Preparation method of barbary wolfberry fruit, florists chrysanthemum flower and adhesive rehmannia root pill by freeze-grinding technique
A Qiju Dihuang pill, freezing and crushing technology, applied in the medical field, can solve problems such as unstable content determination, easy sticking to the pulverizer, and difficulty in fully kneading, so as to improve bioavailability, improve curative effect, and shorten drug onset time Effect
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Embodiment 1
[0013] The present invention is calculated by weight percentage: wolfberry 9%, chrysanthemum 9%, rehmannia glutinosa 29%, wine cornel 15%, moutan bark 12%, yam 10%, poria cocos 8% and Alisma 8%, the total amount is 100% Made as bulk drug, the preparation steps are as follows:
[0014] (1) Take wolfberry fruit, wine cornus and rehmannia glutinosa three flavor raw materials and put them into the liquid nitrogen freezing and grinding room, freeze at -30°C for 15 minutes, put them into the freezing grinder, and grind them at the low temperature of -70°C into a very fine powder through a 75µm aperture sieve;
[0015] (2) Take chrysanthemum, Moutan cortex, Chinese yam, Poria cocos and Alisma, put them in a pulverizer at room temperature and pulverize them into a very fine mixed powder passing through a sieve with an aperture of 75 μm;
[0016] (3) Put the ultra-fine powder and the ultra-fine mixed powder into the cylinder mixer and mix for 30 minutes, put it in a circulating steam ...
Embodiment 2
[0019] The present invention is calculated by weight percentage: 5% medlar, 5% chrysanthemum, 30% Rehmannia glutinosa, 15% wine cornus, 8% moutan cortex, 13% Chinese yam, 12% Poria cocos and 12% Alisma alisma, the total amount is 100% Made as bulk drug, the preparation steps are as follows:
[0020] (1) Take wolfberry fruit, wine cornel and rehmannia glutinosa three raw materials and put them into the liquid nitrogen freezing and grinding room, freeze at -32°C for 15 minutes, put them into the freezing grinder, and grind them at the low temperature of -75°C into a very fine powder through a 75µm aperture sieve;
[0021] (2) Take chrysanthemum, Moutan cortex, Chinese yam, Poria cocos and Alisma, put them in a pulverizer at room temperature and pulverize them into a very fine mixed powder passing through a sieve with an aperture of 75 μm;
[0022] (3) Put the ultra-fine powder and the ultra-fine mixed powder into the cylinder mixer and mix for 30 minutes, put it in a circulatin...
Embodiment 3
[0025] The present invention is calculated by weight percentage: wolfberry 8%, chrysanthemum 7%, rehmannia glutinosa 25%, wine cornus 10%, moutan cortex 11%, yam 15%, poria cocos 12% and Alisma 12%, the total amount is 100% Made as bulk drug, the preparation steps are as follows:
[0026] (1) Take wolfberry fruit, wine cornus and rehmannia glutinosa three raw materials and put them into the liquid nitrogen freezing and grinding room, freeze at -35°C for 15 minutes, put them into the freezing grinder, and grind them at -80°C into a very fine powder through a 75µm aperture sieve;
[0027] (2) Take chrysanthemum, Moutan cortex, Chinese yam, Poria cocos and Alisma, put them in a pulverizer at room temperature and pulverize them into a very fine mixed powder passing through a sieve with an aperture of 75 μm;
[0028] (3) Put the ultra-fine powder and the ultra-fine mixed powder into the cylinder mixer and mix for 30 minutes, put it in a circulating steam sterilizer, sterilize it a...
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