Controllable slow-release green gel based on alkyl polyglycoside, and preparation method and application of gel

Abstract

The invention relates to a controllable slow-release green gel based on alkyl polyglycoside, and a preparation method and application of the gel. According to the gel, a natural high-molecular polysaccharide derivative is used as a framework; an alkyl polyglycoside (APG) microemulsion is coated with a gridding of a natural high-molecular polysaccharide derivative; the natural high-molecular polysaccharide derivative is obtained by in-situ release and cross-linking of a natural high-molecular material under the action of a hydrogen ion releasing agent and a calcium source; and the APG microemulsion comprises an oil phase, a water phase and a surfactant. According to the invention, the specific microemulsion is carried in the gel system, and a hydrophobic drug is solubilized in the microemulsion, so that the defect that hydrophobic drugs are not easy to carry is avoided. The microemulsion is constructed by using the green surfactant which can be completely degraded, so that the drug carrying quantity of the system can be increased, and the environment friendliness and the biological compatibility are also increased. Through the formed gel system, the slow release of the drug in a controllable period can be realized through the adjustment of the raw material proportion.

Description

technical field [0001] The invention relates to a controllable slow-release green gel based on alkyl polyglucoside and its preparation method and application, belonging to the fields of soft matter science and medicinal chemistry. Background technique [0002] The sustained-release drug carrier can allow the drug to slowly enter a specific site, reduce the drug concentration at a specific site, avoid problems such as excessive local drug concentration and short effective drug concentration maintenance time, and prepare a sustained-release carrier that can controllably release the target drug It is very important in the fields of daily chemistry and medicinal chemistry. [0003] At present, the sustained release of drugs at specific sites by forming hydrogels as drug sustained release carriers has attracted great attention. Hydrogel is a new type of drug delivery carrier with a hydrophilic group, which can be swelled by water but insoluble in water and has a three-dimensiona...

AI Technical Summary

Problems solved by technology

[0004] Most of the existing hydrogel drug sustained-release systems use the swelling effect to load the drug. The swelling effect of the drug loading easily leads to uneven distribution of the drug in the gel, and the drug is easy to leave the gel body in the external environment, resulting in the gel The controlled release effect is poor, and there is no adjustable sustained release period; and the amount of drug carried is limited, which cannot well meet the application requirements

In addition, although biocompatible natural polymers are used as the main raw materials for the preparation of hydrogels, the crosslinking agents used in some systems are not ideal in terms of biocompatibility and environmental friendliness.

[0005] Therefore, due to the limitations of preparation principles, implementation methods, and raw materials used, the existing hydrogel systems have certain deficiencies in terms of biocompatibility, environmental friendliness, uniformity of loaded drugs, and controllable slow-release performance. , hindering the application of the gel system in the controlled release of drugs

Especially because many new medical entity drugs developed in recent years have a certain degree of hydrophobicity, the dispersibility and solubility of such hydrophobic drugs in hydrogel systems are poor, and they are subject to greater controllable and sustained release characteristics. limits

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