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Preparation method for medical antibacterial titanium alloy

A technology of antibacterial titanium alloy and metal powder, which is applied in the field of preparation of medical antibacterial titanium alloy, can solve problems such as poor bonding of surrounding body tissues, non-antibacterial preparation process, and mismatching elastic modulus, so as to reduce stress shielding phenomenon and antibacterial Excellent performance and anti-pollution effect

Inactive Publication Date: 2018-12-21
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims at the problems existing in the current clinical application of titanium alloys, such as stress shielding phenomenon, no antibacterial property or complex preparation process, etc., and provides a preparation method of low modulus and high strength medical antibacterial titanium alloy, which can further improve The antibacterial properties of artificial implants, while reducing the "stress shielding phenomenon", solve the problems of poor integration with surrounding body tissues caused by the mismatch of elastic modulus between implants and human body tissues and susceptibility to infection

Method used

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  • Preparation method for medical antibacterial titanium alloy
  • Preparation method for medical antibacterial titanium alloy
  • Preparation method for medical antibacterial titanium alloy

Examples

Experimental program
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Effect test

Embodiment 1

[0024] (1) According to the mass percentages of Ti 56%, Nb 34%, Zr 6%, and Ag 4%, respectively weigh Ti, Nb, and Zr with a purity of 99.95%, 99.99%, 99.95%, and 99.99% in a glove box , Ag powder, put the powder into a ball mill jar for mechanical alloying, seal the powder with absolute alcohol and evacuate to 40Pa, and the average particle size of all powders is 100nm.

[0025] (2) Ball mill the powder prepared in step (1) for 55 hours, take out the mixture of alcohol and powder and put it in a vacuum drying oven, and dry it at 60Pa and 50°C to prepare Ti, Nb, Zr, Ag Mix powder and set aside.

[0026] (3) Put the mixed powder obtained in step (2) into a graphite mold, then put it into a spark plasma sintering furnace, apply an axial pressure of 70MPa, sinter under a vacuum of 8Pa, and heat up at a rate of 100°C / min Raise the temperature to 800°C, then raise the temperature to 950°C at a rate of 50°C / min, keep it warm for 4 minutes, and then continue to cool to room temperatur...

Embodiment 2

[0029] (1) According to the mass percentages of Ti 62%, Nb 24%, Zr 5%, and Ag 9%, respectively weigh Ti, Nb, and Zr with a purity of 99.95%, 99.99%, 99.95%, and 99.99% in a glove box , Ag powder, put the powder into a ball mill jar for mechanical alloying, seal the powder with absolute alcohol and evacuate to 50Pa, and the average particle size of all powders is 25 μm.

[0030] (2) Ball mill the powder prepared in step (1) for 60 hours, take out the mixture of alcohol and powder and put it in a vacuum drying oven, and dry it at 40Pa and 45°C to prepare Ti, Nb, Zr, Ag Mix powder and set aside.

[0031] (3) Put the mixed powder obtained in step (2) into a graphite mold, then put it into a spark plasma sintering furnace, apply an axial pressure of 70MPa, and sinter under a vacuum of 5Pa, with a heating rate of 100°C / min Raise the temperature to 800°C, then raise the temperature to 960°C at a rate of 50°C / min, keep it warm for 3 minutes, and then continue to cool to room temperat...

Embodiment 3

[0034] (1) According to the mass percentages of Ti 52%, Nb 38%, Zr 8%, and Ag 2%, respectively weigh Ti, Nb, and Zr with a purity of 99.95%, 99.99%, 99.95%, and 99.99% in a glove box , Ag powder, put the powder into a ball mill jar for mechanical alloying, seal the powder with absolute alcohol and evacuate to 30Pa, and the average particle size of all powders is 20 μm.

[0035] (2) Ball mill the powder prepared in step (1) for 50 hours, take out the mixture of alcohol and powder and put it in a vacuum drying oven, and dry it at 50Pa and 50°C at low temperature to prepare Ti, Nb, Zr, Ag The mixed powder, set aside.

[0036](3) Put the mixed powder obtained in step (2) into a graphite mold, then put it into a spark plasma sintering furnace, apply an axial pressure of 60MPa, sinter under a vacuum of 10Pa, and heat up at a rate of 100°C / min Raise the temperature to 800°C, then raise the temperature to 1000°C at a rate of 50°C / min, keep it warm for 2 minutes, and then continue to ...

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Abstract

The invention discloses a preparation method for a medical antibacterial titanium alloy and belongs to the technical field of biomedical material preparation. The method comprises the following stepsthat Ti power, Nb power, Zr power and Ag powder are weighed according to the mass percentages of 52-62% of Ti, 15-38% of Nb, 5-13% of Zr and 2-10% of Ag; all the powder is put into a ball milling tankfor ball milling; the powder is taken out after ball milling and dried at low temperature, and the mixed powder is obtained; the mixed powder is put into a graphite mold and then put into a dischargeplasma sintering furnace, axial pressure of 60-70 MPa is applied, sintering is carried out at the vacuum degree of 2-10 Pa, the temperature is increased to the sintering temperature of 900-1,000 DEGC, the temperature is kept for 2-5 minutes, then the vacuum is kept continuously, the temperature is lowered to the room temperature, and the Ti-Nb-Zr-Ag alloy is obtained. The prepared Ti-Nb-Zr-Ag alloy has low elastic modulus (38-49 GPa) and high strength (880-1,200 MPa) and is antibacterial.

Description

technical field [0001] The invention relates to a preparation method of medical antibacterial titanium alloy, which belongs to the technical field of preparation of biomedical materials. Background technique [0002] Titanium and titanium alloys have the characteristics of high specific strength, low elastic modulus and good corrosion resistance, especially excellent biocompatibility. In recent years, they have gradually become ideal functions for human hard tissue repair and replacement in clinical medicine. Structural materials. However, titanium and titanium alloys currently used clinically do not have antibacterial properties, which inevitably lead to bacterial infections during surgical transplantation. In the United States, where the medical level is relatively high, bacterial infections caused by the use of medical devices The ratio is very high, and involves many clinical applications, including cardiovascular intervention, orthopedics, plastic surgery, stomatology,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C14/00C22C1/04B22F3/105B22F9/04
CPCC22C1/0458C22C14/00B22F3/105B22F9/04B22F2999/00B22F2998/10B22F2003/1051B22F2009/043B22F2201/20
Inventor 何正员胡红艳柯尊瑜蒋业华
Owner KUNMING UNIV OF SCI & TECH
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