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Traditional Chinese medicine composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of pharmacy, can solve the problems such as inability to block PM2.5, no satisfactory effect, ozone harming human health and the like

Inactive Publication Date: 2018-09-14
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Products currently on the market that claim to prevent or alleviate lung damage caused by inhalable particulate matter have not achieved satisfactory results
Studies have shown that some anti-haze masks on the market can't block PM2.5 at all; indoor air purifiers will absorb some particles, but the ozone they produce seriously endangers human health

Method used

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  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0060] According to some embodiments of the present invention, the present invention also provides a preparation method of a traditional Chinese medicine composition, the specific steps are as follows: heat and reflux extract orange red, Atractylodes macrocephala, mulberry leaves, white hyacinth bean, Polygonatum odoratum with 10 times the amount of distilled water respectively, Filtrate for 2 hours each time, combine the filtrates, concentrate under reduced pressure at 50-60°C, and then freeze-dry to obtain the extracts of the five traditional Chinese medicines; The product and the Polygonatum odoratum extract were weighed and mixed according to the mass ratio of 1:2:4:8:32 to obtain a powdered traditional Chinese medicine composition.

[0061] The test material used in the present invention and its source are as follows:

[0062] 1. Chinese medicinal materials: 105 kinds of traditional Chinese medicines were purchased from Beijing Sanhe Pharmaceutical Co., Ltd.

[0063] 2. ...

Embodiment 1

[0069] The characterization of embodiment 1 inhalable particulate matter

[0070] Use a particle size analyzer to analyze the particle size of the particles used and obtain their particle size distribution, analyze the elements and their content in the sample by inductively coupled plasma mass spectrometry (ICP-MS) atomic emission spectrometry, and use X-ray diffraction to analyze the elements in the sample Compounds and their contents, see the results Figure 1.1 , Tables 1 and 2, where, Figure 1.1 shows the particle size distribution of the particles used, although the present invention uses Figure 1.1 However, the present invention is aimed at the lung injury caused by inhalable particulate matter (ie, particulate matter with a particle size below 10 microns (ie PM10)) in the used particulate matter.

[0071] Table 1 Elemental composition and content of particulate matter

[0072]

[0073] Table 2 Compound composition and content of particulate matter

[0074]

Embodiment 2

[0075] Example 2 Establishment of PM-induced damage to alveolar epithelial A549 cells—a model of oxidative stress, inflammation and apoptosis

[0076] 1. Establish PM-induced oxidative stress and inflammation model in A549 cells

[0077] Use 1640 medium to dilute the PM stock solution into 400μg / ml, 200μg / ml, 100μg / ml, 50μg / ml and 25μg / ml PM suspensions to act on A549 cells for 6h, 12h, 24h and 48h respectively. Oxide dismutase (SOD) content and interleukin 6 (IL-6) content in the cell culture medium, and the cell survival rate was measured by the MTT method, and the ratio of the SOD content to the cell survival rate was used as an index to evaluate the different concentrations of PM. The effect of time on the oxidative stress state of A549 cells; the ratio of IL-6 content to cell survival rate was used as an index to evaluate the effect of different concentrations of PM on the inflammatory state of A549 cells at different times.

[0078] see results Figure 2.1a and 2.1b ....

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Abstract

The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from two or a combination of more of the following raw materials: rhizoma dioscoreae, arillus longan, folium mori, exocarpium citri rubrum, rhizoma polygonati odorati, bulbus fritillariae cirrhosae, bighead atractylodes rhizome, semen lablab album and lotus leaf. The invention also provides a pharmaceutical preparation containing the traditional Chinese medicine composition, and application of the traditional Chinese medicine composition in preparation of the pharmaceutical preparation for preventing or relieving lung injury caused by inhalable particles. The traditional Chinese medicine composition provided by the invention increases the contents of superoxide dismutase and glutathione peroxidase by reducing the accumulation of active oxygen, malondialdehyde, interleukin 6, interleukin-8 and a tumor necrosis factor, thereby improving the anti-oxidation and anti-inflammatory abilities of a human body, enhancing the body immunity and further achieving the purpose of resisting the damage, caused by the inhalable particles, to the human body.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a traditional Chinese medicine composition and its application. Background technique [0002] The impact of air pollution on human health has become a social issue of general concern. According to the statistics of experts from the Chinese Academy of Environmental Sciences, more than 2,000 studies have pointed out that among the inhalable particles, the most harmful to human health is the fine particulate matter (PM2.5) whose diameter is less than or equal to 2.5 microns. PM2.5 has the characteristics of small particle size, long residence time in the body, difficult metabolism, and high content of toxic substances. As a kind of inhalable particulate matter, PM2.5 can enter the human lungs through the respiratory system and settle in the bronchi and alveoli. The finer components can even penetrate the alveoli, interfere with the gas exchange in the lungs, and cause oxidative stress in lu...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K36/8945A61K36/77A61K36/605A61K36/752A61K36/8966A61K36/284A61K36/48A61K36/62A61P11/00
CPCA61K36/284A61K36/48A61K36/605A61K36/62A61K36/752A61K36/77A61K36/8945A61K36/8966A61K36/8969A61P11/00A61K2300/00
Inventor 饶子和张博冯金磊李金楠杨诚
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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