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Periodontium regeneration and repair membrane and preparation method thereof

A technology for periodontal tissue regeneration and membrane regeneration, applied in the field of biomedical engineering, can solve problems such as limited effect, inability to achieve periodontal tissue regeneration and reconstruction, and failure to form cementum-periodontal ligament interface structure, so as to maintain adhesion ability , Contribute to the effect of repairing regeneration and enhancing mechanical properties

Inactive Publication Date: 2018-03-23
GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of existing treatment techniques is limited. Except for some very narrow subosseous pocket defects or second-degree furcation disease of mandibular molars, ideal results have not been achieved in the treatment of various severe periodontitis. The plasmodium-periodontal ligament interface structure is still unable to form
It can be seen that the simple barrier obviously cannot achieve the regeneration and reconstruction of periodontal tissue.

Method used

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  • Periodontium regeneration and repair membrane and preparation method thereof
  • Periodontium regeneration and repair membrane and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0023] (1) Preparation of fiber membrane material:

[0024] ①Preparation of the spinning solution for the inner layer of the regenerated membrane: Dissolve polyethylene oxide and type I collagen in distilled water according to the formula ratio, and after the two are completely dissolved, add hydroxyapatite according to the formula ratio, and stir for 6-8 hours to obtain Spinning solution for the inner layer of the regenerated membrane, the content of polyethylene oxide in the spinning solution for the inner layer of the regenerated membrane is 10%, and the content of type I collagen is 5%;

[0025] ②Preparation of the material for the outer layer of the regenerated film: add polyvinyl alcohol and modified sodium alginate to distilled water in order to dissolve according to the formula ratio, and then obtain the spinning solution for the outer layer of the regenerated film. The content of polyvinyl alcohol in the outer layer of the regenerated film is 10% , the content of modi...

Embodiment 1

[0030] The present invention prepares a kind of periodontal tissue regeneration repair film according to the above method, wherein the consumption of polyethylene oxide is 10 parts, the consumption of polyvinyl alcohol is 10 parts, the consumption of type I collagen is 10 parts, and the consumption of hydroxyapatite is 10 parts. 0.1 part, the dosage of modified sodium alginate is 2 parts. Wherein in the spinning step of the periodontal tissue regeneration membrane: in the spinning step of the inner layer of the tissue regeneration membrane, the distance between the roller receiver and the spinning nozzle is 15cm; the high voltage power supply is adjusted to 15kV, and the output speed of the syringe pump is adjusted 0.8mL / h, the rotational speed of the roller receiver is set to 200rpm; in the spinning step of the outer layer of the tissue regeneration membrane, the distance between the roller receiver and the spinning nozzle is 15cm; the high voltage power supply is adjusted to ...

Embodiment 2

[0032]The present invention prepares a kind of periodontal tissue regeneration and repairing film according to the above method, wherein the consumption of polyethylene oxide is 40 parts, the consumption of polyvinyl alcohol is 50 parts, the consumption of type I collagen is 15 parts, and the consumption of hydroxyapatite is 0.5 parts, and the dosage of modified sodium alginate is 10 parts. Wherein in the spinning step of the periodontal tissue regeneration membrane: in the spinning step of the inner layer of the tissue regeneration membrane, the distance between the roller receiver and the spinning nozzle is 15cm; the high voltage power supply is adjusted to 15kV, and the output speed of the syringe pump is adjusted 0.8mL / h, the rotational speed of the roller receiver is set to 200rpm; in the spinning step of the outer layer of the tissue regeneration membrane, the distance between the roller receiver and the spinning nozzle is 15cm; the high voltage power supply is adjusted t...

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Abstract

The invention belongs to the technical field of biomedical engineering, in particular to the technical field of preparation of damaged-periodontium repair materials, and discloses a periodontium regeneration and repair membrane and a preparation method thereof. The periodontium regeneration and repair membrane is of a double-layer multihole meshed structure, and is prepared from polyoxyethylene, polyvinyl alcohol, type-I collagen, hydroxyapatite and modified sodium alginate. The periodontium regeneration membrane is low in immunogenicity and high in biocompatibility and induced repair capacity, and has an obvious promoting effect on regeneration of damaged periodontiums.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, in particular to the technical field of preparation of periodontal damaged tissue repair materials, and discloses a periodontal tissue regeneration repair membrane and a preparation method thereof. Background technique [0002] The periodontal tissue structure is complex, including gingiva, periodontal ligament, cementum and alveolar bone. When suffering from infectious diseases such as periodontitis, the connective tissue matrix and cells can be destroyed, thereby making the periodontal ligament cells Loss of fibrous attachment, alveolar bone resorption, and ultimately tooth loss. At present, the conventional periodontitis treatment cannot completely repair the missing periodontal tissue, and the continuous research of tissue engineering technology is improving new directions for clinical treatment. In general, to complete the reconstruction and repair of periodontal tissue loss,...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/16A61L27/18A61L27/20A61L27/24A61L27/50A61L27/56A61L27/58
CPCA61L27/12A61L27/16A61L27/18A61L27/20A61L27/24A61L27/50A61L27/56A61L27/58C08L5/04C08L71/02C08L29/04
Inventor 陈锦涛韦加娜陈泰瀛
Owner GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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