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A method for synchronous extraction and detection and analysis of multiple drugs in an environmental multi-media

An analysis method and simultaneous extraction technology, applied in the field of environmental analysis, can solve problems such as weak research on accurate quantitative analysis, and achieve the effects of improving sensitivity, reducing mass spectrometry conditions, and improving detection sensitivity

Active Publication Date: 2021-06-04
CENT SOUTH UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, drugs in the environment have different physical and chemical properties and complex matrices, and research on their precise quantitative analysis is still weak. Therefore, future research should develop more portable, efficient, and sensitive pretreatment methods, as well as realize online pretreatment- Combined use of analytical instrumentation detection for accurate quantitation of ultra-trace pharmaceuticals in the environment

Method used

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  • A method for synchronous extraction and detection and analysis of multiple drugs in an environmental multi-media
  • A method for synchronous extraction and detection and analysis of multiple drugs in an environmental multi-media
  • A method for synchronous extraction and detection and analysis of multiple drugs in an environmental multi-media

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Embodiment 1

[0037] (1) Preparation of a single standard solution:

[0038] Standard product ciprofloxacin, enrofloxacin, norfloxacin, ofloxacin, difloxacin, pefloxacin, flumequine and sulfadiazine single standard preparation method: accurately weigh 10 mg of the above-mentioned Standards, respectively dissolved in 10mL methanol solution containing 0.5% (v / v) 0.03M NaOH, diluted with methanol to 100mgL -1 single standard solution.

[0039] Dehydrated erythromycin standard solution preparation method: take 10mL 1000mg L -1 erythromycin standard solution, add 10mL ultrapure water, add a small amount of 3M H 2 SO 4 Adjust the pH to 3, stir at room temperature for 4 hours, and set the volume to 50mL. At this time, the solution concentration is 200mgL -1 .

[0040] Standard tetracycline, chlortetracycline, oxytetracycline, doxycycline, lincomycin, amoxicillin, cefotaxime, clarithromycin, azithromycin, tylosin, chloramphenicol, thiamphenicol, Florfenicol, roxithromycin; sulfathiazole, sulf...

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Abstract

The invention discloses a method for synchronous extraction, detection and analysis of multiple drugs in an environmental multi-media, comprising the following steps: 1) centrifuging sewage to obtain water samples and solid samples; 2) extracting drugs from water samples and solid samples; 3) Extraction of drugs in water samples and solid samples; 4) Qualitative analysis of various drugs in environmental multi-media; 5) Quantitative analysis of various drugs in environmental multi-media. On the basis of completing the extraction of various drugs in environmental multi-media, the method adopts the method of solid-phase extraction and high-performance liquid chromatography-mass spectrometry (LC-MS / MS), and optimizes the chromatographic conditions and detection methods to establish a suitable The analysis method for simultaneous extraction and detection of multiple drugs in environmental multi-media (surface water, sewage treatment plant influent and effluent, sludge and sediment) provides a reliable analysis method for a comprehensive survey of drug content levels and distribution characteristics in complex environments.

Description

technical field [0001] The invention belongs to the field of environmental analysis, and specifically relates to a method for synchronous extraction, detection and analysis of multiple medicines in an environmental multi-media. Background technique [0002] In recent years, drugs have attracted widespread attention as an emerging environmental pollutant, and drug residues (ng L -1 ~μgL -1 ), its long-term large-scale retention in the environment will produce endocrine disrupting effects and threaten human health. People consume a large amount of medicines in daily life, such as various oral medicines, cold medicines and anti-inflammatory medicines. In some areas, especially in rural areas without centralized sewage treatment facilities, direct sewage discharge occurs frequently, becoming one of the most important sources of pharmaceutical pollutants in the environment. Sewage treatment plants are an important "sink" for pharmaceutical pollutants. After the drug is taken ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 李海普姚晶晶林惠菊杨兆光刘博宇
Owner CENT SOUTH UNIV
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