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Porous tissue plugging material and preparation method and plugging product

A technology for plugging materials and porous tissues, which can be used in medical formulations, surgery, drug delivery, etc. It can solve the problem that the speed and volume of hemostasis cannot meet the requirements of emergency treatment, the leakage of liquid cannot be quickly stopped, and the adhesion of hemostatic materials is poor, etc. problems, to achieve excellent adhesion properties, good biocompatibility, and easy molding

Active Publication Date: 2021-03-12
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Based on the above-mentioned technical problems in the prior art, for example: the hemostatic material has poor adhesion and is easy to fall off from the wound; Meet the requirements of emergency treatment when a large amount of rapid bleeding; liquid leakage cannot be stopped quickly; bursting strength is low, etc.

Method used

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  • Porous tissue plugging material and preparation method and plugging product

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no. 1 approach

[0044] Such as figure 1 As shown, in the first embodiment of the present invention, a porous tissue plugging material is provided, including: a matrix 1, the matrix 1 at least partially has a porous structure, and the average pore diameter of the matrix 1 is 50 μm-200 μm, a porosity of 80%-96%; and a wet adhesion layer 2 existing on at least one surface of the substrate 1, and the wet adhesion layer 2 is obtained by contacting at least one surface of the substrate 1 with an adhesion solution.

[0045]The burst strength of the porous tissue plugging material of the present invention is between 0.1Kpa-50Kpa, for example: it can be 1Kpa-50Kpa, it can also be 10Kpa-40Kpa, it can also be 20Kpa-30Kpa; the porous tissue plugging material of the present invention The elongation at break is between 0.1%-300%, can be 1%-300%, can also be 10%-250%, can also be 100%-200%. The water absorption rate of the porous tissue plugging material of the present invention is between 100%-2500%, for...

no. 2 approach

[0068] In the second embodiment of the present invention, a method for preparing a porous tissue plugging material is provided, including the step of composite molding the substrate and the wet adhesion layer, wherein,

[0069] The matrix at least partially has a porous structure, the average pore diameter of the matrix is ​​50 μm-200 μm, and the porosity is 80%-96%;

[0070] The wet adhesive layer is obtained by contacting at least one surface of the substrate with an adhesive solution;

[0071] The adhesion solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer.

[0072] In the present invention, the substrate may be ready-made, or the pre-prepared finished substrate may be directly compounded with the wet adhesive layer.

[0073] In the present invention, the preparation method of the matrix includes: performing cross-linking treatment on the matrix solution, and obtaining the matrix through a freeze-drying process. The solute ...

no. 3 approach

[0092] In the third embodiment of the present invention, a plugging product is provided, including the porous tissue plugging material according to the first embodiment, or the porous tissue plugging material obtained according to the preparation method of the porous tissue plugging material according to the second embodiment. blocking material.

[0093] In the occlusive article of the present invention, optionally, there is a backing layer on the side of the substrate that does not have a wet-state adhesive layer, and a peelable layer on the wet-state adhesive layer. In the present invention, the purpose of setting the peelable layer is to keep the wet adhesive layer with a certain humidity and not be affected by other substances. The present invention does not specifically limit the materials of the backing layer and the peelable layer, as long as they do not affect the function of the plugging product of the present application.

[0094] The occlusion product of the presen...

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Abstract

The invention provides a porous tissue plugging material, a preparation method and a plugging product thereof. The porous tissue plugging material comprises: a matrix having a porous structure at least in part, the average pore diameter of the matrix is ​​50 μm-200 μm, and the porosity is 80%-96%; The wet adhesion layer is obtained by contacting at least one surface of the substrate with an adhesion solution, the adhesion solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer in liquid. The porous tissue plugging material of the present invention has excellent adhesion performance, bursting strength and suitable elongation at break, and can effectively bond with the surface of a living body or a surface of a substantial organ. At the same time, the matrix of the porous tissue plugging material of the present invention has a large porosity, which can quickly absorb liquid, which is beneficial to keep the wound surface relatively dry, so as to better maintain the adhesion performance of the plugging material.

Description

technical field [0001] The invention relates to a porous tissue plugging material, a preparation method thereof and a plugging product, belonging to the field of medical implant materials. Background technique [0002] Tissue closure, such as: hemostasis closure, interstitial fluid leakage closure, etc., is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. Effective hemostasis is the key to relieving patients' suffering and reducing mortality, and rapid and effective hemostasis has become the focus of solving this problem. In daily life, it is inevitable to encounter damage to body tissues caused by various unexpected accidents and disasters. [0003] At present, common hemostatic materials include microporous inorganic materials (zeolites), microporous starch, fibrin glue, gelatin sponge, carboxymethylcellulose soluble hemostatic gauze, α-cyanoacrylate tiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/08A61L24/04A61L24/10
CPCA61L24/001A61L24/0036A61L24/0042A61L24/046A61L24/08A61L24/102A61L24/104A61L2400/12C08L5/04C08L79/02C08L5/08C08L1/284
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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