Application of levofloxacin hydrochloride in preparing pesticide preparation for preventing and controlling tobacco bacterial wilt
A technology of levofloxacin hydrochloride and tobacco bacterial wilt, applied in the field of economic crop disease prevention and control, can solve the problems of inconspicuous control effect, poor continuous control effect, unstable application effect, etc., and achieve obvious preventive effect, rapid bactericidal effect, and disease suppression and the remarkable effect of disease prevention
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0029] Example 1: Selection of disintegrant in the preparation of levofloxacin hydrochloride water dispersible granules
[0030] Test disintegrants: ammonium sulfate, urea, sodium chloride, sodium bicarbonate
[0031] Weigh 70g of the technical levofloxacin hydrochloride (Zhuhai Jiayi Biotechnology Co., Ltd.), add 2g, 4g, 6g of each test disintegrant, and then add filler talcum powder to make up to 95g, mix it evenly, and crush it with a jet mill Reach the particle size of 1000 mesh, then place it in a fluidized bed granulator, add 5g soluble starch (Tianjin Damao Chemical Reagent Factory) and 3g water, granulate, dry, and sieving to obtain levofloxacin hydrochloride water with a diameter of 0.8mm Disperse granular samples.
[0032] At 25℃, add 0.5g of sample particles to a 100ml graduated cylinder with a stopper (cylinder height 22.5cm, inner diameter 28mm) containing 90ml of distilled water, plug the mouth of the cylinder, clamp the middle of the graduated cylinder, and rotate alo...
Embodiment 2
[0037] Example 2 Selection of wetting agent in the preparation of levofloxacin hydrochloride water dispersible granules
[0038] Test wetting agent: sodium lauryl sulfate, sodium lauryl sulfonate, sodium alkyl succinate sulfonate (Haian Petrochemical Plant in Jiangsu Province), open powder, sodium dibutyl naphthalene sulfonate .
[0039] Weigh 72g of levofloxacin hydrochloride original drug, add 2.5g, 5g, 7.5g of each test wetting agent, add 4g of urea as disintegrant, use filler talcum powder to make up to 96g, mix evenly, pulverize by jet mill Reach the particle size of 1000 mesh, then place it in a fluidized bed granulator, add 4g of soluble starch (Tianjin Damao Chemical Reagent Factory) and 3g of water, granulate, dry, and sieving to obtain levofloxacin hydrochloride with a diameter of 0.8mm Water dispersible granules sample.
[0040] Add 500ml of 342mg / L hardness water (weigh CaCl 2 0.304g and MgCl 2 ·6H 2 O 0.139g in a 1000mL volumetric flask, dissolve and dilute with distil...
Embodiment 3
[0044] Example 3 Selection of dispersant in the preparation of levofloxacin hydrochloride water dispersible granules
[0045] Test dispersant: sodium lignosulfonate, calcium lignosulfonate, sodium methylene dinaphthalene sulfonate (NNO), ionic polycarboxylate GY-D04 (Beijing Guangyuan Yinong Chemical Co., Ltd.), ion Shape polycarboxylate SD-816 (Beijing Guangyuan Yinong Chemical Co., Ltd.).
[0046] Weigh 70g of levofloxacin hydrochloride original drug, add 4g of urea as a disintegrant, 5g of sodium dibutyl naphthalene sulfonate as a wetting agent, add 2.5g, 5g, 7.5g of each test dispersant, and add filler talcum powder, supplement After mixing it evenly, it is pulverized by a jet mill to reach a particle size of 1000 mesh, and then placed in a fluidized bed granulator, 5g soluble starch (Tianjin Damao Chemical Reagent Factory) and 3g water are added, granulated and dried , Sieving to obtain a sample of levofloxacin hydrochloride water dispersible granules with a diameter of 0.8mm...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com