Compound macleaya cordata composition used for treating animal diarrheal diseases

A technology of Boluohui and composition, which is applied in the field of compound Boluohui composition preparation, which can solve problems affecting the clinical efficacy of drugs, achieve the effect of solving the problem of high residues, increasing quality and safety, and improving the efficacy of drugs

Active Publication Date: 2018-01-26
四川吉星动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term human consumption of animal foods and Chinese patent medicine health foods containing low concentrations of quinolones can easily induce the transmission of drug resistance, thereby affecting the clinical efficacy of such drugs

Method used

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  • Compound macleaya cordata composition used for treating animal diarrheal diseases
  • Compound macleaya cordata composition used for treating animal diarrheal diseases
  • Compound macleaya cordata composition used for treating animal diarrheal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-10

[0056] The prescription (5 mL) of compound Boluohui injection for treating diarrheal diseases in animals of the present invention is as follows.

[0057] Table 3. Example 1-10 formulations.

[0058]

[0059] Note: q.s. means appropriate amount and sufficient amount.

[0060] The preparation method includes the following steps.

[0061] (1) Dissolve antioxidants, metal ion chelating agents, antibacterial (pain-relieving) agents, and freezing point regulators in water for injection saturated with carbon dioxide or nitrogen, then add quinolones and stir to dissolve them.

[0062] (2) In addition, use the extraction method of acid extraction, alkali precipitation, and alcohol reflux collection, that is, take Boluo back to the fruit pods, extract with 20 times the amount of 0.5% acid aqueous solution, and then adjust the pH to 8-10 with alkali, after separation and precipitation, Then extract with 90% ethanol to obtain the total alkaloids of Boluohui, and the extraction rate...

Embodiment 11-20

[0065] The prescription of the compound Boluohui injection (emulsion injection, 100 mL) for treating yellow and white scour of piglets of the present invention is as follows.

[0066] Table 4. Example 11-20 formulations.

[0067]

[0068] Note: q.s. means appropriate amount, sufficient amount.

[0069] The preparation method includes the following steps.

[0070] (1) Use the extraction method of acid extraction, alkali precipitation, and alcohol reflux collection, and another extraction method of acid extraction, alkali precipitation, and alcohol reflux collection, that is, take Boluo back to the fruit pods, extract with 20 times the amount of 0.5% acid aqueous solution, and then Adjust the pH to 8-10 with alkali, separate and precipitate, and then extract with 90% ethanol to obtain the total alkaloids of Boluohui, and the extraction rate is not less than 60%; (2) Preparation of oil phase: Boluohui The total alkaloid extract and antioxidant are added to the soybean oil,...

Embodiment 21-30

[0076] The prescription of a compound Bo Luohui injection (suspension injection or sterile powder for injection, 20 mL) for treating yellow and white scour of piglets of the present invention is as follows.

[0077] Table 5. Example 21-30 formulations.

[0078]

[0079] The preparation method includes the following steps.

[0080] (1) Use the extraction method of acid extraction, alkali precipitation, and alcohol reflux collection, and another extraction method of acid extraction, alkali precipitation, and alcohol reflux collection, that is, take Boluo back to the fruit pods, extract with 20 times the amount of 0.5% acid aqueous solution, and then Adjust the pH to 8-10 with alkali, separate the precipitate, and then extract with 90% ethanol to obtain the total alkaloids of Boluohui, and the extraction rate is not less than 60%.

[0081] (2) Add antioxidants, metal ion chelating agents, antibacterial (pain-relieving) agents, buffer salt ion pairs, freezing point regulator...

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Abstract

The invention discloses a compound macleaya cordata composition used for treating animal diarrheal diseases, and belongs to the field of veterinary drug. The compound macleaya cordata composition contains macleaya cordata total alkaloids extract and quinolone compounds, and contains following active components, by mass, 1 to 1000 parts of macleaya cordata total alkaloids extract, and 1 to 2000 parts of quinolone compounds. The compound macleaya cordata composition can be prepared into solid preparations including liquid preparations such as injections, syrup, and oral solution, tablets, dispersing tablets, sustained release tablets, capsules, particles, and powder, and semi-solid preparations such as ointment, paste, and gel. Obvious synergistic effects are achieved in treatment of animaldiarrheal diseases using the compound macleaya cordata composition, infection of diseases can be controlled effectively, curative effect is obvious, quality is stable, safety is high, the preparationmethod is simple, and the preparation method is suitable for industrialized production.

Description

technical field [0001] The invention relates to a veterinary compound preparation for treating animal diarrhea and its application. It belongs to the field of veterinary medicine. Background technique [0002] "The country is based on the people, and the people depend on food." At present, due to the continuous emergence and mutation of various animal pathogens, the development of my country's livestock and poultry industry has caused serious harm, which has a potential impact on national life and health to a certain extent. A variety of pathogens, such as bacteria, can cause diarrheal diseases in animals. The main target organs of such diseases are the digestive tract and gastrointestinal tract, resulting in impaired nutrient absorption in animals, increased intestinal content, and clinical symptoms such as vomiting, diarrhea, and dehydration. The mortality rate of older animals is extremely high. [0003] Among them, piglet yellow and white scour is a common and frequent...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K47/02A61K47/10A61K47/26A61P1/12A61P31/04A61K31/496A61K31/5383A61K31/4709
Inventor 张凌
Owner 四川吉星动物药业有限公司
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