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Nano insulin-chitosan manufactured through pressurization and vibration packing method

A technology of insulin and chitosan, which is applied in the direction of medical preparations containing active ingredients, metabolic diseases, peptide/protein components, etc., can solve the problems of failing to truly display insulin-chitosan

Inactive Publication Date: 2018-02-09
锡山区东港全宝机械经营部
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of my country's various chitosan products are ordinary size insulin-chitosan, which fails to truly show the full picture of the biological activity and excellent medical properties of insulin-chitosan, and the intervention of nanotechnology is the way to solve the above problems

Method used

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  • Nano insulin-chitosan manufactured through pressurization and vibration packing method

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Experimental program
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Embodiment Construction

[0018] 1.1 Materials

[0019] Chitosan (CS, molecular weight 5000Da, deacetylation degree 85%), Zhejiang Aoxing. DL-Lipoic Acid 99% (LA), Stearic Acid 98% (SA), 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride (EDC), N-Hydroxysuccinate Imide (NHS) and dithiothreitol (DTT) were purchased from Aladdin Reagents (China) Co., Ltd. Formic acid solution (concentration: 88%), formaldehyde solution (concentration: 40%), and absolute ethanol were all of analytical grade and purchased from Tianjin Reagent Wholesale Company.

[0020] 1.2 Preparation of grafted chitosan

[0021] Get 1g chitosan and be dissolved in 70mL deionized water, stearic acid (the mol ratio of the amino group of stearic acid and chitosan is 0.2:1) and 1.6g EDC and 0.95g NHS are dissolved in 35mL ethanol (EDC and The molar ratio of NHS to carboxyl group is 10:1), pre-reacted at room temperature for 0.5h, then added dropwise into chitosan aqueous solution, and reacted at 60°C for 2d. After the reaction, ...

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Abstract

The present invention relates to nano-insulin-chitosan produced by a pressurized vibration wrapping method, the inner core is nano-insulin-chitosan, the outer layer is a polymer coating layer, and the polymer on the surface of nano-insulin-chitosan is The polymer coating layer is uneven, and the surface of a single nano-insulin-chitosan is partially covered with a high molecular polymer coating layer, and some parts are not covered with a high molecular polymer coating layer. In the above nano-insulin-chitosan production process, evenly disperse the nano-insulin-chitosan powder, spread it flat on a circular plane with sufficient surface strength and surrounding circles, and then spread another flat The round surface with smooth and sufficient hardness is pressed on the nano-insulin-chitosan powder for pre-pressurization. The two circular planes have equal areas, and the upper surface is embedded in the lower surface enclosure; then vibrate, pressurize while vibrating. The required pressure, then dropwise add the polymer solution around the nano-insulin-chitosan powder, just moisten it, and keep ventilated at room temperature until the solution evaporates completely.

Description

technical field [0001] The invention relates to nano insulin-chitosan produced by a pressurized vibration encapsulation method. Background technique [0002] Insulin is a protein hormone secreted by the islet β cells in the pancreas when stimulated by endogenous or exogenous substances such as glucose, lactose, ribose, arginine, and glucagon. Insulin is the only hormone in the body that lowers blood sugar, and at the same time promotes the synthesis of glycogen, fat, and protein. Exogenous insulin is mainly used to treat diabetes. [0003] Nano-chitosan is currently one of the most important nanotechnology products, widely used in biopharmaceuticals, disease diagnosis, purification treatment, environmental monitoring, paint coatings, cosmetics and many other fields. When nano-chitosan is used as a drug carrier, its ultra-small volume is easier to pass through the interstitial space, and directly transport the loaded drug to the target site through the capillary wall, gastr...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61K9/52A61K9/51A61K47/36A61K47/34A61K47/10A61P3/10
CPCA61K38/28A61K9/0002A61K9/5146A61K9/5161A61K9/5192
Inventor 王全宝
Owner 锡山区东港全宝机械经营部
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