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Fu tea extract and application thereof in regulating blood lipid and liver fat

An extract and technology of Fucha, applied in the field of Fucha extract and its application in regulating blood lipid and liver fat, can solve the problems of reducing blood lipid and liver fat, and achieve the effect of no toxic side effects and great application potential

Inactive Publication Date: 2018-03-06
INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no relevant report on the research and work on the research and work on the extraction of Fucha with organic reagents or the extract after supercritical extraction to reduce blood lipids and liver fat

Method used

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  • Fu tea extract and application thereof in regulating blood lipid and liver fat
  • Fu tea extract and application thereof in regulating blood lipid and liver fat
  • Fu tea extract and application thereof in regulating blood lipid and liver fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Ethanol extraction: adding 8 times of ethanol to Fu tea according to the weight ratio for thermal extraction, the extraction temperature is the reflux temperature of ethanol, each extraction is 5 hours, a total of 3 extractions, after the extraction is completed, the supernatant is filtered and concentrated for later use, and the present invention is obtained Fu tea extract provided. Wherein, the extraction rate of Fu tea extract is 15%.

[0047] Ethanol and water are mixed and extracted in an equal volume ratio: the fermented Fu tea is mixed with 8 times of ethanol and 8 times of water according to the weight ratio for thermal extraction. The extraction temperature is the reflux temperature of ethanol. Each extraction is 5 hours, and a total of 3 extractions are made. After the extraction is completed, the supernatant is filtered and concentrated for later use, and the Fucha extract provided by the present invention is obtained. Wherein, the extraction rate of Fu tea ...

Embodiment 2

[0049] Methanol extraction: Add 8 times of methanol to the Fucha according to the weight ratio, soak and cold extract at room temperature 25°C, extract for 5 hours each time, and extract 3 times in total. After the extraction is completed, take the supernatant, filter and concentrate for later use, and obtain the Fucha provided by the present invention. Extract. Wherein, the extraction rate of Fu tea extract is 12%.

Embodiment 3

[0051] Ethyl acetate extraction: Add 8 times of ethyl acetate to Fu tea according to the weight ratio for ultrasonic extraction, each extraction is 5 hours, and the ultrasonic power is 500W for each extraction, a total of 3 extractions, the supernatant is filtered and concentrated for later use. That is, the Fucha extract provided by the present invention is obtained. Wherein, the extraction rate of Fu tea extract is 11%.

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Abstract

The invention discloses fu tea extract and application thereof in regulating blood lipid and liver fat. The method for preparing the fu tea extract comprises the following steps that with fu tea beinga raw material, organic solvent or CO2 is used for extraction, and after the extraction is completed, the fu tea extract is obtained. A medicine effect test shows that after the fu tea extract is therapeutically applied to a model of ICR mice fed by high-fat feed for four weeks, when the tested extract is at the high dosage of 500 mg / kg, the fu tea extract has the obvious effects on lowering blood lipid relevant important indexes of total cholesterol, triglyceride and low density lipoprotein cholesterin in serum; when at the dosage of 200 mg / kg-500 mg / kg, the extract has the obvious effect onlowering mouse liver fat relevant indexes of total cholesterol and triglyceride and basically has no toxic and side effect. The fu tea extract has very large application potential in the aspects of preparing lipid-lowering drugs.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to an extract of Fu tea and its application in regulating blood fat and liver fat. Background technique [0002] Blood lipids refer to the general term for lipids such as triglycerides, cholesterol and fatty acids in plasma. When the blood lipid concentration in the serum exceeds the upper limit of the clinical normal level, it is hyperlipidemia. Hyperlipidemia is a common and multiple metabolic disease. Clinically, hyperlipidemia is mainly manifested as serum triglyceride (TG, adult normal value 0.22-1.21mmol / L (20-110mg / dl), total cholesterol (TC, adult normal value 2.86-5.98mmol / L or 110- 230mg / dl) and low-density lipoprotein cholesterol (LDL-C, adult normal value <3.12mmol / L (120mg / dl) levels are too high, or serum high-density lipoprotein cholesterol (HDL-C, adult normal value 0.9-2.19 The level of mmol / L (35-85mg / dI) is too low. In addition to genetic fact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/062A61P3/06A61P1/16
CPCA61K36/062A61K2236/333A61K2236/37
Inventor 宋福行王龙
Owner INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
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