Compounds capable of preventing anxiety, and preparation method thereof

Abstract

The invention relates to compounds capable of preventing anxiety, and a preparation method thereof. The preparation method comprises following steps: 1, medicinal material herb or fruits are subjectedto selection so as to obtain herb dried samples or dried fruits, and smashing is carried out so as to obtain a medicinal material powder; 2, the medicinal material powder is subjected to heating extraction; 3, an obtained extracted solution is subjected to grinding using a colloid mill so as to obtain a colloid extracted solution, and then centrifugation is carried out; 4, filter residue is removed, and extracted components are collected; 5, an obtained extracted product is subjected to treatment using a micro-reticular resin and a silicagel column, and two-dimensional reversion-phase / hydrophilic chromatography is adopted so as to obtain monomer compounds; and 6, 8 flavonoid compounds capable of preventing anxiety are obtained via screening. No muscle relaxing or depression inducing sideeffect is caused by the 8 flavonoid compounds; the design of the preparation method is scientific and reasonable; the extraction rate and the preparation efficiency are high; the obtained compounds are stable in properties, and high in cost, and possesses excellent anxiety preventing effect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to a compound with anti-anxiety effect and a preparation method thereof. Background technique [0002] The scientific name of snow ganoderma is Gansu flea (Arenaria kansuensis Maxim.), which is a perennial cushion-like herbaceous plant belonging to Caryophyllaceae. Snow Ganoderma lucidum uses the whole herb as medicine. It is bitter and cold in nature and has the effects of clearing away heat and benefiting the lungs, relieving cough, dispelling swelling, lowering blood pressure, clearing stranguria and relieving pain. It is often used in the treatment of jaundice, gonorrhea, uterine disease, pneumonia and various lung diseases. Central Asian aster (Asterothamnus centrali-asiaticus) is a plant of the Asteraceae genus. It mainly grows in grasslands and desert areas at an altitude of 1,300 meters to 3,900 meters. Due to its high nutritional value, it is mainly used as forage gras...

AI Technical Summary

Problems solved by technology

[0006] In recent years, some progress has been made in the research and development of anti-anxiety drugs mediated by GABA-A receptors. Chinese patent CN200980120286 reports a GABA-A receptor modulator triazoloquinazolinone compound, which is effective in mammals. It has anti-anxiety, anti-convulsant, sedative and hypnotic effects; Chinese patent CN201010604032 reports an anti-anxiety drug and its preparation method, which involves the preparation of Rhodiola rosea, Hypericum perforatum, Gastrodia elata, and Rehmannia glutinosa raw materials. Animal experiments show that it can Significantly increased the secretion level of the inhibitory neurotransmitter GABA in the serum and improved the anti-anxiety behavior ability of mice, but did not reveal the material basis of the anti-anxiety effect of the API

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