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A kind of injectable continuous antibacterial and anti-inflammatory bone cement and preparation method thereof

An antibacterial, anti-inflammatory, and bone cement technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of antibiotic side effects, poisoning, etc.

Inactive Publication Date: 2020-07-07
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics usually have strong toxic and side effects. If used in large doses throughout the body, they will cause toxic effects on internal organs such as liver and kidney.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of tetrapod zinc oxide: Take 5g of zinc powder and add it to a hydrogen peroxide solution with a concentration of 15wt%, stir for 30 minutes, then put it into an ultrasonic generator and sonicate for 1 hour, so that the zinc powder can fully contact and react with hydrogen peroxide, and let it stand for 15 hours. Filtrate, dry, and then put into a tube furnace with a preheating temperature of 900°C for calcination for 5 minutes to obtain tetrapod-like zinc oxide.

[0027] Preparation of porous chitosan: Measure 30mL liquid paraffin, 9mL cyclohexane, 3mL ethyl acetate, 0.5mL Span-80, mix them evenly, put them in a constant temperature water bath, heat to 50°C, and stir at a speed of 500rpm for 1h , add 1mL chitosan acetic acid solution subsequently, wherein the massfraction of chitosan is 1%, the massfraction of acetic acid is 2%, after reacting 1h, slowly add 0.5mL mass concentration again and be the glutaraldehyde of 50%, stir After reacting for 4 hours, fi...

Embodiment 2

[0034] The preparation of tetraacicular zinc oxide is the same as in Example 1.

[0035] Preparation of porous chitosan: Measure 30mL liquid paraffin, 9mL cyclohexane, 3mL ethyl acetate, 0.3mL Span-80, mix them evenly, place them in a constant temperature water bath, heat to 50°C, and stir at a speed of 500rpm for 1h , add 1mL chitosan acetic acid solution subsequently, wherein the massfraction of chitosan is 1.5%, the massfraction of acetic acid is 2%, after reacting 1h, slowly add 0.5mL mass concentration again and be the glutaraldehyde of 50%, stir After reacting for 4 hours, filter with suction, wash with petroleum ether, then sequentially extract with petroleum ether and ethanol for 24 hours, and vacuum-dry at 55-60° C. to obtain porous chitosan.

[0036] Preparation of modified β-cyclodextrin: Dissolve β-cyclodextrin by heating in distilled water to prepare a β-cyclodextrin solution with a mass concentration of 10mg / mL. Take 100mL of β-cyclodextrin solution and add 0.2g ...

Embodiment 3

[0042] The preparation of tetraacicular zinc oxide is the same as in Example 1.

[0043] Preparation of porous chitosan: Measure 30mL liquid paraffin, 9mL cyclohexane, 4mL ethyl acetate, 0.5mL Span-80, mix them evenly, put them in a constant temperature water bath, heat to 50°C, and stir at 450rpm for 1h , add 1mL chitosan acetic acid solution subsequently, wherein the massfraction of chitosan is 1%, the massfraction of acetic acid is 2%, after reacting 1h, slowly add 0.5mL mass concentration again and be the glutaraldehyde of 50%, stir After reacting for 5 hours, filter with suction, wash with petroleum ether, then sequentially extract with petroleum ether and ethanol for 24 hours, and vacuum-dry at 55-60° C. to obtain porous chitosan.

[0044] Preparation of modified β-cyclodextrin: Dissolve β-cyclodextrin by heating in distilled water to prepare a β-cyclodextrin solution with a mass concentration of 10mg / mL. Take 100mL of β-cyclodextrin solution and add 0.4g polyethylene gl...

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PUM

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Abstract

The invention relates to the technical field of orthopedics, in particular to injectable continuous antibacterial anti-inflammation bone cement and a preparation method thereof. The injectable continuous antibacterial anti-inflammation bone cement comprises powder and liquid in a mass ratio of 2.0-2.5:1. The powder is prepared from, by weight, 30-38 parts of calcium sulfate, 30-38 parts of nano hydroxyapatite, 5-10 parts of drug-loading composite microspheres and 1-2 parts of sodium hypophosphite, wherein the drug-loading composite microspheres are microcapsule particles with anti-inflammatorydrug as capsule cores and chitosan / beta-cyclodextrin / zinc oxide compound as capsule materials, and zinc oxide refers to tetrapod-like zinc oxide whiskers. Since the bone cement contains the drug-loading composite microspheres with anti-inflammatory drug as capsule cores and the chitosan / beta-cyclodextrin / zinc oxide compound as capsule materials, on the one hand, a slow release effect on anti-inflammatory drugs can be achieved to avoid toxic action caused by large dosage, and on the other hand, a continuous long-acting antibacterial and anti-inflammation purpose is achieved by synergistic effects of chitosan, beta-cyclodextrin and zinc oxide.

Description

technical field [0001] The invention relates to the technical field of orthopedic materials, in particular to an injectable continuous antibacterial and anti-inflammatory bone cement and a preparation method thereof. Background technique [0002] In recent years, bone defects caused by industrial accidents, traffic accidents, orthopedic diseases, etc. have shown a high incidence rate. In addition, my country is currently moving towards an aging society, and the number of orthopedic degenerative diseases related to the elderly population continues to increase, resulting in the demand for orthopedic repair materials. demand is increasing. Bone cement is a bone repair material used in orthopedic surgery. It is a biomaterial used to fill the gap between bone and implant or bone cavity and has self-setting properties. Bone cement fixation can ensure the immediate stability of the prosthesis after replacement, without any micro-movement on the bone tissue-bone cement-prosthesis in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61L27/20A61L27/02A61L27/12A61L27/50A61L27/54A61K47/40A61K47/02A61K31/05A61K31/045A61K31/58
CPCA61K9/501A61K9/5036A61K31/045A61K31/05A61K31/58A61L27/025A61L27/12A61L27/20A61L27/222A61L27/50A61L27/54A61L2300/216A61L2300/404A61L2300/41A61L2300/602A61L2400/06C08L5/08C08L5/16
Inventor 徐海涛
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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