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Preparation method of sandwich-type composite film stent

A production method and a sandwich-style technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of spinal cord compression, loss of spinal cord cells, and low drug loading, so as to achieve easy degradation, improve efficacy, and avoid further losses Effect

Inactive Publication Date: 2018-10-30
无锡市锡山人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first object of the present invention is to provide a new drug-carrying system for spinal cord treatment, avoiding the need to treat undamaged nerve cells and damaged (but not dead) neurons in the background when using the traditional drug-carrying system in the background art. The nerve cells are removed to cause further loss of spinal cord cells; the second is to provide a new drug-loading system to solve the problem of directional drug release and low drug-loading capacity; the third is to provide a new drug-loading system , to solve the problem that drug release cannot run through the repair process of spinal cord injury; the fourth is to provide a new drug-loading system to solve the problem that the existing drug-loading system is too large and may compress the spinal cord, and it is also conducive to suturing the dura mater

Method used

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  • Preparation method of sandwich-type composite film stent
  • Preparation method of sandwich-type composite film stent
  • Preparation method of sandwich-type composite film stent

Examples

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preparation example Construction

[0050] The concrete preparation method of the present invention is:

[0051] (1) Polylactic acid with a certain molecular weight (mass average molecular weight is 5000-1000000, preferably 5000-100000, the molecular weight of polylactic acid has little effect on the release rate, especially within the preferred range), is dissolved in an organic solvent (the organic solvent includes 1,4-dioxane, acetone, chloroform / ethanol mixed solvent, dichloromethane, tetrahydrofuran, and the mixed solvent of the above-mentioned solvents), the concentration is 0.1-10wt%, and the poly Lactic acid film as outer seal;

[0052] (2) Chitosan (mass average molecular weight is 5000-1000000, preferably 5000-100000) with a certain molecular weight is dissolved in an acidic aqueous solution (the acid adopted includes hydrochloric acid, acetic acid, nitric acid), and the obtained concentration is 0.1-10% ( mass fraction) of chitosan solution; methods such as spin coating and drip coating are used to p...

Embodiment 1

[0063] (1) dissolving polylactic acid with a mass average molecular weight of 100,000 in tetrahydrofuran, an organic solvent, at a concentration of 2 wt%, and preparing a polylactic acid film by spin coating as the outer sealing layer;

[0064] (2) 1 g of chitosan with a mass average molecular weight of 500,000 was added to 50 ml of acetic acid solution with a mass fraction of 2%, and magnetically stirred overnight to prepare a chitosan solution with a concentration of 20 mg / ml for use. 0.018g of genipin was dissolved in 3ml of alcohol-water mixture (alcohol:water=3:7 volume ratio) to prepare a genipin solution. Get 10ml chitosan solution and genipin solution and join in the beaker, make it fully mix in magnetic stirring 60min. Then, pour the mixed solution into a plastic petri dish, first cross-link at room temperature for 24 hours, and then freeze-dry to obtain a chitosan film, which is used as an inner controlled release layer and a stem cell scaffold;

[0065] (3) the ste...

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Abstract

The invention provides a preparation method of a sandwich-type composite film stent. A polylactic acid / bioactive glass / chitosan sandwich-type composite film carrier loaded with bioactive factors is created. The preparation method includes 1), preparing a polylactic acid film, mesoporous bioactive glass loaded with the bioactive factors and a chitosan film loaded with seed cells as an outer sealinglayer, a sandwich layer and an inner controlled release and stem cell stent layer respectively; 2), coating the polylactic acid film with the sandwich layer of the bioactive glass loaded with the bioactive factors, and loading the bioactive glass layer with the chitosan film loaded with the seed cells to create the sandwich-type composite film carrier. The preparation method has the advantages that the problem of incapability of repairing and treating single nerve tracts impaired (but not died yet) in the prior art can be solved; the problems that oriented release of drugs cannot be realizedand high concentration of impaired local factors cannot be guaranteed by existing drug delivery systems are also solved.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a preparation method of a sandwich type composite membrane support. Background technique [0002] Spinal cord injury (SCI) is the damage of the spinal cord or cauda equina to varying degrees in the spinal canal caused by various reasons. It is mainly caused by traffic injuries and violent injuries. It not only directly causes the loss of movement and working ability and sensory impairment of patients, but also causes the corresponding respiratory, urinary, digestive system and other organ dysfunction due to the damage of the central nervous system below the injury level. [0003] In addition to the extremely weak regeneration of nerve cells, the reasons that affect the recovery of spinal cord function after spinal cord injury include the following aspects, such as: the lack of neurotrophic factors in the injured area, the formation of glial scars, and the formation of o...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/54A61L27/18A61L27/10A61L27/20A61L27/38A61L27/50
CPCA61L27/54A61L27/10A61L27/18A61L27/20A61L27/3834A61L27/50A61L2300/414A61L2300/602A61L2430/32C08L67/04C08L5/08
Inventor 顾军冯晓军宋晓丽范健徐林张栋纪立军
Owner 无锡市锡山人民医院
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