Method for synthesizing intermediate N-[2-(2-hydroxyethyl)ethylsulfonyl]-4-nitrobenzenesulfonamide

Abstract

The invention discloses a method for synthesizing an intermediate N-[2-(2-hydroxyethyl)ethylsulfonyl]-4-nitrobenzenesulfonamide. 4-nitrobenzenesulfonyl chloride, 2-amino-2-hydroxydiethyl sulfide, hydrogen peroxide, tungstic acid, titanium isopropoxide, glacial acetic acid and urea are used as main raw materials. The synthesis method comprises the following steps: the 4-nitrobenzenesulfonyl chloride, 2-amino-2-hydroxydiethyl sulfide undergo an amidation reaction under the action of a catalyst, and the obtained reaction product is oxidized by the hydrogen peroxide to obtain the intermediate product. The surface of the catalyst is negatively charged, so reactant molecules undergo a hydrolysis reaction, and the isomerization reaction is reduced, thereby the yield of the product is obviously improved.

Description

technical field [0001] The invention relates to a method for synthesizing an intermediate N-[2-(2-hydroxyethyl)ethylsulfonyl]-4-nitrobenzenesulfonamide, which belongs to the field of chemical synthesis. Background technique [0002] At present, the annual output of reactive dyes in the world accounts for about 20% of the total output of dyes. Reactive dyes have the advantages of wide color spectrum, bright color, excellent performance, and strong applicability, especially as one of the best choices to replace banned dyes and other dyes for cellulose fibers such as ice dyes, sulfur dyes and vat dyes. Reactive dyes It has become the most important class of dyes for cellulose fibers and some synthetic fibers. Existing reactive dyes still have problems such as low dye utilization rate, large amount of inorganic salt used in dyeing, a large amount of colored sewage produced in the synthesis of intermediates and their dyes, low yield of dye intermediates, etc., which cause some w...

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Problems solved by technology

Existing reactive dyes still have problems such as low dye utilization rate, large amount of inorganic salt used in dyeing, a large amount of colored sewage produced in the synthesis of intermediates and their dyes, low yield of dye intermediates, etc., which cause some waste of resources and industrial pollution. , Therefore, the molecular structure of reactive dye intermediates with appropriate carbon chain lengths was synthesized, the dye structures were arranged more regularly, the intermediates with good reactivity with fibers and high color fixation rate, and better unit reactions were explored. It is of great significance to improve the yield of intermediates and shorten the reaction time by ordering and optimizing the process conditions of each step of reaction.

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