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Application of levofloxacin hydrochloride in preparing pesticide preparation for preventing and controlling tobacco bacterial wilt

A technology of levofloxacin hydrochloride and tobacco bacterial wilt, applied in the field of economic crop disease prevention and control, can solve the problems of inconspicuous control effect, poor continuous control effect, unstable application effect, etc., and achieve obvious preventive effect, rapid bactericidal effect, and disease suppression and the remarkable effect of disease prevention

Active Publication Date: 2018-11-23
PLANT PROTECTION RES INST OF GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zhou Kaikai (2016) used 1000-1200 times liquid of 3% Zhongshengmycin WP to control tobacco bacterial wilt, and the control effect reached more than 63%, but the actual application effect in the field was unstable and poor
Antibacterial control agents are widely used because they are easily absorbed by plants and have antibacterial effects. Commonly used are streptomycin sulfate, etc., but tobacco bacterial wilt generally occurs seriously in acidic soil, and acidic soil can promote streptomycin to quickly Hydrolysis, resulting in ineffective control (Ye Jianru, 2013)
Copper ions in copper preparations have a contact killing effect on bacteria, and have been widely used in the prevention and treatment of bacterial leaf spot, and have a long lasting effect, but their weakness is that they are difficult to be absorbed by plants into the body, and the continuous control becomes worse

Method used

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  • Application of levofloxacin hydrochloride in preparing pesticide preparation for preventing and controlling tobacco bacterial wilt
  • Application of levofloxacin hydrochloride in preparing pesticide preparation for preventing and controlling tobacco bacterial wilt
  • Application of levofloxacin hydrochloride in preparing pesticide preparation for preventing and controlling tobacco bacterial wilt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Selection of disintegrant in the preparation of levofloxacin hydrochloride water dispersible granules

[0030] Test disintegrants: ammonium sulfate, urea, sodium chloride, sodium bicarbonate

[0031] Weigh 70g of the technical levofloxacin hydrochloride (Zhuhai Jiayi Biotechnology Co., Ltd.), add 2g, 4g, 6g of each test disintegrant, and then add filler talcum powder to make up to 95g, mix it evenly, and crush it with a jet mill Reach the particle size of 1000 mesh, then place it in a fluidized bed granulator, add 5g soluble starch (Tianjin Damao Chemical Reagent Factory) and 3g water, granulate, dry, and sieving to obtain levofloxacin hydrochloride water with a diameter of 0.8mm Disperse granular samples.

[0032] At 25℃, add 0.5g of sample particles to a 100ml graduated cylinder with a stopper (cylinder height 22.5cm, inner diameter 28mm) containing 90ml of distilled water, plug the mouth of the cylinder, clamp the middle of the graduated cylinder, and rotate alo...

Embodiment 2

[0037] Example 2 Selection of wetting agent in the preparation of levofloxacin hydrochloride water dispersible granules

[0038] Test wetting agent: sodium lauryl sulfate, sodium lauryl sulfonate, sodium alkyl succinate sulfonate (Haian Petrochemical Plant in Jiangsu Province), open powder, sodium dibutyl naphthalene sulfonate .

[0039] Weigh 72g of levofloxacin hydrochloride original drug, add 2.5g, 5g, 7.5g of each test wetting agent, add 4g of urea as disintegrant, use filler talcum powder to make up to 96g, mix evenly, pulverize by jet mill Reach the particle size of 1000 mesh, then place it in a fluidized bed granulator, add 4g of soluble starch (Tianjin Damao Chemical Reagent Factory) and 3g of water, granulate, dry, and sieving to obtain levofloxacin hydrochloride with a diameter of 0.8mm Water dispersible granules sample.

[0040] Add 500ml of 342mg / L hardness water (weigh CaCl 2 0.304g and MgCl 2 ·6H 2 O 0.139g in a 1000mL volumetric flask, dissolve and dilute with distil...

Embodiment 3

[0044] Example 3 Selection of dispersant in the preparation of levofloxacin hydrochloride water dispersible granules

[0045] Test dispersant: sodium lignosulfonate, calcium lignosulfonate, sodium methylene dinaphthalene sulfonate (NNO), ionic polycarboxylate GY-D04 (Beijing Guangyuan Yinong Chemical Co., Ltd.), ion Shape polycarboxylate SD-816 (Beijing Guangyuan Yinong Chemical Co., Ltd.).

[0046] Weigh 70g of levofloxacin hydrochloride original drug, add 4g of urea as a disintegrant, 5g of sodium dibutyl naphthalene sulfonate as a wetting agent, add 2.5g, 5g, 7.5g of each test dispersant, and add filler talcum powder, supplement After mixing it evenly, it is pulverized by a jet mill to reach a particle size of 1000 mesh, and then placed in a fluidized bed granulator, 5g soluble starch (Tianjin Damao Chemical Reagent Factory) and 3g water are added, granulated and dried , Sieving to obtain a sample of levofloxacin hydrochloride water dispersible granules with a diameter of 0.8mm...

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PUM

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Abstract

The invention discloses the application of levofloxacin hydrochloride in preparing a pesticide preparation for preventing and controlling tobacco bacterial wilt. The levofloxacin hydrochloride can beused for preparing water-dispersible granules for preventing and controlling tobacco bacterial wilt. The water-dispersible granules are prepared from the following components in percentage by mass: 70-72% of levofloxacin hydrochloride, 2-6% of a disintegrant, 2.5-7.5% of a wetting agent, 2.5-7.5% of a dispersant, 3-5% of a binder, and 2-20% of a filler. In the invention, the water-dispersible granules containing levofloxacin hydrochloride are prepared by mixing the levofloxacin hydrochloride raw drug, the wetting agent, the dispersant, the disintegrant and the filler uniformly to obtain a premix; pulverizing the premix, adding the binder and water, and performing granulation and drying on mixture. The water-dispersible granules containing levofloxacin hydrochloride prepared by the invention have rapid bactericidal action on tobacco bacterial wilt pathogens and can be sprayed in the regular period or initial period of tobacco bacterial wilt to prevent the occurrence and spreading of diseases, and the disease prevention effect is good.

Description

Technical field [0001] The invention belongs to the field of prevention and control of economic crop diseases, and particularly relates to the application of levofloxacin hydrochloride in the preparation of pesticide preparations for preventing and treating tobacco bacterial wilt. Background technique [0002] Tobacco is one of the important economic crops in our country, and it plays a prominent role in developing local economy and increasing national financial accumulation. In my country's Henan, Shandong, Yunnan, Guizhou and other concentrated tobacco-producing areas, the area of ​​tobacco planting generally only accounts for 1 / 4 of the total cultivated land, while the economic income of tobacco accounts for more than 50% of the entire agricultural income, which is called "get rich" by farmers "Short, flat and fast" crops. [0003] Tobacco wilt is a major worldwide disease caused by Ralstonia solanacearum, which is serious in the southern tobacco areas of Guizhou, Sichuan, Henan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/14A01P1/00
CPCA01N25/14A01N43/90
Inventor 沈会芳林壁润蒲小明张景欣孙大元
Owner PLANT PROTECTION RES INST OF GUANGDONG ACADEMY OF AGRI SCI
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