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Copper coordination polymer containing nitrogen oxidation functional group as well as preparation method and application of copper coordination polymer

A technology of functional groups and polymers, which is applied in the field of bionic simulation of functional coordination polymers, can solve the problems of poor solubility, high molecular weight, and poor stability, and achieve low toxicity, small relative molecular weight, and high thermal stability. Effect

Inactive Publication Date: 2018-11-16
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a copper coordination polymer containing nitrogen oxidation functional groups and its preparation method and application, to overcome the shortcomings of traditional SOD simulants with large relative molecular weight, poor stability, high toxicity and poor solubility

Method used

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  • Copper coordination polymer containing nitrogen oxidation functional group as well as preparation method and application of copper coordination polymer
  • Copper coordination polymer containing nitrogen oxidation functional group as well as preparation method and application of copper coordination polymer
  • Copper coordination polymer containing nitrogen oxidation functional group as well as preparation method and application of copper coordination polymer

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preparation example Construction

[0028] The preparation method of the copper coordination polymer containing nitrogen oxide functional groups comprises the following steps:

[0029] 1) Dissolve 0.01 mol of isonicotinic acid in a mixture of 16 mL of glacial acetic acid and 16 mL of 30% hydrogen peroxide by mass, and transfer it into a 50 mL round bottom flask, 105 o Heat and stir at C, reflux for 3 h, cool at room temperature, filter and wash with a Buchner funnel to obtain a white powdery solid, which is the nitrogen oxide isonicotinic acid ligand;

[0030] 2) Add o-phenanthroline and isonicotinic acid nitroxide in a molar ratio of (1-2):1 to a mixed solvent composed of water and methanol, the volume ratio of water and methanol is 1: (1-2), heat Stir for 30 minutes, wherein the molar ratio of nitrogen oxide isonicotinic acid to methanol is 1: (300-500);

[0031] 3) Add 1M NaOH dropwise to the mixed solution in step 2) to completely deprotonate the nitrogen oxidized isonicotinic acid, continue to heat and sti...

Embodiment 1

[0036] A copper coordination polymer containing nitrogen oxide functional groups, the preparation method comprising the following steps:

[0037] 1) Weigh 1.23 g (0.01 mol) of the raw material isonicotinic acid and dissolve it in a mixture of 16 mL of glacial acetic acid and 16 mL of 30% hydrogen peroxide, transfer it into a 50 mL round bottom flask, 105 o Heated and stirred at C, refluxed for 3 h, cooled at room temperature, filtered and washed with a Buchner funnel to obtain a white powdery solid, i.e. isonicotinic acid nitroxide ligand, with a yield of 75%;

[0038] 2) Add o-phenanthroline and isonicotinic acid nitric oxide to a mixed solvent composed of water and methanol (volume ratio 1:2) in a molar ratio of 1:2, heat and stir for 30 minutes, wherein the nitrogen oxide isonicotinic acid and methanol The molar ratio is 1:300;

[0039] 3) Add 1M NaOH dropwise to the mixed solution of 1) to completely deprotonate the nitric acid isonicotinic acid, continue to heat and stir...

Embodiment 2

[0043] A copper coordination polymer containing nitrogen oxide functional groups, the preparation method comprising the following steps:

[0044] 1) Weigh 1.23 g (0.01 mol) of the raw material isonicotinic acid and dissolve it in a mixture of 16 mL of glacial acetic acid and 16 mL of 30% hydrogen peroxide, transfer it into a 50 mL round bottom flask, 105 o Heated and stirred at C, refluxed for 3 h, cooled at room temperature, filtered and washed with a Buchner funnel to obtain a white powdery solid, i.e. isonicotinic acid nitroxide ligand, with a yield of 75%;

[0045] 2) Add o-phenanthroline and isonicotinic acid nitroxide to a mixed solvent composed of water and methanol (volume ratio 1:1) at a molar ratio of 1:1, heat and stir for 30 minutes, wherein the nitrogen oxide isonicotinic acid and methanol The mol ratio is 1: 500;

[0046] 3) Add 1M NaOH dropwise to the mixed solution of 1) to completely deprotonate the nitric acid isonicotinic acid, continue to heat and stir for...

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Abstract

The invention relates to a copper coordination polymer containing a nitrogen oxidation functional group as well as a preparation method and application of the copper coordination polymer. The polymerhas a chemical formula of [Cu(INO)(phen)Cl.2H2O]n, wherein INO is a nicotinic acid N-oxide ligand, and phen is chelated nitrogen-containing auxiliary ligand phenanthroline. The preparation method provided by the invention is simple, high-efficiency and friendly to the environment, and has low costs, and the product has a higher yield and higher purity; and as a SOD simulant substance, the polymerhas higher activity of catalyzing a disproportionation reaction of superoxide ions, and very good application prospects.

Description

technical field [0001] The invention belongs to the field of preparation of bionic simulation of functional coordination polymers, and in particular relates to a copper coordination polymer containing nitrogen oxide functional groups and its preparation method and application. Background technique [0002] In the metabolic process of aerobic organisms, more than 5% of the inhaled oxygen is reduced by one electron in the organism to produce chemically active substances—reactive oxygen species (ROS). ROS has high activity and strong oxidation ability. An appropriate amount of ROS can act as a cell signal transduction and gene expression regulatory molecule to regulate cell growth, survival and apoptosis; but too much ROS will attack any molecule it encounters through oxidation, thereby causing damage to cell structure and function. damage, eventually leading to aging and even cancer. In living systems, superoxide dismutase (SOD) can specifically remove superoxide ion free ra...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61P39/02
CPCA61P39/02C08G83/008
Inventor 康祎璠靳猛曹俊祺李远峰思甜甜王肖
Owner SHAANXI UNIV OF SCI & TECH
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