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Novel application of rhizoma cimicifugae and extract thereof

A technology for extracts and new uses, applied in the field of traditional Chinese medicine and health care products, can solve problems such as no direct systematic reports

Active Publication Date: 2018-06-22
HEFEI UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In previous research reports at home and abroad, carnitine has the effects of inhibiting the proliferation of breast cancer cells, anti-HIV, and improving bone hyperplasia. However, there is no direct and systematic report on the effect of carnitine on diet-induced obesity in mice.

Method used

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  • Novel application of rhizoma cimicifugae and extract thereof
  • Novel application of rhizoma cimicifugae and extract thereof
  • Novel application of rhizoma cimicifugae and extract thereof

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Experimental program
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Embodiment Construction

[0031] In order to better understand the essence of the present invention, the experimental results of the effects of Cimicifuga and its extracts on mice fed a high-fat diet will be used to illustrate that it has medicinal value for weight loss and hypoglycemia.

[0032] 1. Research Methods

[0033] 1.1 Experimental animals

[0034] 3-week-old C57BL / 6 male mice were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and were raised in the SPF grade animal room of Hefei University of Technology. They had free access to food and water, and the temperature and humidity of the animal room were maintained at 25°C and 40% respectively. , The light cycle is 12h light / 12h dark.

[0035] 1.2 Experimental drugs

[0036] The low-fat feed formula refers to Research Diets D12450B, 10% of energy comes from fat; the high-fat feed formula refers to Research Diets D12451, 45% of energy comes from fat. 0.15% Cimicifuga rhizome, 0.03% Cimicifuga ethanol extract, 0....

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Abstract

The invention discloses a novel application of rhizoma cimicifugae and an extract thereof. According to the invention, it is discovered that the rhizoma cimicifugae, an alcohol extract of the rhizomacimicifugae and an ethyl acetate phase extract of the rhizoma cimicifugae are obvious in weight losing and blood glucose reducing effects, and weight losing and blood glucose reducing effects of a natural compound, namely actinodaphnine, in the ethyl acetate phase extract of the rhizoma cimicifugae are confirmed. The actinodaphnine is a 9,19-cycloartane triterpenoid saponin compound. Based upon animal experiments, it is proved that the actinodaphnine can prevent the formation of obesity induced by high fat diets, and moreover, the actinodaphnine can treat the formed obesity induced by high fatdiets and can improve obesity-related sugar intolerance, insulin resistance and hepatic injury. The rhizoma cimicifugae, the alcohol extract of the rhizoma cimicifugae, the ethyl acetate phase extract of the rhizoma cimicifugae and the actinodaphnine can be used for preparing medicines or health-care products for losing weight, reducing blood glucose and protecting liver.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines and health care products, and in particular relates to the weight-loss and hypoglycemic effects of Cimicifuga, the alcohol extract of Cimicifuga, the ethyl acetate phase extract of Cimicifuga and the natural compound carnitine therein. Background technique [0002] Overweight and obesity have become a global health problem with a rapidly increasing trend. High-calorie diets and a sedentary lifestyle are believed to be the main reasons for the increased prevalence of obesity. Obesity-related metabolic diseases such as insulin resistance, diabetes, atherosclerosis and dyslipidemia have increasingly become important factors that endanger human health, but currently there is a lack of chemically synthesized drugs with clear efficacy and low side effects. Therefore, understanding the formation mechanism of obesity and related metabolic diseases and finding natural anti-obesity ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P3/04A61P3/06A61P3/10A61P5/50A61P1/16A23L33/105
CPCA23L33/105A23V2200/00A61K31/7048A23V2200/328A23V2200/332A23V2250/21
Inventor 刘健邱明华袁静静年寅汪璐史强强
Owner HEFEI UNIV OF TECH
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