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Intravascular stent comprising biodegradable macromolecular coating

A polymer coating, biodegradable technology, applied in the field of stents, can solve the problems of low drug release rate, short effective time, etc., to improve the release efficiency, prolong the release time, good biocompatibility and degradability. Effect

Inactive Publication Date: 2018-03-20
成都测迪森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In bioreduced polymer materials, the drug release rate is low and the effective time is short.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0020] Specific embodiment 1: A polylysine for stent coating, the preparation method is as follows:

[0021] Step 1. Connect the strain to a culture medium for cultivation, and cultivate it at 25-30°C for 40 hours. The medium includes 100 parts by weight of distilled water, 2 parts of glucose, sodium chloride: 0.1 part, chlorine Calcium chloride: 0.1 part, ammonium chloride: 0.1 part, magnesium chloride: 0.1 part, and the pH value of the medium is 6.5.

[0022] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate for 48 hours at 25-30°C; the said fermentation medium includes 100 parts by weight of distilled water, 0.2 parts of peptone, and yeast Ointment 0.2 parts, glycerol 0.5 parts, glucose 0.5 parts, and the pH value of the fermentation medium is 6.5.

[0023] Step 3. Centrifuge the fermentation broth for 20 minutes, collect the cells, and heat it in a water bath, then take the supernatant and...

specific Embodiment 2

[0025] Specific embodiment 2: A polylysine for stent coating, the preparation method is as follows:

[0026] Step 1. Connect the strains to a culture medium for cultivation, and cultivate at 25°C for 40 hours. The culture medium includes 100 parts by weight of distilled water, 2 parts of glucose, sodium chloride: 0.1 part, calcium chloride : 0.1 part, ammonium chloride: 0.1 part, magnesium chloride: 0.1 part, the pH value of the medium is 6.5.

[0027] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate for 48 hours at 25°C; the said fermentation medium includes: 100 parts by weight of distilled water, 0.2 parts of peptone, and 0.2 parts of yeast extract. The pH value of the fermentation medium is 6.5.

[0028] Step 3. Centrifuge the fermentation broth for 20 minutes, collect the cells, and heat it in a water bath, then take the supernatant and drain the water to prepare polylysine;

[0029] Step...

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PUM

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Abstract

The invention discloses a vascular stent containing a biodegradable polymer coating, which belongs to the medical field. The preparation method is as follows: step 1, inserting the bacterial strain into a medium for cultivation, and culturing at 25-30°C for 40 hours; Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate it at 25-30°C for 48 hours; Step 3. Centrifuge the above-mentioned fermentation solution for 20 minutes, collect the cells, and heat them in a water bath. Take the supernatant, drain the water, and prepare polylysine; step 4: dissolve 2-amino-3-p-hydroxyphenylpropionic acid monomer and peroxide initiator in an organic solvent to prepare a solution; Secondly, it is mixed with the prepared polylysine powder, and the mixture is grafted and modified by melt grafting reaction equipment to obtain polylysine grafted 2-amino-3-p-hydroxyphenylpropionic acid biodegradable polymer.

Description

Technical field [0001] The invention relates to the field of stents. Background technique [0002] Stent, also known as coronary stent, is a commonly used medical device in interventional heart surgery and has the function of dredging arteries. The main material is stainless steel, nickel-titanium alloy or cobalt-chromium alloy. [0003] Existing metal stents easily lead to restenosis of blood vessels. In a new type of stent, antithrombotic and anti-proliferative drugs are wrapped on the heart stent. After the stent is implanted, the drugs are slowly released, which can increase the local drug concentration, reduce side effects, and reduce the rate of restenosis. [0004] The existing drug carriers generally include biodegradable and non-degradable polymer materials. In the biodegradable polymer materials, the release rate of the drug is low and the effective time is short. Summary of the invention [0005] The purpose of the present invention is to provide a vascular stent contain...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/02A61L31/14C08G69/48C12P13/02
CPCA61L31/10A61L31/022A61L31/148A61L2300/602C08G69/48C12P13/02C08L77/04
Inventor 郑浩
Owner 成都测迪森生物科技有限公司
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