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A titanium alloy for bone fixation device with osteoinductive activity

A technology for fixation devices and titanium alloys, applied in the field of titanium alloys for bone fixation devices, can solve the problems of unresolved wear resistance, unguaranteed bonding strength, and lack of osteoinductive activity, so as to improve thermodynamic stability and strengthen bone Growth activity, good osteoinductive activity effect

Inactive Publication Date: 2019-11-26
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the application of new titanium alloy medical materials has the following disadvantages: ①No osteoinductive activity; ②Titanium alloy has poor wear resistance. During use, it will cause wear and tear due to human joint activities, and the resulting debris will cause tissue reactions.
[0005] The domestic patent application No. 201510508585.2 discloses a preparation method of a medical bone fixation device, but does not solve the problem of wear resistance; the application No. 201710979298.9 discloses a medical titanium alloy and its preparation method, which has good wear resistance but does not have Osteoinductive activity; application number 201510476616.0 published a medical titanium alloy rod, and application number 201510476615.6 published a medical titanium alloy rod with strong antibacterial ability. Both patented technologies are coated on the outer layer of the titanium alloy rod coating, bond strength cannot be guaranteed

Method used

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  • A titanium alloy for bone fixation device with osteoinductive activity

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1) Ingredients: by mass percentage: Zn 4.5%, Fe 3%, Mo 0.75%, Sr 0.5%, Se 0.5%, Mn 0.5%, Cu0.3%, nano silver wire 1.8%, ZrO 2 8.2%, K 2 CO 3 0.6%, B 0.7%, Zr 15%, carbon nanotube 0.2%, the balance is Ti;

[0019] 2) Preparation of master alloy: the master alloy has two kinds of I and II; the master alloy I is made of nano-silver wire and ZrO 2 Sintering preparation, the nano-silver wire diameter is 80nm, the ZrO 2 The particle size of the particles is 0.3 μm, and they are sintered in a vacuum induction furnace at a temperature of 600-660°C and a time of 30-45 minutes; the master alloy II is composed of K 2 CO 3 , B, Zr, and carbon nanotubes, smelted in a vacuum induction furnace at a temperature of 1800-1850°C, and poured into a graphite mold after holding for 2 hours to obtain an alloy ingot;

[0020] 3) Smelting and casting: Put Zn, Fe, Mo, Sr, Se, Mn, Cu, master alloy I, master alloy II, Ti and other raw materials into the non-consumable electrode water-cooled...

Embodiment 2

[0025] 1) Ingredients: by mass percentage: Zn 5%, Fe 3.5%, Mo 0.8%, Sr 0.6%, Se 0.5%, Mn 0.6%, Cu 0.35%, nano silver wire 1.8%, ZrO 2 8.2%, K 2 CO 3 0.6%, B 0.7%, Zr 15%, carbon nanotube 0.25%, the balance is Ti;

[0026] 2) Preparation of master alloy: the master alloy has two kinds of I and II; the master alloy I is made of nano-silver wire and ZrO 2 Sintering preparation, the nano-silver wire diameter is 90nm, the ZrO 2 The particle size of the particles is 0.35 μm, which is sintered in a vacuum induction furnace at a temperature of 600-660°C and a time of 30-45 minutes; the master alloy II is composed of K 2 CO 3 , B, Zr, and carbon nanotubes, smelted in a vacuum induction furnace at a temperature of 1800-1850°C, and poured into a graphite mold after holding for 2 hours to obtain an alloy ingot;

[0027] 3) Smelting and casting: Put Zn, Fe, Mo, Sr, Se, Mn, Cu, master alloy I, master alloy II, Ti and other raw materials into the non-consumable electrode water-cooled ...

Embodiment 3

[0032] 1) Ingredients: by mass percentage: Zn 5.5%, Fe 4.8%, Mo 0.8%, Sr 0.5%, Se 0.5%, Mn 0.5%, Cu0.3%, nano silver wire 1.8%, ZrO 2 8.2%, K 2 CO 3 0.6%, B 0.9%, Zr 18%, carbon nanotube 0.4%, the balance is Ti;

[0033]2) Preparation of master alloy: the master alloy has two kinds of I and II; the master alloy I is made of nano-silver wire and ZrO 2 Sintering preparation, the nano-silver wire diameter is 100nm, the ZrO 2 The particle size of the particles is 0.5 μm, which is sintered in a vacuum induction furnace at a temperature of 600-660°C and a time of 30-45 minutes; the master alloy II is composed of K 2 CO 3 , B, Zr, and carbon nanotubes, smelted in a vacuum induction furnace at a temperature of 1800-1850°C, and poured into a graphite mold after holding for 2 hours to obtain an alloy ingot;

[0034] 3) Melting and casting: put Ca, Zn, Fe, Mo, Sr, Se, Mn, Cu, master alloy I, master alloy II, Ti and other raw materials into the non-consumable electrode water-cooled...

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Abstract

The invention provides a titanium alloy for bone fixation device with osteoinductive activity. %~1.0%, Se 0.5%~1.2%, Mn 0.4%~1.0%, Cu 0.2%~0.8%, nano silver wire 1.8%, ZrO 2 8.2%, K 2 CO 3 0.5% to 1.2%, B 0.6% to 1.2%, Zr 12% to 20%, carbon nanotubes 0.2% to 0.5%, and the balance is Ti; the preparation process of the present invention includes first preparing the master alloy I (by nano silver wire and ZrO 2 sintered) and master alloy II (by K 2 CO 3 , B, Zr, carbon nanotubes are smelted), and then other raw materials are melted together with master alloys Ⅰ and Ⅱ and then cast into shape, and corresponding heat treatment is carried out. The obtained titanium alloy has excellent mechanical properties and good osteoinductive activity. and antibacterial function.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, in particular to a titanium alloy for bone fixation devices with osteoinductive activity. Background technique [0002] With the development of modern medicine and materials science, metal materials have become the most widely used clinical implant materials due to their good mechanical properties and processing properties. Bone fixation devices are medical devices implanted in the human body. The metal materials used to manufacture bone fixation devices mainly include cobalt alloys, nickel-chromium alloys, and titanium alloys. Titanium alloys have been widely used for their excellent mechanical properties and good biocompatibility. [0003] However, the application of new titanium alloy medical materials has the following disadvantages: ①No osteoinductive activity; ②Titanium alloy has poor wear resistance. During use, it will be worn due to human joint activities, and the resultin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C14/00C22C1/03C22C1/10C22C26/00C22F1/18
CPCC22C1/1036C22C14/00C22C26/00C22F1/183C22C2026/002C22C1/1047
Inventor 周南刘小康汪济海张翼王文刚王伟伟李峰王峥
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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