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A kind of hydrophilic sulindac molecularly imprinted magnetic nano resin ball and its preparation method and application

A magnetic nanosphere, molecular imprinting technology, applied in chemical instruments and methods, other chemical processes, alkali metal compounds, etc., to achieve the effects of strong reusability, strong magnetic response, and high binding capacity

Active Publication Date: 2020-08-18
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are no relevant reports on the preparation of sulindac molecularly imprinted polymers and their application in the direct separation and detection of sulindac in sewage

Method used

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  • A kind of hydrophilic sulindac molecularly imprinted magnetic nano resin ball and its preparation method and application
  • A kind of hydrophilic sulindac molecularly imprinted magnetic nano resin ball and its preparation method and application
  • A kind of hydrophilic sulindac molecularly imprinted magnetic nano resin ball and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0034] A preparation method of hydrophilic sulindac molecularly imprinted magnetic nano-resin balls, comprising the following steps:

[0035] Step 1. Put 0.30g of ferric chloride, 1.00g of sodium acetate, 0.02g of sodium polyacrylate, 6.6mL of ethylene glycol and 10mL of diethylene glycol in a reactor, and react at 180°C for 7 hours. After the reaction, The reaction product was washed with ultrapure water until neutral. Then, the obtained product was vacuum-dried at 30° C. and 0.05 MPa for 3 hours to obtain carboxyl magnetic nanospheres. Such as figure 1 As shown, the particle size of the prepared carboxyl magnetic nanospheres is about 110-120 nm.

[0036] Step 2: Put 100mg of carboxyl magnetic nanospheres, 10mg of sulindac, 5mL of ultrapure water and 1.8mL of ammonia water in a reaction vessel, stir and react at room temperature for 10min, then add 0.01g of resorcinol and stir for 0.5h, and finally add 0.01 mL formaldehyde, polymerized at room temperature for 3 hours, and ...

Embodiment 2

[0048] A preparation method of hydrophilic sulindac molecularly imprinted magnetic nano-resin balls, comprising the following steps:

[0049] Step 1. Put 0.45g of ferric chloride, 1.5g of sodium acetate, 0.03g of sodium polyacrylate, 6.8mL of ethylene glycol and 12mL of diethylene glycol in a reactor, and react at 190°C for 10 hours. After the reaction, The reaction product was washed with ultrapure water until neutral. Then, vacuum-dry the obtained product at 45° C. and 0.05 MPa for 4.5 hours to obtain carboxyl magnetic nanospheres.

[0050] Step 2: Put 110mg of carboxyl magnetic nanospheres, 12mg of sulindac, 6mL of ultrapure water and 1.85mL of ammonia water in a reaction vessel, stir and react at room temperature for 20min, then add 0.04g of resorcinol and stir for 0.8h, and finally add 0.02 mL formaldehyde, polymerized at room temperature for 4 hours, and cured at 20°C for 8 hours.

[0051] Step 3, after the polymerization reaction is completed, the solid polymer genera...

Embodiment 3

[0062] A preparation method of hydrophilic sulindac molecularly imprinted magnetic nano-resin balls, comprising the following steps:

[0063] Step 1. Put 0.504g of ferric chloride, 2.0g of sodium acetate, 0.05g of sodium polyacrylate, 7mL of ethylene glycol and 13mL of diethylene glycol in a reactor, and react at 200°C for 11 hours. After the reaction, put The reaction product was washed with ultrapure water until neutral. Then, vacuum-dry the obtained product at 50° C. and 0.05 MPa for 5.5 hours to obtain carboxyl magnetic nanospheres.

[0064] Step 2: Put 250mg of carboxyl magnetic nanospheres, 20mg of sulindac, 10mL of ultrapure water and 2mL of ammonia water in a reaction vessel, stir and react at room temperature for 30min, then add 0.1g of resorcinol and stir for 1.2h, and finally add 0.05mL Formaldehyde, polymerized at room temperature for 6h, and cured at 25°C for 10h.

[0065] Step 3, after the polymerization reaction is completed, the solid polymer generated in the...

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Abstract

The invention discloses hydrophilic sulindac molecularly imprinted magnetic nanoresin spheres, and a preparation method and an application thereof, and belongs to the technical fields of nanomaterialpreparation and environmental chemistry application. The preparation method comprises the steps: firstly, synthesizing carboxyl magnetic nanospheres by a hydrothermal method in one step; then, addingthe carboxyl magnetic nanospheres and sulindac to ultra-pure water, and followed by adding ammonia water to obtain a template-carrier complex; then adding resorcinol and formaldehyde, and polymerizingto obtain a solid polymer; and finally, separating the solid polymer by an externally applied magnetic field, and eluting and drying the polymer, to obtain the hydrophilic sulindac molecularly imprinted magnetic nanoresin spheres. The prepared hydrophilic sulindac molecularly imprinted magnetic nanoresin spheres have the advantages of uniform particle size, good structural stability, strong magnetic response, strong reusability, good hydrophilicity, strong selective adsorption capacity on sulindac, large adsorption capacity, high recovery rate, low cost of materials and simple preparation.

Description

technical field [0001] The technical field of nanomaterial preparation and environmental chemical application of the present invention relates to a hydrophilic sulindac molecularly imprinted magnetic nano resin ball and its preparation method and application. Background technique [0002] Since the 21st century, with the advancement of science and technology and the changes of the times, the analysis technology of pollutants in the environment is gradually improving, and people's awareness of environmental protection is gradually strengthening. New environmental pollutants——pharmaceuticals and personal care products (PPCPs) began to received widespread attention. There are many types of PPCPs, mainly including various antibiotics, synthetic musk, analgesics, antihypertensive drugs, contraceptives, hypnotics, weight loss drugs, hairspray, hair dye, and fungicides. The chemical structure of PPCPs is generally stable and not easy to degrade, and the PPCPs existing in the envir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G8/22C08J9/28B01J20/26B01J20/28B01J20/30
CPCB01J20/268B01J20/28004B01J20/28009B01J20/28019C08G8/22C08J9/28C08J2361/06
Inventor 高瑞霞王悦赵文昌安金刚唐骁爽张军杰
Owner XI AN JIAOTONG UNIV
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