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Astaxanthin nanometer preparation prepared by electrostatic spraying method and preparation method thereof

A nano-preparation and electrostatic spraying technology, which is applied in the direction of anti-inflammatory agents, anti-toxic agents, pill delivery, etc., can solve the problems of preparation technology blank, achieve good solubility, increase release speed, and improve oral bioavailability

Active Publication Date: 2019-03-08
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disclosed astaxanthin microencapsulated preparation is mainly a liquid system, and its main preparation technology is the in-liquid encapsulation method, and the astaxanthin micro-nano powder preparation with high solubility, fast release and high bioavailability and its Preparation technology is still blank

Method used

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  • Astaxanthin nanometer preparation prepared by electrostatic spraying method and preparation method thereof
  • Astaxanthin nanometer preparation prepared by electrostatic spraying method and preparation method thereof
  • Astaxanthin nanometer preparation prepared by electrostatic spraying method and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1 astaxanthin nano preparation

[0035] (1) Accurately weigh 10 mg of astaxanthin and 20 mg of phospholipid, place them in 10 mL of dichloromethane / methanol solvent (volume ratio 2:8), wherein the total concentration of absorption-promoting components in the nuclear layer solution is 0.2%, and ultrasonically disperse for 1-2 After 20 minutes, stir magnetically for 20 minutes to mix evenly to a transparent and clear solution to obtain a core layer solution; dissolve 40 mg of PEG-g-CS and 20 mg of PEO in 10 mL of distilled water so that the total concentration of the shell layer carrier is 0.6%, and disperse ultrasonically for 1-2 minutes After that, magnetically stir for 20 minutes to mix evenly until a transparent and clear solution is obtained to obtain a shell solution.

[0036] (2) Put 10mL each of the core layer solution and the shell layer solution into the syringe, and slowly output it from the constant flow pump. The spray speed of the core layer solut...

Embodiment 2

[0037] Embodiment 2 astaxanthin nano-preparation

[0038] (1) Accurately weigh 10 mg of astaxanthin, 40 mg of phospholipid, 40 mg of PVP K30, and 40 mg of PEG 6000, and place them in 10 mL of dichloromethane / methanol solvent (volume ratio 3:7), in which the hydrophilic polymer carrier and The total concentration of absorption-promoting ingredients is 1.2%. After ultrasonic dispersion for 1-2 minutes, stir magnetically for 20 minutes and mix evenly until a transparent and clear solution is obtained to obtain a nuclear layer solution; PEG-g-CS 200mg and PEO 60mg are dissolved in 10mL distilled water to The total concentration of the shell layer carrier is 2.6%. After ultrasonic dispersion for 1-2 minutes, the mixture is mixed uniformly by magnetic stirring for 20 minutes until a transparent and clear solution is obtained to obtain a shell layer solution.

[0039] (2) Put 10 mL each of the core layer solution and the shell layer solution into the syringes, and slowly output it fr...

Embodiment 3

[0040] Embodiment 3 astaxanthin nano-preparation

[0041] (1) Accurately weigh 10 mg of astaxanthin, 30 mg of phospholipid, 20 mg of PVP K30, and 20 mg of PEG 4000, and place them in 10 mL of dichloromethane / methanol solvent (volume ratio 4:6), in which the hydrophilic polymer carrier and The total concentration of the absorption-promoting ingredients is 0.7%. After ultrasonic dispersion for 1-2 minutes, stir magnetically for 20 minutes and mix evenly to a transparent and clear solution to obtain a nuclear layer solution; dissolve 150 mg of PEG-g-CS and 60 mg of PEO in 10 mL of distilled water to make The total concentration of the shell carrier is 2.1%. After ultrasonic dispersion for 1-2 minutes, the mixture is mixed uniformly by magnetic stirring for 20 minutes until a transparent and clear solution is obtained to obtain a shell solution.

[0042] (2) Put 10mL each of the core layer solution and the shell layer solution into the syringe, and slowly output it from the consta...

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Abstract

The invention discloses an astaxanthin nanometer preparation prepared by an electrostatic spraying method and a preparation method thereof, and relates to the field of nanometer drug preparations. Theastaxanthin nanometer preparation consists of astaxanthin, a nuclear layer carrier and a shell layer carrier; a drug, a hydrophilic polymer carrier and an absorption promoting component are dissolvedin a nuclear layer mixed solvent; the hydrophilic polymer carrier is dissolved in water, and the astaxanthin solid nanometer preparation is prepared by the hydrophilic polymer carrier and the absorption promoting component by adopting the coaxial electrostatic spraying method. The mass ratio of the astaxanthin to the hydrophilic polymer carrier to the absorption promoting component in a nuclear layer solution is 1 to 0-8 to 2-4; the total concentration of the hydrophilic polymer carrier and the absorption promoting component in the nuclear layer solution is 0.2-1.2 percent (w / v); the total concentration of the shell layer carrier is 0.6-2.6 percent (w / v). The volume ratio of the nuclear layer solution to a shell layer solution is 1 to 1 (v / v). The astaxanthin nanometer preparation and thepreparation method thereof disclosed by the invention have the benefits that the solubility of the astaxanthin is significantly increased, the in-vitro drug release rate of the astaxanthin is improved, and the oral bioavailability is improved; the astaxanthin nanometer preparation is simple in process and high in degree of industrialization; the prepared astaxanthin solid nanometer preparation isuniform in particle size and stable in character, thereby having a better application prospect.

Description

technical field [0001] The invention relates to the field of nano-pharmaceutical preparations, in particular to astaxanthin nano-preparations of an insoluble active ingredient and a preparation method thereof. Background technique [0002] Astaxanthin, 3,3'-dihydroxy-4,4'-diketo-β,β'-carotene, is a ketone-type non-vitamin A source carotenoid, which is a reddish-brown terpene ethylenically unsaturated compounds. As a chain-breaking antioxidant, astaxanthin can not only quench singlet oxygen, directly scavenge oxygen free radicals, but also block the chain reaction of fatty acids, and has strong antioxidant activity (see: Zuluaga, M. , V. Gueguen, D. Letourneur, et al., Astaxanthin-antioxidant impact on excessive Reactive Oxygen Species generation induced byischemia and reperfusion injury [J]. Chemico-Biological Interactions, 2018.279:145-158). Therefore, astaxanthin, also known as "super antioxidant", is considered to be the natural substance with the strongest antioxidant ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/51A61K31/122A61K47/32A61K47/10A61K47/36A61P3/10A61P9/10A61P9/12A61P29/00A61P35/00A61P39/06
CPCA61K9/2081A61K9/2095A61K9/5138A61K9/5146A61K9/5161A61K9/5192A61K31/122A61P3/10A61P9/10A61P9/12A61P29/00A61P35/00A61P39/06
Inventor 朱源许雯廖有武余剑吟徐希明
Owner JIANGSU UNIV
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