A kind of rare earth phosphate/bioactive polymer three-dimensional porous composite material, its preparation method and application

A technology of rare earth phosphate and polymer materials, applied in the fields of organic bioactive polymer materials, biomedical materials, and inorganic non-metallic materials, can solve problems such as unclear effects, and achieve cell adhesion, high porosity, and cycle time short effect

Active Publication Date: 2021-06-25
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rare-earth metal-based scaffolds such as La have so far been rarely used in biomaterials, and their role in osteogenesis remains unclear

Method used

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  • A kind of rare earth phosphate/bioactive polymer three-dimensional porous composite material, its preparation method and application
  • A kind of rare earth phosphate/bioactive polymer three-dimensional porous composite material, its preparation method and application
  • A kind of rare earth phosphate/bioactive polymer three-dimensional porous composite material, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] (1) 2.9877g La(NO 3 ) 3 ·6H 2 O and 0.9112g (NH 4 ) 2 HPO 4 were dissolved in 100mL deionized water to prepare La(NO 3 ) 3 aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution.

[0060] (2) to (NH 4 ) 2 HPO 4 Add NH to the aqueous solution 3 ·H 2 O adjust the pH to 11.5, then (NH 4 ) 2 HPO 4 The aqueous solution was placed in a 20°C oil bath for mechanical stirring while adding La(NO 3 ) 3 The aqueous solution, after the dropwise addition, was stirred at 90°C for 1 hour, then stirred at 20°C for 24 hours, filtered and washed to obtain a neutral precipitate, dried at 50°C for 12 hours, and calcined at 500°C for 6 hours to obtain lanthanum phosphate (LaPO 4 ) powder with a particle size of 50nm to 5μm.

[0061] (3) Take 100 mL of acetic acid solution with a volume fraction of 1%, add 4.0 g of chitosan, and stir to completely dissolve the chitosan until clear and transparent.

[0062] (4) Add 4.0 g of lanthanum phosphate powder into the chitosan solut...

Embodiment 2

[0072] (1) 2.9877g La(NO 3 ) 3 ·6H 2O and 0.9112g (NH 4 ) 2 HPO 4 were dissolved in 100mL deionized water to prepare La(NO 3 ) 3 aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution.

[0073] (2) to (NH 4 ) 2 HPO 4 Add NH to the aqueous solution 3 ·H 2 O to adjust the pH to 11, the (NH 4 ) 2 HPO 4 The aqueous solution was placed in a 20°C oil bath for mechanical stirring while adding La(NO 3 ) 3 The aqueous solution, after the dropwise addition, was stirred at 70°C for 1 hour, then stirred at 20°C for 24 hours, filtered and washed to obtain a neutral precipitate, dried at 90°C for 5 hours, and calcined at 1000°C for 6 hours to obtain lanthanum phosphate (LaPO 4 ) powder with a particle size of 50nm to 5μm.

[0074] (3) Take 100 mL of acetic acid solution with a volume fraction of 4%, add 2.0 g of collagen, and stir to completely dissolve the collagen until clear and transparent.

[0075] (4) Add 4.0 g of lanthanum phosphate powder into the collagen soluti...

Embodiment 3

[0082] (1) 2.9961g Ce(NO 3 ) 3 ·6H 2 O and 0.9112g (NH 4 ) 2 HPO 4 were dissolved in 100mL deionized water to prepare Ce(NO 3 ) 3 aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution.

[0083] (2) to (NH 4 ) 2 HPO 4 Add NH to the aqueous solution 3 ·H 2 O to adjust the pH to 11, the (NH 4 ) 2 HPO 4 The aqueous solution was placed in an oil bath at 40°C for mechanical stirring while adding Ce(NO 3 ) 3 The aqueous solution, after the dropwise addition, was stirred at 90°C for 2 hours, then stirred at 40°C for 24 hours, filtered and washed to obtain a neutral precipitate, dried at 90°C for 5 hours, and calcined at 1000°C for 3 hours to obtain cerium phosphate (CePO 4 ) powder with a particle size of 50nm to 5μm.

[0084] (3) Take 100 mL of hydrochloric acid solution with a volume fraction of 0.5%, add 4.0 g of collagen, and keep stirring to completely dissolve the collagen until clear and transparent.

[0085] (4) Add 2.0 g of cerium phosphate powder into th...

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Abstract

The invention belongs to the fields of inorganic non-metallic materials, organic bioactive polymer materials, and biomedical materials, and in particular relates to a rare earth phosphate / bioactive polymer three-dimensional porous composite material, its preparation method and application. The flaky structures of the hetero-rare earth phosphate particles adhere to each other to form a three-dimensional penetrating porous structure, and the rare earth phosphate is evenly distributed on the surface and inside of the flaky structures. The preparation method is as follows: after mixing the rare earth phosphate and the acid-containing biologically active macromolecule material solution, freeze-drying; then soaking in alkaline solution, washing until neutral, and freeze-drying to obtain the preparation. Its structure has high porosity and connectivity, good biological activity, biocompatibility, biodegradability, mechanical and mechanical properties, promotes cell adhesion and growth, promotes osteogenesis and osteoinductivity, and has broad clinical application prospects.

Description

technical field [0001] The invention belongs to the fields of inorganic non-metallic materials, organic bioactive polymer materials and biomedical materials, and specifically relates to a rare earth phosphate / bioactive polymer three-dimensional porous composite material, its preparation method and application. Background technique [0002] Repair and reconstruction of bone defects remains a great challenge for clinicians, especially large bone defects caused by trauma, infection, injury or genetic malformation. To overcome this problem, many bone repair materials with bone formation activity and osteoinductive ability have been applied clinically. The most common bone repair materials are tricalcium phosphate (β-TCP), hydroxyapatite (HA), bioactive glass (BG) and chitosan (CS), all of which have good bioactivity and biocompatibility , but its limited osteoinductivity cannot meet the treatment needs of patients with osteoporosis and metabolic disorders. Therefore, the devel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08L5/08C08L89/00C08L67/04C08K3/32A61L27/56A61L27/58A61L27/50A61L27/12A61L27/20
CPCA61L27/12A61L27/20A61L27/50A61L27/56A61L27/58A61L2430/02C08J9/28C08J2305/08C08J2367/04C08J2389/00C08K2003/328C08L5/08
Inventor 郭亚平赵培培柯勤飞郭翠香张川建
Owner SHANGHAI NORMAL UNIVERSITY
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