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A combination drug for the treatment of diabetic refractory wound complications

A technology for diabetes and complications, applied in the field of drug therapy, can solve the problems of low effective concentration, low effective dose, research and application that have not been reported, and achieve the effects of accelerating the effect and speed, increasing the effective absorption amount, and significant curative effect

Active Publication Date: 2020-07-28
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its research and application in diabetic wound repair has not been reported yet.
At the same time, due to the characteristics of 20(R)-ginsenoside Rg3 itself, which is easy to oxidize, the currently commercially available 20(R)-ginsenoside Rg3 oral preparations all have low effective doses reaching the gastrointestinal tract after taking them, and the effective concentrations in the blood are extremely high. Low case, unsatisfactory efficacy

Method used

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  • A combination drug for the treatment of diabetic refractory wound complications
  • A combination drug for the treatment of diabetic refractory wound complications

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] One, the preparation method of oral preparation of the present invention is as follows.

[0028] (1) By weight, the prescription is: 25% chemically pure 20 (R)-ginsenoside Rg3, 1% binder, 10-30% microcrystalline cellulose, 5-10% micronized silica gel , 0.01-0.05% antioxidant, 1-5% lubricant, 3-15% isolation layer material, 10-40% enteric layer material.

[0029] Wherein, binding agent is hydroxypropyl cellulose; Antioxidant can be one or more mixtures in commonly used drug antioxidants such as citric acid, sodium sulfite, cysteine; Lubricant can be talcum powder, stearic acid One or more mixtures of magnesium and polyethylene glycol, the material of the isolation layer can be one or more mixtures of commonly used drug isolation layer materials such as PEG6000 and hydroxypropyl methylcellulose; the material of the enteric layer can be One or a combination of acrylic resin II, acrylic resin III, hydroxypropyl methylcellulose phthalate, polyvinyl alcohol acetate phthalate...

Embodiment 1

[0049] Embodiment 1: Preparation of oral preparations and topical preparations

[0050] For the convenience of operation, the oral preparations and external application preparations used in the present invention are the formulations of this example. The inventors have found in practice that under the condition of satisfying the dosage of 20(R)-ginsenoside Rg3, the weight gain of the isolation layer and the weight gain of the enteric layer, other equivalent substitute materials within the range of pharmaceutical use, and other equivalent materials can be used. The preparation equipment or method of effective replacement has little effect on the final curative effect.

[0051] (1) Oral preparations: prepared using the above-mentioned preparation method for oral preparations, wherein, by weight, the prescription is: 25% of chemically pure 20(R)-ginsenoside Rg3, 1% of hydroxypropyl cellulose, 25% of Microcrystalline cellulose, 10% micropowder silica gel, 0.03% sodium sulfite, 3% ...

Embodiment 2

[0055] (1) Basic information of the patient: Tang, female, 45 years old, 55kg, with a history of diabetes for 3 years, and the course of diabetic skin refractory wounds was 12 days. There was one wound on the dorsum of the foot, with an area of ​​3cm×5cm. Cause of wound: fall. There was no specific treatment for the wound in the early stage. Bacterial culture of patient's wound secretion, see Proteus, Pseudomonas aeruginosa and Escherichia coli etc.

[0056] (2) Treatment plan.

[0057] Using the oral preparations and external preparations prepared in Example 1, the specific treatment scheme and effects are shown in Table 1.

[0058] Table 1 Treatment plan and effect

[0059] Healing period internal medicine topical medicine Wound condition day 0 / / Wound ulceration, relatively superficial Day 1 1 capsule / time*3 times Dressing change 1 time Non-exudative wound day 5 1 capsule / time*3 times Dressing change 1 time The wound surfa...

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Abstract

The invention belongs to the field of medicine treatment, and in particular relates to a combined medicine for treating refractory wound complications of diabetes. Specifically, the combined medicinecomprises a 20(R)-ginsenoside Rg3 oral preparation and a 20(R)- ginsenoside Rg3 external application preparation, and the invention further provides an application method in the diabetic complicationsof the two preparations. For the first time, the technical scheme proposes that 20(R)-ginsenoside Rg3 has the obvious curative effects for the diabetic complications of the human body; by controllingthe weight of coating materials of the oral preparation, the dissolved amount of 20(R)-ginsenoside Rg3 in the oral cavity, the stomach and the intestines is effectively controlled, and the effectiveabsorbing amount of the human body for the medicines is improved; through the external application preparation, the active ingredients directly act to the wounds caused by diabetes, and thus the healing effect and speed of the wounds are obviously improved.

Description

technical field [0001] The invention belongs to the field of drug therapy, and in particular relates to a combined drug for treating diabetic refractory wound complications. Background technique [0002] Diabetes mellitus (DM) is a series of metabolic disorder syndromes of sugar, protein, fat, water and electrolytes caused by a variety of pathogenic factors acting on the body, leading to hypofunction of pancreatic islets and insulin resistance. Blood sugar is the basic biochemical characteristic. The greatest threat to diabetic patients comes from complications, such as retinopathy, diabetic nephropathy, neuropathy, and refractory wounds, etc., and its treatment is a particularly important link in diabetes treatment. [0003] As the disease progresses, among many complications, spontaneous skin damage in diabetes (such as diabetic ulcers, diabetic blisters, etc.) or refractory skin wounds caused by exogenous trauma has become one of the most common serious complications in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/06A61K9/28A61K47/32A61K47/38A61P17/02
CPCA61K9/0014A61K9/06A61K9/2833A61K31/704A61K47/32A61K47/38A61P17/02
Inventor 李静平柯瑾倪艺榕起荣林
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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