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Application of ethyl ammonium sulfate in preparing medicine for preventing or treating inflammatory diseases

A technology of ammonium ethyl sulfate and inflammatory diseases, which is applied in the field of application of ammonium ethyl sulfate in the preparation of drugs for the prevention or treatment of inflammatory diseases, can solve the problems of undiscovered medical uses of ammonium ethyl sulfate, and achieve good results Anti-inflammatory effect

Pending Publication Date: 2019-03-01
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product is etherified with ethanol to obtain anesthesia ether; neutralize ethyl sulfuric acid with ammonia water to obtain ammonium ethyl sulfate, and ammonium ethyl sulfate has not been found to have medical applications.

Method used

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  • Application of ethyl ammonium sulfate in preparing medicine for preventing or treating inflammatory diseases
  • Application of ethyl ammonium sulfate in preparing medicine for preventing or treating inflammatory diseases
  • Application of ethyl ammonium sulfate in preparing medicine for preventing or treating inflammatory diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: the preparation of ammonium ethyl sulfate

[0045] Add a certain amount of ethanol to the reaction kettle, slowly add 6 times the amount of sulfuric acid ethanol solution dropwise under stirring, control the temperature of the reaction kettle at 38°C, and continue stirring for 24 hours for the esterification reaction. Add ethanol, stir well, adjust the pH to 7.0 with 10% ammonia water, add 95% ethanol to make the alcohol content reach more than 85%, recover ethanol under reduced pressure, and separate the aqueous solution through adsorption resin column chromatography, and use water: ethanol gradient elution, The eluate was collected and ammonium ethylsulfate crystallized.

Embodiment 2

[0046]Example 2: Effect of ammonium ethyl sulfate on phorbol ester-induced ear swelling in mice

[0047] experimental method

[0048] ICR mice, male and female, 6-8 weeks old, weighing 18-22 g, were randomly divided into 6 groups (model group, five-dose groups of ammonium ethylsulfate). Use a 20 μL pipette to evenly apply 20 μL of TPA solution to the right ear of each mouse. One hour after modeling, ammonium ethyl sulfate was injected intravenously at a volume of 0.1 mL / 10 g, and the dosages were 12.5, 25, 50, 100, and 200 mg / kg. After 6 hours of modeling, the mice were sacrificed by dislocation of the cervical vertebrae, and round ears were punched in the same part of the two auricles with a punch with a diameter of 8 mm, weighed with an electronic balance, and the swelling degree and swelling inhibition rate of the auricles were calculated according to the following formula. Degree of swelling (%)=(right ear mass−left ear mass) / left ear mass×100%.

[0049] data analysis ...

Embodiment 3

[0057] Example 3: Effect of Ammonium Ethyl Sulfate on Rat Paw Swelling Induced by Carrageenan

[0058] experimental method

[0059] Wistar rats, weighing 200-220 g, were randomly divided into 6 groups (normal group, model group, four dose groups of ammonium ethyl sulfate). After chloral hydrate anesthesia, in addition to the normal group given the same amount of normal saline, the rats in other groups were injected subcutaneously with 0.1 mL of sterile 1% carrageenan normal saline suspension on the right hind paw to cause inflammation, and 0.5 hours after inflammation Different doses of ammonium ethyl sulfate or normal saline were administered intravenously, and the administration volume was 1 mL / 100 g. The water volume method was used to measure the volume of the right hind paw before inflammation and 1, 3, 5, and 7 hours after inflammation, and the swelling rate and swelling inhibition rate were calculated. Swelling rate (%), expressed as (Vt-Vn) / Vn*100, Vn and Vt represen...

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Abstract

The invention discloses application of ethyl ammonium sulfate in preparing a medicine for treating inflammation, fever, diarrhea and cough and being used as an NF-kB inhibitor drug and a preparation method and composition of the ethyl ammonium sulfate.

Description

technical field [0001] The invention relates to the application of ammonium ethyl sulfate in the preparation of medicines for preventing or treating inflammatory diseases. Background technique [0002] Ethyl sulfuric acid is also called ethyl bisulfate or ethyl-sulfuric acid. The boiling point is 280°C (decomposition). The relative density is 1.316. When heated or boiled in concentrated solution, it decomposes into toxic sulfur oxide (SOx) fumes, which are highly irritating and corrosive to skin, eyes and mucous membranes. The product is etherified with ethanol to obtain anesthesia ether; neutralize ethyl sulfuric acid with ammonia water to obtain ammonium ethyl sulfate, and ammonium ethyl sulfate has not been found to have medical applications. Contents of the invention [0003] The applicant unexpectedly found that ammonium ethylsulfate can be used in the preparation of inflammatory diseases, antipyretic, diarrhea or NF-κB inhibitor drugs. [0004] The first object o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/255A61P29/00A61P1/12A61P11/00A61P11/14
CPCA61K31/255
Inventor 黄冰峰崔刚曾君南刘尧奇王振刘地发廖剑桥
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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