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Gradient porous bone scaffold material and preparation method thereof

A gradient porous, bone scaffolding technology, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problem that high pore structure and high mechanical properties cannot coexist, and achieve controllable pore structure, good osteogenic activity, and mechanical properties Good results

Inactive Publication Date: 2019-02-22
FUJIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a gradient porous bone scaffold material and its preparation method, which can solve the problem that the high porosity structure and high mechanical properties of the scaffold material cannot coexist, and effectively improve the implantation efficiency of the bone scaffold material in the bone defect site. long-term stability

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  • Gradient porous bone scaffold material and preparation method thereof
  • Gradient porous bone scaffold material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) prepare bioactive glass nanopowder and be mixed with suspension;

[0035] (2) respectively dissolving collagen and phosphoserine in glacial acetic acid to prepare a suspension;

[0036] (3) Stir and mix the collagen suspension obtained in step (2) with the phosphoserine suspension;

[0037] (4) Slowly add the bioactive glass suspension obtained in step (1) into the mixed vortex suspension of step (3), mix well, and control the mass ratio of bioactive glass / collagen / phosphoserine to be 65:30: 5. Control the water content of the suspension to obtain a suspension ①, a 60% suspension ②, and a 50% suspension ③ with a water content of 70%.

[0038] (5) The bioactive glass / collagen / phosphoserine gel-like suspension ① prepared in step (4) is injected into the composite scaffold forming mold, and then frozen.

[0039] (6) Take out the mold in step (5), inject the suspension ② on the surface of the solidified suspension, and then freeze; inject the suspension ③ after it sol...

Embodiment 2

[0047] Change the mass ratio of bioactive glass / collagen / phosphoserine in Example 1 to 65:32:3, and control the water content of the suspension to 75%, 65%, and 55%, respectively. The other steps were the same as in Example 1 to prepare a gradient porous bioactive glass / collagen / phosphoserine composite scaffold.

Embodiment 3

[0049] Change the mass ratio of bioactive glass / collagen / phosphoserine in Example 1 to 65:34:1, and control the water content of the suspension to 80%, 70%, and 60%, respectively. The other steps were the same as in Example 1 to prepare a gradient porous bioactive glass / collagen / phosphoserine composite scaffold.

[0050] The compressive strength of the material was tested using a universal testing machine. Such as figure 2 As shown, it can be seen from the curves that all scaffolds go through several stages: linear elastic deformation under small stress, followed by short-term flexural deformation, and finally rapid fracture. Moreover, as the bioglass content increased from 60% to 70%, the ultimate strength and elastic modulus before fracture of the scaffold also increased, indicating that the composition of the scaffold had a significant impact on its mechanical strength. The higher the water content of the suspension, the higher the porosity, which allows the scaffold to ...

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Abstract

The invention relates to a preparation method of a gradient porous bone scaffold material. The preparation method comprises the following steps: (1) preparing nano bioactive glass powder into a suspension solution A; (2) dissolving collagen and auxiliary materials into glacial acetic acid to prepare a suspension solution B; (3) adding the suspension solution A into the suspension solution C to obtain a suspension solution C; obtaining a suspension solution (1), a suspension solution (2) and a suspension solution (3), which have different water contents, respectively; (4) injecting the suspension solution (1) into a mold and freezing; after curing, injecting the suspension solution (2) and freezing; continually injecting the suspension solution (3) and freezing; then carrying out freeze drying; (5) carrying out crosslinking treatment; and (6) freezing and carrying out freeze drying, and finally carrying out sterilization treatment. The invention provides the gradient porous bone scaffold material prepared by the preparation method. By adopting the preparation method of the gradient porous bone scaffold material, the problem that a high-pore structure and a high mechanical property of the scaffold material cannot coexist is solved and the long-period stability of the bone scaffold material which is planted into a bone defect part is effectively improved; and meanwhile, the bone scaffold material is used as a carrier to realize space-time controlled release of loading cells or growth factors or medicines.

Description

technical field [0001] The invention relates to a bone support material and a preparation method thereof, in particular to a gradient porous bone support material and a preparation method thereof. Background technique [0002] Bone defect is a common clinical disease, which is usually caused by various reasons such as congenital deformity, trauma, inflammation, osteoporosis and tumor resection. At present, a large number of studies at home and abroad have confirmed that imitating the composition, structure and function of natural bone tissue, bionic reconstruction of bone tissue engineering scaffold materials in vitro, and compounding them with cells or growth factors is an effective way to treat bone defects. Therefore, the preparation of three-dimensional porous scaffolds is the key to the study of bone defect repair. [0003] From the perspective of material science, bone tissue is a composite material composed of inorganic mineral-hydroxyapatite and organic component-co...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/54A61L27/10A61L27/24A61L27/00A61L27/22A61L27/50
CPCA61L27/00A61L27/10A61L27/227A61L27/24A61L27/50A61L27/54A61L27/56A61L2300/252A61L2300/414A61L2430/02C08L89/00
Inventor 杨春蓉
Owner FUJIAN UNIV OF TECH
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