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Continuous photoinduction micro-droplet generation and transfer method based on polymethyl methacrylate and C-cut lithium niobate crystal interlayer chip

A technology for cutting lithium niobate and micro-droplets, which is applied in the field of microfluidics, can solve the problems of large influence on the stability of micro-droplets, the inability to continuously generate micro-droplets, complex chip structures, etc., achieve short contact time and ensure stability performance, the effect of simple chip structure

Inactive Publication Date: 2018-05-15
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The micro-droplet generation methods reported so far have defects such as inability to continuously generate micro-droplets, great impact on the stability of micro-droplets, complex chip structures, and the need for external drive equipment.

Method used

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  • Continuous photoinduction micro-droplet generation and transfer method based on polymethyl methacrylate and C-cut lithium niobate crystal interlayer chip
  • Continuous photoinduction micro-droplet generation and transfer method based on polymethyl methacrylate and C-cut lithium niobate crystal interlayer chip
  • Continuous photoinduction micro-droplet generation and transfer method based on polymethyl methacrylate and C-cut lithium niobate crystal interlayer chip

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] A laser with a wavelength of 405nm is used, a halogen lamp is used as the background light source, the magnification of the focusing objective lens is 25 times, and the distance between chips is adjusted to 10 μm. Adjust the three-dimensional micro-motion chip translation stage so that the lower surface of the upper substrate of the chip is located near the focal point of the focusing objective lens, turn on the laser, and adjust the focusing laser power to 10mW. Under this configuration, a micro-droplet with a diameter of 90 μm is generated every 5 s, and the transfer speed of the micro-droplet is 136 μm / s.

example 2

[0026] A laser with a wavelength of 405nm is used, a white LED light is used as the background light source, the magnification of the focusing objective lens is 25 times, and the distance between chips is adjusted to 12 μm. Adjust the three-dimensional micro-motion chip translation stage so that the lower surface of the upper substrate of the chip is located near the focal point of the focusing objective lens, turn on the laser, and adjust the focusing laser power to 15mW. Under this configuration, a micro-droplet with a diameter of 110 μm is generated every 3 s, and the transfer speed of the micro-droplet is 71.4 μm / s.

example 3

[0028] A laser with a wavelength of 532nm is used, a halogen lamp is selected as the background light source, the magnification of the focusing objective lens is 25 times, and the distance between chips is adjusted to 8 μm. Adjust the three-dimensional micro-motion chip translation stage so that the lower surface of the upper substrate of the chip is located near the focal point of the focusing objective lens, turn on the laser, and adjust the focusing laser power to 20mW. Under this configuration, a droplet with a diameter of 100 μm is generated every 0.6 s, and the transfer speed of the droplet is 180.5 μm / s.

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Abstract

The invention discloses a continuous generation and synchronous transfer method of micro-droplets. According to the method, polymethyl methacrylate (PMMA) as a lower substrate and a +C surface of a C-cut lithium niobate crystal as an upper substrate oppositely form a chip in a sandwich structure, and the chip is simple and reliable in structure. The chip in the sandwich structure is irradiated byaggregated laser light; the micro-droplets are generated via a dielectrophoretic force by using a photovoltaic effect of the lithium niobate crystal; the generated micro-droplet are driven to be transferred by a thermal expansion effect of PMMA at the same time; and continuous generation and synchronous transfer of the micro-droplets are accomplished under the condition of continuous irradiation.The method comprehensively utilizes the photovoltaic effect of the lithium niobate crystal and the thermal expansion effect of PMMA; the micro-droplets move in a direction opposite to the aggregated laser light after the generation; the aggregated laser light has short action time on the micro-droplets; and the stability of the micro-droplets can be effectively ensured. The technology can be usedfor preparation of micro agents and fluid samples in biological, chemical and medical analysis processes, and has very important significance for development of fields of biomedical care, medicine diagnosis, environmental monitoring, molecular biology and the like.

Description

technical field [0001] The invention relates to a microfluidic technology, in particular to a method capable of continuously generating and synchronously transferring microdroplets. Background technique [0002] Microfluidic technology is usually used in the separation and transportation of micro-medicine and fluid samples in the process of biological, chemical and medical analysis. Among them, micro-droplet generation technology is a basic and important technology in the field of microfluidics. The development of this technology is of great significance to the development of biomedicine, drug diagnosis, food hygiene, environmental monitoring, and molecular biology. . [0003] In 2013, Ye Jiaming announced a microfluidic chip for producing multi-component micro-droplets (patent application number: 201310341698.9). This chip consists of sample solution inlet and channel, concentration gradient generation unit, water phase inlet, oil It is composed of a phase introduction in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N21/63
CPCB01L3/502792G01N21/63
Inventor 樊博麟阎文博李菲菲陈洪建昝知韬李少北王旭亮
Owner HEBEI UNIV OF TECH
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