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Hydroxyapatite nanorod array structured coating co-doped with multiple elements on titanium-based surface and its preparation method and application

A technology of hydroxyapatite and nanorod arrays, which is applied in the direction of surface reaction electrolytic coating, coating, metal material coating technology, etc., can solve problems such as disorder, no configuration, and poor osseointegration effect

Active Publication Date: 2020-10-27
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many scholars have prepared hydroxyapatite doped with different types of elements by hydrothermal method, but the obtained hydroxyapatite is limited to chaotic hydroxyapatite powder, which has no configuration at all. poor osseointegration effect

Method used

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  • Hydroxyapatite nanorod array structured coating co-doped with multiple elements on titanium-based surface and its preparation method and application
  • Hydroxyapatite nanorod array structured coating co-doped with multiple elements on titanium-based surface and its preparation method and application
  • Hydroxyapatite nanorod array structured coating co-doped with multiple elements on titanium-based surface and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0049] Will contain 0.11M (CH 3 COO) 2 Ca, 0.03M (CH 3 COO) 2 Sr, 0.03M (CH 3 COO) 2 Zn, 0.03M (CH 3 COO) 2 Mg and 0.02M β-C 3 h 7 Na 2 o 6 The aqueous solution of P(β-GP) is used as the electrolyte, and the metal titanium sheet is used as the anode, and the stainless steel is placed as the cathode in the electrolyte; a DC pulse power supply is used at a positive voltage of 400V, a negative voltage of 50V, a frequency of 100Hz, and a duty cycle of 7.5%. 1. Under the conditions of 8 cm distance between cathode and anode plates and electrolyte temperature of 25°C, the titanium sheet was subjected to micro-arc oxidation treatment for 5 minutes to obtain a titanium oxide-based composite layer containing calcium, strontium, magnesium and zinc. Then soak this titanium oxide-based composite layer / titanium sheet sample in a NaOH solution with a concentration of 0.03M in a hydrothermal reactor, and the filling degree of the solution is 15%. It is hydrothermally treated at 140...

Embodiment 2

[0051] Will contain 0.11M (CH 3 COO) 2 Ca, 0.03M (CH 3 COO) 2 Sr, 0.03M (CH 3 COO) 2 Zn, 0.03M (CH 3 COO) 2 Mg and 0.02M β-C 3 h 7 Na 2 o 6 The aqueous solution of P(β-GP) is used as the electrolyte, and the metal titanium sheet is used as the anode, and the stainless steel is placed as the cathode in the electrolyte; a DC pulse power supply is used at a positive voltage of 400V, a negative voltage of 50V, a frequency of 100Hz, and a duty cycle of 7.5%. 1. Under the conditions of 8 cm distance between cathode and anode plates and electrolyte temperature of 25°C, the titanium sheet was subjected to micro-arc oxidation treatment for 5 minutes to obtain a titanium oxide-based composite layer containing calcium, strontium, magnesium and zinc. Then soak this titanium oxide-based composite layer / titanium sheet sample in a NaOH solution with a concentration of 0.03M in a hydrothermal reactor, and the filling degree of the solution is 15%. It is hydrothermally treated at 140...

Embodiment 3

[0053] 0.155M (CH 3 COO) 2 Ca, 0.015M (CH 3 COO) 2 Sr, 0.015M (CH 3 COO) 2 Zn, 0.015M (CH 3 COO) 2 Mg and 0.02M β-C 3 h 7 Na 2 o 6 The aqueous solution of P(β-GP) is used as the electrolyte, and the metal titanium sheet is used as the anode, and the stainless steel is placed as the cathode in the electrolyte; a DC pulse power supply is used at a positive voltage of 400V, a negative voltage of 50V, a frequency of 100Hz, and a duty cycle of 7.5%. 1. Under the conditions of 8 cm distance between cathode and anode plates and electrolyte temperature of 25° C., micro-arc oxidation treatment was carried out on the titanium sheet for 5 minutes to obtain a titanium oxide-based composite layer containing strontium, magnesium and zinc. Then soak this titanium oxide-based composite layer / titanium sheet sample in a NaOH solution with a concentration of 0.03M in a hydrothermal reactor, and the filling degree of the solution is 15%. It is hydrothermally treated at 140°C for 24 hour...

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Abstract

The invention belongs to the technical field of titanium-based surface treatment, and specifically relates to a titanium-based surface multi-element co-doped hydroxyapatite nanorod array configurational coating, a preparation method and the application thereof. A micro-arc oxidation-hydrothermal treatment compound method is used, an HA nanorod array configurational coating in which three elementsof strontium, zinc and magnesium are doped is prepared on the surface of pure titanium, and co-doping of five elements such as Sr, Zn, Mg, Si and C of nanorod-like HA in a coating array is realized bycarrying out second hydrothermal treatment method on the coating. The preparation method is simple in technology and low in production cost, the obtained rod-like hydrothermal treatment gets closer to the bionic component of human bone, the coating can be quickly induced in an environment similar to a body fluid to form bone apatite, and the coating has good biological activity. The coating in combination with a micro-nano structure and biological activity elements preferably stimulates a synergetically enhanced biological effect, a novel design thought is provided for the surface modification of a metal implant, and the coating is significant for efficiently promoting osseointegration.

Description

technical field [0001] The technical field of titanium-based surface treatment, specifically relates to a titanium-based surface multi-element co-doped HA nanorod array patterned coating and its preparation method and application. Background technique [0002] Metal implants (such as titanium) are mostly biologically inert materials, which are easy to form fibrous tissue wrapping in the early stage of implantation, and it is difficult to form a firm bone bond with the host bone, so the surface is modified to enhance its osseointegration with the host bone Function is an important topic in the field of bone repair. Studies have shown that using micro-nano structures and bioactive substances to construct a surface microenvironment suitable for cell / tissue growth is an effective means to promote surface bone tissue formation and osseointegration. Based on this, in the previous research, the applicant prepared a kind of hydroxyapatite (HA) nanorods on the surface of pure titani...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D11/26C23C26/00C23C28/04A61L27/06A61L27/32
CPCA61L27/06A61L27/32A61L2430/02C23C26/00C23C28/042C25D11/26
Inventor 憨勇叶晶
Owner XI AN JIAOTONG UNIV
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