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Preparation method of barbary wolfberry fruit, florists chrysanthemum flower and adhesive rehmannia root pill by freeze-grinding technique

A Qiju Dihuang pill, freezing and crushing technology, applied in the medical field, can solve problems such as unstable content determination, easy sticking to the pulverizer, and difficulty in fully kneading, so as to improve bioavailability, improve curative effect, and shorten drug onset time Effect

Inactive Publication Date: 2019-03-01
河南百年康鑫药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a preparation method for producing Qiju Dihuang Pills by using the freeze crushing technology, which can effectively solve the problem that some medicinal materials contain too much sugar, and it is difficult to fully knead together with other medicinal materials. When it is easy to stick to the pulverizer, it will affect the follow-up process, the treatment effect is poor, and the content determination is unstable.

Method used

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  • Preparation method of barbary wolfberry fruit, florists chrysanthemum flower and adhesive rehmannia root pill by freeze-grinding technique

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Effect test

Embodiment 1

[0013] The present invention is calculated by weight percentage: wolfberry 9%, chrysanthemum 9%, rehmannia glutinosa 29%, wine cornel 15%, moutan bark 12%, yam 10%, poria cocos 8% and Alisma 8%, the total amount is 100% Made as bulk drug, the preparation steps are as follows:

[0014] (1) Take wolfberry fruit, wine cornus and rehmannia glutinosa three flavor raw materials and put them into the liquid nitrogen freezing and grinding room, freeze at -30°C for 15 minutes, put them into the freezing grinder, and grind them at the low temperature of -70°C into a very fine powder through a 75µm aperture sieve;

[0015] (2) Take chrysanthemum, Moutan cortex, Chinese yam, Poria cocos and Alisma, put them in a pulverizer at room temperature and pulverize them into a very fine mixed powder passing through a sieve with an aperture of 75 μm;

[0016] (3) Put the ultra-fine powder and the ultra-fine mixed powder into the cylinder mixer and mix for 30 minutes, put it in a circulating steam ...

Embodiment 2

[0019] The present invention is calculated by weight percentage: 5% medlar, 5% chrysanthemum, 30% Rehmannia glutinosa, 15% wine cornus, 8% moutan cortex, 13% Chinese yam, 12% Poria cocos and 12% Alisma alisma, the total amount is 100% Made as bulk drug, the preparation steps are as follows:

[0020] (1) Take wolfberry fruit, wine cornel and rehmannia glutinosa three raw materials and put them into the liquid nitrogen freezing and grinding room, freeze at -32°C for 15 minutes, put them into the freezing grinder, and grind them at the low temperature of -75°C into a very fine powder through a 75µm aperture sieve;

[0021] (2) Take chrysanthemum, Moutan cortex, Chinese yam, Poria cocos and Alisma, put them in a pulverizer at room temperature and pulverize them into a very fine mixed powder passing through a sieve with an aperture of 75 μm;

[0022] (3) Put the ultra-fine powder and the ultra-fine mixed powder into the cylinder mixer and mix for 30 minutes, put it in a circulatin...

Embodiment 3

[0025] The present invention is calculated by weight percentage: wolfberry 8%, chrysanthemum 7%, rehmannia glutinosa 25%, wine cornus 10%, moutan cortex 11%, yam 15%, poria cocos 12% and Alisma 12%, the total amount is 100% Made as bulk drug, the preparation steps are as follows:

[0026] (1) Take wolfberry fruit, wine cornus and rehmannia glutinosa three raw materials and put them into the liquid nitrogen freezing and grinding room, freeze at -35°C for 15 minutes, put them into the freezing grinder, and grind them at -80°C into a very fine powder through a 75µm aperture sieve;

[0027] (2) Take chrysanthemum, Moutan cortex, Chinese yam, Poria cocos and Alisma, put them in a pulverizer at room temperature and pulverize them into a very fine mixed powder passing through a sieve with an aperture of 75 μm;

[0028] (3) Put the ultra-fine powder and the ultra-fine mixed powder into the cylinder mixer and mix for 30 minutes, put it in a circulating steam sterilizer, sterilize it a...

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Abstract

The invention relates to a preparation method of a barbary wolfberry fruit, florists chrysanthemum flower and adhesive rehmannia root pill by a freeze-grinding technique, and effectively solves the problems that the sugar content of individual medicinal materials is high, the medicinal materials cannot be easily kneaded together and easily stick to a grinding machine, treatment effects are poor, and the content cannot be stably measured. The pill is prepared from, in weight percent, barbary wolfberry fruits, florists chrysanthemum flowers, prepared adhesive rehmannia roots, Asiatic cornelian cherry fruits, subshrubby peony roots and barks, common yam rhizomes, Indian bread and oriental waterplantain rhizomes, and the total weight percent of the materials is 100%. The barbary wolfberry fruits, the Asiatic cornelian cherry fruits and the prepared adhesive rehmannia roots are placed in a liquid nitrogen refrigeration crushing chamber to be frozen and placed into a crushing machine to be crushed, the florists chrysanthemum flowers, the subshrubby peony roots and barks, the common yam rhizomes, the Indian bread and the oriental waterplantain rhizomes are crushed in a normal-temperaturecrushing machine, prepared powder is mixed, sterilized and cooled to obtain sterilized fine powder, water is added into the powder to prepare a water pill, or refine honey and water is sequentially added into the powder to prepare a water-honeyed pill, or refine honey is added into the powder to prepare a large-honey pill. The uniformity, the release amount and the release speed of effective components are high, effective components of medicines are highly absorbed by a human body in unit time, effect taking time is remarkably shortened, and the treatment effects are remarkably improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method for producing Qiju Dihuang Pills by means of freezing and pulverizing technology. Background technique [0002] Qiju Dihuang Wan is recorded in the 2015 edition of the "Chinese Pharmacopoeia". It is made by adding wolfberry and chrysanthemum on the basis of the classic prescription Liuwei Dihuang Wan. It has the effects of nourishing yin, nourishing the liver, and improving eyesight. It is used for liver and kidney yin It is a classic ophthalmology prescription of traditional Chinese medicine. Traditional Chinese medicine believes that the liver opens to the eyes, and the liver blood can be injected into the eyes to see. Lycium barbarum tonifies the kidney and essence, nourishes the liver and improves eyesight; chrysanthemum is good at clearing the head and clearing away the heat of the liver meridian. Rehmannia glutinosa is reused in the prescription to nourish yin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/20A61P1/14A61P1/08A61P27/16A61P27/02
CPCA61K9/2068A61K9/2095A61K36/076A61K36/287A61K36/40A61K36/65A61K36/71A61K36/804A61K36/815A61K36/884A61K36/8945A61K2236/15A61P1/08A61P1/14A61P27/02A61P27/16
Inventor 王粉于夏蔡俊安
Owner 河南百年康鑫药业有限公司
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