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Dual imaging guided photo-thermal therapy multifunctional nano hybrid and preparation method

A nano-hybrid, imaging-guided technology, applied in the field of medicine, can solve problems such as instability in vivo and in vitro, strong toxicity, and restrictions on the development and use of bismuth selenide, and achieve improved physical stability, low toxicity, and good photothermal stability Effect

Inactive Publication Date: 2018-04-24
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the existing research, the synthesis method of bismuth selenide is highly toxic due to the use of sodium selenate as the selenium source, and the synthesized bismuth selenide is highly oxidized and unstable in vivo and in vitro, which largely limits the selenization. Development and use of bismuth

Method used

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  • Dual imaging guided photo-thermal therapy multifunctional nano hybrid and preparation method
  • Dual imaging guided photo-thermal therapy multifunctional nano hybrid and preparation method
  • Dual imaging guided photo-thermal therapy multifunctional nano hybrid and preparation method

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Embodiment 1

[0034] A method for preparing a dual-imaging-guided photothermal therapy multifunctional nano-hybrid, comprising the following steps:

[0035] (1) Prepare bismuth selenide nanoplate powder by solvent method:

[0036] A. Add selenium powder and sodium borohydride to water at a molar ratio of 1:2:7, react in an ice-water bath under nitrogen protection to obtain a liquid containing selenium and sodium hydride, and seal it;

[0037] B. Dissolve 0.5 g of polyvinylpyrrolidone with an average molecular weight of k13-18 in 20 mL of ethylene glycol and put it into a reaction vessel; another 0.226 g of bismuth nitrate pentahydrate is dissolved in 20 mL of ethylene glycol and add it to the reaction vessel Medium; at room temperature, stir, blow in nitrogen, heat to 160°C, the liquid turns from light yellow to turbid, add 3.5mL of the liquid prepared in step A, react for 10 minutes, and cool down to room temperature; centrifuge at 12000 rpm for 10 minutes, and use Volume concentration is...

Embodiment 2

[0041] A method for preparing a dual-imaging-guided photothermal therapy multifunctional nano-hybrid, comprising the following steps:

[0042] (1) Prepare bismuth selenide nanoplate powder by solvent method:

[0043] A. Add selenium powder and sodium borohydride to water at a molar ratio of 1:2:7, react in an ice-water bath under nitrogen protection to obtain a liquid containing selenium and sodium hydride, and seal it;

[0044] B. Dissolve 0.5 g of polyvinylpyrrolidone with an average molecular weight of k13-18 in 20 mL of ethylene glycol and put it into a reaction vessel; another 0.226 g of bismuth nitrate pentahydrate is dissolved in 30 mL of ethylene glycol and add it to the reaction vessel Medium; at room temperature, stir, blow in nitrogen, heat to 160°C, the liquid turns from light yellow to turbid, add 3mL of the liquid prepared in step A, react for 8 minutes, and cool down to room temperature; centrifuge at 10,000 rpm for 12 minutes, the volume Concentration is that ...

Embodiment 3

[0048] A method for preparing a dual-imaging-guided photothermal therapy multifunctional nano-hybrid, comprising the following steps:

[0049] (1) Prepare bismuth selenide nanoplate powder by solvent method:

[0050] A. Add selenium powder and sodium borohydride to water at a molar ratio of 1:2:7, react in an ice-water bath under nitrogen protection to obtain a liquid containing selenium and sodium hydride, and seal it;

[0051] B. Dissolve 0.5 g of polyvinylpyrrolidone with an average molecular weight of k13-18 in 30 mL of ethylene glycol and put it into a reaction vessel; another 0.226 g of bismuth nitrate pentahydrate is dissolved in 20 mL of ethylene glycol and add it to the reaction vessel Medium; at room temperature, stir, blow in nitrogen, heat to 170°C, the liquid turns from light yellow to cloudy, add 3.5mL of the liquid prepared in step A, react for 12 minutes, and cool down to room temperature; centrifuge at 14000 rpm for 8 minutes, and use for precipitation Volume...

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Abstract

The invention discloses a dual-imaging-guided photothermal therapy multifunctional nano-hybrid and a preparation method. The preparation steps are: (1) preparing bismuth selenide nanoplate powder by solvent method: hyaluronic acid doped polypyrrole coated bismuth selenide Nanoplate: dissolve bismuth selenide nanoplate powder and polyvinylpyrrolidone with an average molecular weight of k13-18 in water, add pyrrole, stir, transfer to ice bath, add ferric chloride aqueous solution drop by drop, add hyaluronic acid Acid aqueous solution, reaction; dialyzed polymer solution, centrifuged, and dried precipitate, that is. The hybrid compound of the present invention has good physical stability, and exhibits good water solubility, biocompatibility, strong near-infrared absorption and good photothermal stability, and can be used for photothermal therapy guided by CT and PA imaging; Good in vivo targeting; simple preparation process, mild reaction conditions, strong reaction controllability, low toxicity, easy scale-up, readily available raw materials, and cheap prices.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a dual-imaging-guided photothermal therapy multifunctional nano-hybrid and a preparation method. Background technique [0002] Diagnosis and therapeutics is a treatment strategy that combines molecular diagnosis and molecular therapy. In recent years, as a new disease treatment strategy, especially in tumor treatment, it has received widespread attention. The treatment mode based on diagnostic therapeutics can realize: ①Visualization of the drug delivery process in vivo; ②Visualization of the distribution and release process of the drug at the target site of administration; ③Diagnosis at the same time as treatment, realizing real-time monitoring of tumor treatment and individualized drug delivery Wait. Therefore, diagnostics and therapeutics are of great significance to the real-time monitoring of therapeutic effect during tumor treatment, timely adjustment of dosage or treatment plan, rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/36A61K47/32A61K49/00A61K49/04A61P35/00
CPCA61K41/0052A61K9/5138A61K9/5161A61K49/00A61K49/0002A61K49/04
Inventor 李楠宋宜霖王金平刘丽孙琪游青程玉王思宇王怡丹
Owner TIANJIN UNIV
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