dialyzers. efficiency

Studies have found that the modification of polyethersulfone can improve the anti-fouling and anti-coagulation properties of polyethersulfone membranes, such as PVP modification, MPC modification, etc., but there are many problems in such modified polyethersulfone materials. For example, the PVP-modified polyethersulfone has the problem of easy elution of PVP, which leads to the unsustainable anti-coagulation performance of the membrane material; the preparation cost of MPC is high, and the improvement of anti-coagulation performance is limited

Therefore, it is necessary to use coagulation substances (such as heparin) to patients after applying this type of membrane material to hemodialysis, and long-term use of heparin will not only increase the economic burden, but also cause diseases such as osteoporosis and low coagulation performance.

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