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Pet dog calcium enriching soft capsule recipe and preparation method thereof

A soft capsule, pet dog technology, applied in the directions of capsule delivery, drug combination, pharmaceutical formula, etc., can solve the problems of low absorption and utilization rate, easy to constipation, cardiopulmonary compensation burden, etc., to facilitate transportation and use, improve calcium element The effect of simple deposition and preparation process

Inactive Publication Date: 2018-03-09
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (1) The calcium sources used in general powders are inorganic calcium, calcium propionate, and calcium carbonate. This calcium source needs to be decomposed by gastric acid in the pet body to generate calcium ions for absorption. The absorption utilization rate is very low, and Some are prone to constipation, etc.
[0007] (2) There are also some selected organic acid calcium, such as calcium gluconate, calcium lactate, calcium citrate, etc. This calcium agent is decomposed into calcium ions and other organic acids in the body, and the organic acid needs to be metabolized by the kidney and liver. For middle-aged and elderly young dogs, the burden on the kidneys and liver increases, which can easily cause cardiopulmonary compensation, and the dissociated unabsorbed calcium ions are likely to form gelatinous calcium hydroxide in the alkaline small intestinal fluid, which is not conducive to the health of animals.
[0014] "A Pearl Soybean Calcium Soft Capsule Suitable for Women and Its Preparation Method (CN 102630946A; Publication Date: 2012.08.15)" is in the form of a capsule, and there is no vitamin in this formula to assist absorption. The second is calcium carbonate. The most important component of pearl powder, the content is generally above 90%, calcium carbonate is added to the formula, the content of inorganic calcium is too large, the formula is unreasonable, and the particle size of pearl powder is generally large, it is made into a suspension and directly pressed into the capsule , oil leakage from cracks often occurs in production
[0015] "Calcium Supplement Preparation and Preparation Method (CN1759851A; Publication Date: 2006.04.19)", this patent is Chinese medicine water extract capsules. In the prescription, inorganic acid calcium is used to stimulate the stomach. time consuming

Method used

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  • Pet dog calcium enriching soft capsule recipe and preparation method thereof
  • Pet dog calcium enriching soft capsule recipe and preparation method thereof
  • Pet dog calcium enriching soft capsule recipe and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]

[0043]

[0044]

[0045] Note: All the components of the mixture in Examples 1-6, the addition amount is 1:1 mass ratio, and the essence is the addition amount of 40kg capsule skin liquid.

[0046] Preparation method:

[0047] (1) Heat the carrier and maintain it at 60-80°C, add antioxidants, and keep stirring until the two are completely fused, the solution is transparent and clear, and A liquid is obtained;

[0048] (2) cooling liquid A to room temperature, adding vitamin A and vitamin D, and stirring evenly to obtain liquid B;

[0049] (3) Add the organic calcium source and the chelated calcium source crushed to 40-80nm in the B liquid and fully mix to obtain a semi-finished product, and inject the capsule after the semi-finished product is qualified;

[0050] (4) Heat deionized water to 60-70°C, put in medical gelatin, and stir fully, dissolve and clarify, add glycerin, stir evenly, add essence, filter through 80-mesh screen, keep warm at 60°C to obtain ...

Embodiment 7

[0052] Example 7: Clinical Trial of Calcium Supplementation in Middle-aged and Elderly Dogs

[0053] 1. Materials

[0054] Negative control group: distilled water

[0055] Positive control group: commercially available calcium supplement capsules

Embodiment 1-6

[0056] Example 1-6 Sample group: Calcium supplement soft capsules for pet dogs.

[0057] 2. Method

[0058] 24 healthy middle-aged and adult small dogs were selected, randomly divided into 8 groups, 3 dogs in each group, and raised in captive kennels respectively. The test dogs in the 8 groups had similar body weights, and the personnel management and feeding conditions were the same.

[0059] The negative control group was given distilled water, the positive control group was given the vitamin soft capsules sold on the market, and fed according to the dosage on the instructions, and the sample group was given the pet dog calcium supplement soft capsules prepared according to Examples 1-6, according to the same dosage For feeding. After 3 days of continuous use, plasma serum calcium was measured.

[0060] The test results are as follows:

[0061]

[0062] As can be seen from the experimental results, the plasma serum calcium concentration of the negative control group was ...

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Abstract

The invention relates to a pet dog calcium enriching soft capsule recipe and a preparation method thereof. The pet dog calcium enriching soft capsule recipe is prepared from an organic calcium source,a chelating calcium source, vitamin D, vitamin E, antioxidants and carriers. A soft capsule case is prepared from gelatin, glycerin, essence and water. The materials are prepared into the faint yellow to dark yellow soft capsule with the obvious fragrance through a special process. The pet dog calcium enriching soft capsule recipe has the advantages that the preparation process is simple; the content is stable; the clinic use is easy, and the like. Compared with an inorganic calcium preparation, the soft capsule recipe has the advantages that the safety is higher; the gastric acid reaction for calcium ion release is not needed. Compared with some calcium preparations, the soft capsule recipe has the advantages that the essence is added; the food refusal of pets in the clinic use process cannot occur; convenience is greater. The chelating calcium is used in the recipe, so that the absorption rate is as high as 90 percent; the utilization rate is three times of that of other calcium preparations; the clinic curative effect is more obvious.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a formula and a preparation method of calcium-supplementing soft capsules for pet dogs. Background technique [0002] At present, my country has about 150 million pet dogs and 30-50 million cats. The direct output value of the entire pet industry is estimated to be more than 40 billion yuan. With the continuous development of society and the continuous improvement of people's living standards, pets play an important role in society and families, such as search and rescue dogs, shepherd dogs, guide dogs and other working dogs, as well as docile families as "companions" canines. According to a conservative estimate, there are at least 100 million pets in my country at present, and the market potential of the pet economy can be as high as more than 15 billion. All this is still going up. The aging of the population is intensifying, the elderly lack companio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/618A61K9/48A61P3/02A61K31/195A61K31/198A61K31/593A61K31/355
CPCA61K9/4816A61K31/195A61K31/198A61K31/355A61K31/593A61K35/618A61K2300/00
Inventor 李梁李旭东刘爱玲夏雪林王娟
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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