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Preparation method of intravascular stent with drug coating

A vascular stent and drug coating technology, applied in the medical field, can solve the problems of insufficient drug and short release time, and achieve the effects of long release time, high release rate and improved adhesion

Inactive Publication Date: 2018-04-06
CHENGDU SHENGERJIA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But when polymalic acid is introduced into the stent, because the coating on the surface of the stent is very thin, the drug that can be loaded is not enough, the release time is short, and a large amount of drug will be released in a short time

Method used

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Examples

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specific Embodiment 1

[0025] Specific embodiment 1: a kind of vascular stent with drug coating, vascular stent comprises stent body and drug coating, and described stent body is made of titanium alloy material, and the preparation method of described vascular stent is as follows:

[0026] Step 1, treating the titanium alloy stent at high temperature under an inert gas environment for 1 to 2 hours;

[0027] Step 2, cooling to normal temperature at the temperature, and processing for 5 hours;

[0028] Step 3: further heat up the titanium alloy, pass hydrochloric acid vapor under inert gas or vacuum environment, and treat with hydrochloric acid vapor for 4 minutes.

[0029] Step 4, the above-mentioned treated titanium alloy is lowered to room temperature;

[0030] Step 5. Put the above-mentioned titanium alloy into organic acid, soak it, remove and dry it, put it into a solvent, and clean it by ultrasonic wave for 50 minutes to remove the titanium alloy bracket;

[0031] Step 7, mixing polymalic aci...

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Abstract

The invention discloses a method for preparing a blood vessel stent with a drug coating, which belongs to the medical field. The blood vessel stent includes a stent body and a drug coating, and the stent body is made of a titanium alloy material.

Description

technical field [0001] The present invention relates to the medical field. Background technique [0002] Cardiac stent (Stent), also known as coronary stent, is a medical device commonly used in cardiac interventional surgery and has the function of dredging arteries. The main materials are stainless steel, nickel-titanium alloy or cobalt-chromium alloy. [0003] Existing metal stents easily lead to restenosis of blood vessels. In a new type of stent, anti-thrombotic and anti-proliferative drugs are wrapped on the heart stent. After the stent is implanted, the drug is released slowly, which can increase the local drug concentration, reduce side effects, and reduce the rate of restenosis. [0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In biodegradable polymer materials, the drug release rate is low and the effective time is short. The commonly used degradable material carriers include polylactic acid, polyglycolic acid...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/34A61L27/54C22C14/00
CPCA61L27/06A61L27/34A61L27/54A61L2300/216A61L2300/604A61L2420/02C22C14/00C08L67/04
Inventor 卢晔
Owner CHENGDU SHENGERJIA SCI & TECH
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