Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of 3D-printable agar/polyacrylamide double hydrogen bond synergistic cross-linked high-toughness hydrogel

A polyacrylamide and 3D printing technology, applied in the direction of additive processing, etc., can solve the problems of hydrogel preparation and molding process limitations, inability to apply hydrogel, and difficult synthesis control, etc., to achieve short preparation cycle, ensure uniformity, The effect of low production cost

Active Publication Date: 2021-02-02
HUBEI UNIV OF TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the introduced hydrophobic association, it is difficult to separate the hydrophilic phase and the lipophilic phase, relying on high-speed stirring, the synthesis is difficult to control, and the preparation and molding process of the hydrogel is greatly limited. Free-form methods that do not affect the biocompatibility of the hydrogel are not suitable for this type of hydrogel
Therefore, the application of this hydrogel in the fields of tissue engineering, drug screening, and organs on a chip is limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of 3D-printable agar/polyacrylamide double hydrogen bond synergistic cross-linked high-toughness hydrogel
  • Preparation method of 3D-printable agar/polyacrylamide double hydrogen bond synergistic cross-linked high-toughness hydrogel
  • Preparation method of 3D-printable agar/polyacrylamide double hydrogen bond synergistic cross-linked high-toughness hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Step 1): Weigh 0.2g of agar (Agar) into 8mL of deionized water, stir at 75°C and 500RPM for 20min at high speed to dissolve to obtain a transparent aqueous solution.

[0034]Step 2): Weigh 3.554g AM and 0.0074g KA respectively, add to 2mL and stir to dissolve to obtain a uniform transparent aqueous solution. Stir this solution in the solution of step 1) at 50°C and 500RPM for 5 minutes in a dark environment to prepare a mixed solution with 0.06536 mol / L Agar, 5 mol / L AM and 0.005 mol / L KA.

[0035] Step 3): Inject the mixed solution obtained in step 2) into a glass mold under light-shielding conditions, and place the glass mold under ultraviolet light for 5-7 hours to obtain a strong double hydrogen bond synergistically cross-linked and high-toughness Agar / PAM Hydrogels.

[0036] Experiments show that the tensile strength of the double hydrogen bond synergistically cross-linked Agar / PAM hydrogel material obtained in this example is 0.449 MPa, and the elongation at brea...

Embodiment 2

[0038] Step 1): Weigh 0.2g of agar (Agar) into 8mL of deionized water, stir at 75°C and 500RPM for 20min at high speed to dissolve to obtain a transparent aqueous solution.

[0039] Step 2): Weigh 4.9756g AM and 0.0103g KA respectively, add to 2mL and stir to dissolve to obtain a uniform transparent aqueous solution. Stir this solution in the solution of step 1) at 50°C and 500RPM for 5min in a light-proof environment to prepare a mixed solution with 0.06536 mol / L of Agar, 7 mol / L of AM and 0.007 mol / L of KA.

[0040] Step 3): Inject the mixed solution obtained in step 2) into a glass mold under light-shielding conditions, and place the glass mold under ultraviolet light for 5-7 hours to obtain a strong double hydrogen bond synergistically cross-linked and high-toughness Agar / PAM Hydrogels.

[0041] Experiments show that the tensile strength of the double hydrogen bond synergistically cross-linked Agar / PAM hydrogel material obtained in this example is 0.490 MPa, and the elong...

Embodiment 3

[0043] Step 1): Weigh 0.2g of agar (Agar) into 8mL of deionized water, stir at 75°C and 500RPM for 20min at high speed to dissolve to obtain a transparent aqueous solution.

[0044] Step 2): Weigh 6.3972g AM and 0.0132g KA respectively, add to 2mL and stir to dissolve to obtain a uniform transparent aqueous solution. Stir this solution in the solution of step 1) at 50°C and 500RPM for 5min in a light-proof environment to prepare a mixed solution with 0.06536mol / L Agar, 9mol / L AM and 0.009mol / L KA.

[0045] Step 3): Inject the mixed solution obtained in step 2) into a glass mold under light-shielding conditions, and place the glass mold under ultraviolet light for 5-7 hours to obtain a strong double hydrogen bond synergistically cross-linked and high-toughness Agar / PAM Hydrogels.

[0046] Experiments show that the double hydrogen bond synergistically cross-linked Agar / PAM hydrogel material obtained in this example has a tensile strength of 0.500 MPa and an elongation at break ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
tensile strengthaaaaaaaaaa
tensile strengthaaaaaaaaaa
tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of agar / polyacrylamide double hydrogen bond synergistically cross-linked high-toughness hydrogel which can be used for 3D printing. First, the agar is dissolved in deionized water under heating and stirring conditions to obtain a uniform aqueous solution, and then the mixed solution of acrylamide and photoinitiator dissolved in deionized water is added to the aqueous solution of agar and mixed evenly, and the final mixed solution is used in a mold or The method of 3D printing is preformed. First, the agar is crosslinked at low temperature, and then the acrylamide is polymerized and hydrogen bonded and crosslinked under ultraviolet light, forming a high-toughness hydrogel with double hydrogen bonds and synergistic crosslinking; due to the hydrogel The gel contains natural polymer agar, and in the sol state, the viscosity is regulated by adding a small amount of fumed silica. It has good anti-collapse and rapid gelation characteristics, and can realize 3D printing.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for preparing a 3D-printable agar / polyacrylamide double hydrogen bond synergistically cross-linked high-toughness hydrogel. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network structure of high water content and high porosity formed by chemical cross-linking or physical cross-linking. This characteristic is similar to that of biological soft tissue, which makes hydrogel widely used in the field of tissue engineering. potential application. Due to the high water content of hydrogels, their mechanical properties are generally poor, and chemically crosslinked hydrogels have poor tissue compatibility, which cannot meet the requirements of use. The current chemically cross-linked hydrogels still have the disadvantages of being difficult to repair after cross-linking damage and poor tissue compatibility, so the r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L33/26C08L5/12C08F120/56C08F2/48C08K3/36B33Y70/10
CPCB33Y70/00C08F2/48C08F120/56C08J3/075C08J2333/26C08J2405/12C08K3/36
Inventor 李学锋王慧张高文龙世军舒萌萌张奕坤邱迪
Owner HUBEI UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com