Production method for targeting onychomycosis resistant skin gel dressing

Abstract

The invention discloses a production method for a targeting onychomycosis resistant skin gel dressing. The production method is characterized by comprising the following steps of 1) preparation of plant essential oil; 2) preparation of thermosensitive sustained release carboxylated chitosan-curdlan polysaccharide composite gel; and 3) preparation of an antifungal skin gel dressing, wherein variouscomponents are proportioned according to the mass ratio as follows: 30-50wt% of the composite gel, 10-20wt% of water, 1-5wt% of glycerinum, 1-5wt% of ethyl alcohol, 20-35wt% of the plant essential oil, 1-5wt% of polysorbate 80 type and 1-3wt% of triethanolamine. The targeting onychomycosis resistant skin gel dressing does not have the corrosivity by taking the plant essential oil as a Chinese patent medicine as a main component for treatment of onychomycosis, is strong in sensibility to pathogenic bacteria and good in permeability, is obvious in curative effect as various fungicidal compoundshave the synergistic interaction and has good glutinousness and hydrophilic gel property so as to have better drug component controlled release effect, the drug components can diffuse outward at a uniform speed through a transmission channel to ensure the administration persistence, and the targeting onychomycosis resistant skin gel application can meet the requirement on long-time durable administration of onychomycosis pathomycete.

Description

technical field [0001] The present invention relates to the production technology of external medicine for treating onychomycosis, especially relates to extracting the essential oil extracts of Artemisia indica, Perilla leaf, Artemisia annua, Trichofern, Litsea Cubeba, Chuanjiao, Citron and Clove, and extracting them with carboxylate The invention relates to a production process of preparing a composite matrix of chitosan and candlan polysaccharide as an auxiliary material to make a temperature-sensitive gel dressing, which belongs to the technical field of antifungal external drug production. Background technique [0002] Onychomycosis (being commonly called as tinea unguium, onychomycosis) is the deck and subungual tissue infection that is caused by dermatophytosis tinea, yeast and mold. According to literature reports, the main bacterial species causing onychomycosis are: dermatophytes (mainly Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton flocculus, etc.)...

AI Technical Summary

Problems solved by technology

According to incomplete statistics, more than 300 kinds of Chinese herbal medicines have been reported to have different degrees of antifungal effects, but the anti-onychomycosis drugs developed by natural products are slow in efficacy, mainly because these drugs are mostly directly compounded from several kinds of Chinese herbal medicine raw materials It is made without extracting and concentrating active ingredients, so that the concentration is not high, and the effect on the inhibition and killing of germs is limited

In addition, common traditional external application drugs are highly volatile, and the active ingredients will volatilize within half an hour, which greatly reduces the bactericidal effect. Therefore, further research and development is required to extend the duration of drug effects