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Preparation method of metal phase tungsten oxide and application of metal phase tungsten oxide

A phase tungsten oxide, metal technology, applied in the field of preparation technology and the application of photothermal therapy of biological cancer, can solve problems such as physiological toxicity, nanomaterial limitation, etc., to achieve enhanced absorption range and intensity, efficient photothermal conversion, and superior biological safety. sexual effect

Active Publication Date: 2022-03-25
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, how to prepare nanomedicines with efficient targeting to the tumor microenvironment without causing toxicity to surrounding normal tissues remains a great challenge.
The accumulation of nanomaterials in the body may lead to the risk of physiological toxicity, which may limit the application of nanomaterials in further biomedical clinical applications

Method used

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  • Preparation method of metal phase tungsten oxide and application of metal phase tungsten oxide
  • Preparation method of metal phase tungsten oxide and application of metal phase tungsten oxide
  • Preparation method of metal phase tungsten oxide and application of metal phase tungsten oxide

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preparation example Construction

[0038] Based on the above exploration, this application aims at the practical technical problems existing in the preparation and photothermal anti-cancer application of existing tungsten oxide near-infrared conversion materials. The lithiation treatment method of light-to-heat conversion ability, specifically, the embodiment of the present invention discloses a preparation method of metal-phase tungsten oxide, including the following steps:

[0039] A) carrying out solvothermal reaction of polyethyleneimine, tungsten source and water to obtain precipitation;

[0040] B) Calcining the precipitate after drying to obtain WO 3 powder;

[0041] C) the WO 3 The powder is mixed with metal powder and then mixed with lithium salt solution to react to obtain Li-WO 3 ; The metal powder is selected from zinc powder, copper powder, magnesium powder or aluminum powder.

[0042] In the process of preparing metal-phase tungsten oxide, the polyethyleneimine, tungsten source and water under...

Embodiment 1

[0054] Weigh 0.3g of polyethyleneimine (molecular weight 10000), dissolve it in 15mL deionized water, then add 15mL concentration of 3M aqueous hydrochloric acid, then stir for 30 minutes, then add 30mL concentration of 0.3M Na to the above solution 2 WO 4 Solution, continue to stir for half an hour; finally, transfer the above mixed solution to a hydrothermal reaction kettle with a volume of 100mL, put it in a high-temperature oven, heat to 170°C and keep it warm for 12 hours;

[0055]After the hydrothermal reaction is completed and naturally cooled to room temperature, transfer the precipitate and solution in the hydrothermal reaction kettle to a centrifuge tube, centrifuge at a speed of 11,000 rpm for 3 minutes, wash with ethanol and deionized water three times, and dry in vacuum after centrifugation The oven was dried at 60°C to obtain powder, and the dried powder was placed in a ceramic crucible, and calcined in a muffle furnace in air at 500°C and kept for 4 hours to obt...

Embodiment 2

[0075] Weigh 0.35g of polyethyleneimine (molecular weight 20000), dissolve it in 15mL deionized water, then add 20mL concentration of 2.5M hydrochloric acid aqueous solution, then stir for 30 minutes, then add 30mL concentration of 0.28M hydrochloric acid to the above solution Na 2 WO 4 Solution, continue to stir for half an hour, and finally, transfer the above mixed solution to a hydrothermal reaction kettle with a volume of 100mL, put it in a high-temperature oven, heat to 160°C and keep it warm for 15 hours;

[0076] After the hydrothermal reaction is completed and naturally cooled to room temperature, transfer the precipitate and solution in the hydrothermal reaction kettle to a centrifuge tube, centrifuge at a speed of 10,000 rpm for 5 minutes, wash with ethanol and deionized water three times, and dry in vacuum after centrifugation The oven was dried at 60°C to obtain powder, and the dried powder was placed in a ceramic crucible, and calcined in a muffle furnace in air...

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Abstract

The invention provides a preparation method of metal phase tungsten oxide, which comprises the following steps: A) carrying out hydrothermal reaction on polyethyleneimine, a tungsten source and water to obtain a precipitate; b) drying the precipitate, and calcining to obtain WO3 powder; and C) mixing the WO3 powder with metal powder, then mixing with a lithium salt solution, and reacting to obtain Li-WO3. In the preparation process of the metal phase tungsten oxide, lithium ions are introduced into WO3 crystal lattices, so that the concentration of free electrons in the material is increased, finally, the phase transformation process from an insulating phase to a metal phase is induced, and Li-WO3 energy band gaps after lithiation disappear, so that the response range of the material to infrared light can be widened; the near-infrared photothermal performance of the material is improved.

Description

technical field [0001] The invention relates to the preparation technology of photothermal conversion materials and the application field of photothermal therapy of biological cancer, in particular to a preparation method of metal-phase tungsten oxide and the application of metal-phase tungsten oxide. Background technique [0002] The rapid development of nanobiotechnology has produced many therapeutic strategies to combat the pathological abnormalities of cancer. Combining advanced manufacturing processes and engineering methods, various nanomedicine-based therapeutic platforms have achieved certain therapeutic effects. For example, the rapid development of nanomedical technology provides a variety of novel diagnostic methods for tumor treatment, in which non-invasive and energy-triggered technologies (such as ultrasound, X-rays, alternating magnetic fields, and infrared light) are used in vitro to effectively Tumor eradication is considered to be one of the most promising ...

Claims

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Application Information

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IPC IPC(8): C01G41/02A61K41/00A61P35/00
CPCC01G41/02A61K41/0052A61P35/00C01P2004/80C01P2004/03C01P2002/72
Inventor 江俊王育才朱青蒋为
Owner UNIV OF SCI & TECH OF CHINA
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