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Janus-structured polyether/Ag particle and preparation method and application thereof

A technology of polyether and particles, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve complex processes, low preparation efficiency, unfavorable environmental protection and mass production, etc. problem, to achieve the effect of narrow size distribution, fast operation process and good biocompatibility

Active Publication Date: 2018-03-23
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the special microstructure of Janus particles, when using the existing emulsion method, microfluidic method, template method and other methods to prepare Janus particles, it is inevitable to use a variety of solvents, the process is complicated, the preparation efficiency is low, and it is not conducive to environmental protection. and mass production

Method used

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  • Janus-structured polyether/Ag particle and preparation method and application thereof
  • Janus-structured polyether/Ag particle and preparation method and application thereof
  • Janus-structured polyether/Ag particle and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A kind of preparation method of Janus structure polyether / Ag particle, concrete preparation steps are as follows:

[0025] a) Preparation of mercaptopolyetheramine

[0026] Dissolve 2 g of polyethylene glycol diglycidyl ether (number average molecular weight Mn=500 g / mol) and 0.308 g of mercaptoethylamine in 10 mL of absolute ethanol, react at 80°C for 10 hours, and precipitate the reaction mixture into n-hexane, separated and dried to obtain mercaptopolyetheramine. The nuclear magnetic spectrum of gained mercapto polyether amine is shown in figure 1 (The peaks with chemical shifts of 1.3, 2.4~2.8, and 3.6 belong to the thiol group on the molecular chain of mercaptopolyetheramine, the methylene group adjacent to the nitrogen atom, and the hydrogen atom on polyethylene glycol, respectively);

[0027] b) Preparation of Janus structured polyether / Ag particles

[0028] The above 20 mg mercaptopolyetheramine, 4 mg AgNO 3 Dissolved in 20 mL of water and irradiated with 36...

Embodiment 2

[0030] A kind of preparation method of Janus structure polyether / Ag particle, concrete preparation steps are as follows:

[0031] a) Preparation of mercaptopolyetheramine

[0032] 2 g of polyethylene glycol diglycidyl ether (number-average molecular weight Mn=500 g / mol) and 0.308 g of mercaptopropylamine were dissolved in 10 mL of absolute ethanol, and reacted at 70°C for 15 hours, and the reaction mixture was precipitated to In n-hexane, separate and dry to obtain mercaptopolyetheramine;

[0033] b) Preparation of Janus structured polyether / Ag particles

[0034] The above 20 mg mercaptopolyetheramine, 6 mg AgNO 3 Dissolve in 20 mL of water, and irradiate under 450 nm ultraviolet light for 10 minutes to obtain a Janus structure polyether / Ag particle aqueous solution; it is obtained after separation and drying.

Embodiment 3

[0036] A kind of preparation method of Janus structure polyether / Ag particle, concrete preparation steps are as follows:

[0037] a) Preparation of mercaptopolyetheramine

[0038] 2 g of polyethylene glycol diglycidyl ether (number-average molecular weight Mn=500 g / mol) and 0.308 g of mercaptoethylamine, dissolved in 10 mL of N,N-dimethylformamide, reacted at 90°C for 6 hours , precipitate the reaction mixture into n-hexane, separate and dry to obtain mercaptopolyetheramine;

[0039] b) Preparation of Janus structured polyether / Ag particles

[0040] The above 20 mg mercaptopolyetheramine, 10 mg AgNO 3 Dissolve in 20 mL of water and irradiate under sunlight for 20 minutes to obtain a Janus structure polyether / Ag particle aqueous solution; obtain it after separation and drying.

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Abstract

The invention relates to a preparation method of a Janus-structured polyether / Ag particle. Sulfydryl polyether amine and soluble silver salt are dissolved in water, so that a solution A is obtained, and after sunlight or ultraviolet irradiation, separation and drying, the Janus-structured polyether / Ag particle is obtained; sulfydryl aliphatic amine and poly(ethylene glycol) diglycidyl ether undergo nucleophilic addition-ring-opening polymerization, so that the sulfydryl polyether amine is obtained, a structural formula of a constitutional unit of the sulfydryl polyether amine is shown in the description; in the formula, m is equal to 2 to 4, n is equal to 5 to 250, and both m and n are integers. The method disclosed by the invention has the characteristics of mild reaction conditions and rapid, simple and environment-friendly operation process; the prepared Janus-structured polyether / Ag particle has the characteristics of small grain size, narrow size distribution and good biocompatibility, and can be used as an antibacterial agent, and moreover, the surface of an Ag phase of the Janus particle can be further functionalized, so that the application range of the Janus-structured polyether / Ag particle can be broadened.

Description

technical field [0001] The invention belongs to the technical field of nanoparticle synthesis, and in particular relates to a Janus structure polyether / Ag hybrid nanoparticle, a preparation method and application thereof. Background technique [0002] In 1991, the famous French scientist de Gennes used "Janus" for the first time in his Nobel Prize-winning speech to describe those colloidal particles with chemical asymmetry, such as hydrophilic-hydrophobic, polar-nonpolar and morphological asymmetry sex etc. This asymmetry endows Janus particles with special microstructure and functional properties, making them extremely broad in fields such as emulsifiers, nanomotors, magnetic responses, optical sensing, electronic paper, interface catalysis, drug carriers, and biotechnology. The application prospect has become a new research hotspot in the field of materials research in recent years. [0003] The preparation method of Janus particles is varied, such as the Pickering emuls...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/34A61K33/38A61P31/04
CPCA61K9/1641A61K9/1682A61K33/38Y02A50/30
Inventor 任艳蓉徐梦达
Owner HENAN UNIVERSITY
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