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Pseudo-ginseng oil dropping pill and preparation method thereof

A technology of oil dripping pills and Panax notoginseng oil, which is applied in the field of Panax notoginseng oil dripping pills and its preparation, can solve the problems of high frequency and dosage, no patent of Panax notoginseng oil, and low bioavailability, and achieve a small dosage , The process conditions are easy to control, and the effect of taking less times

Inactive Publication Date: 2018-01-16
东莞暨南大学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the domestic and foreign patents on Sanqi dripping pills are mainly compound preparations, such as "Sanqi Guanxinning Dripping Pills", the patent number is CN200610054829.5; "A Chinese medicine compound Sanqi dropping pills and its preparation method", the patent number CN02103920.8, etc.; there are also related patents on Panax notoginseng single herb, but they are still in the review or review stage, such as "Notoginseng saponin dripping pills", patent number CN2003101219101.8; "Notoginseng dripping pills and its preparation method" , Patent No. CN200810083835.2, etc., and there is no patent related to Panax notoginseng oil
[0006] On the other hand, there are currently no Panax notoginseng oil-related products on the market. Most Panax notoginseng products on the market are in the form of compound formulations. For children with Panax notoginseng alone, there are mainly Panax notoginseng powder, Panax notoginseng tablets, and Panax notoginseng broken wall slices. On the one hand, it is inconvenient to take because of the high frequency and amount of taking; on the other hand, these products are mainly made of Panax notoginseng raw materials, and the bioavailability is low. Therefore, it is urgent to develop a dosage form that is easy to take and carry for its Panax notoginseng oil

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of Panax notoginseng oil dripping pill, the Panax notoginseng oil is made with supercritical CO 2 Made by extraction;

[0025] Precisely weigh 20g of PEG4000 in a heating container, heat and melt at 75°C, add 10mL of Panax notoginseng oil, heat and melt, mix well, keep the temperature at 75°C for standby; start the dropping pill machine, and keep the dropper temperature at 75°C , so that the temperature of the condensing agent in the condensing column of the dropping pill machine is 10°C; then the molten mixture is formed by the dropper of the dropping pill machine and dropped into the condensing agent liquid paraffin, and the drop speed is adjusted to be 20 drops / min, and the drop distance is 5cm, take out the shrinkage-molded dropping pills from the outlet of the dropping pill machine, remove the condensing agent on the surface, dry, inspect, and pack. Using drippers with different diameters respectively, the average weight of the prepared Panax notoginseng oi...

Embodiment 2

[0028] Precisely weigh 50g of PEG4000 in a heating container, heat and melt at 75°C, add 10mL of Panax notoginseng oil, heat and melt, mix well, keep the temperature at 75°C for standby; start the dropping pill machine, and keep the dropper temperature of the dropping pill machine at 75°C , so that the temperature of the condensing agent in the condensing column of the dropping pill machine is 8°C; then the molten mixture is formed by the dropper of the dropping pill machine and dropped into the condensing agent liquid paraffin, and the drop speed is adjusted to be 30 drops / min, and the drop distance is 5cm, take out the shrinkage-molded dropping pills from the outlet of the dropping pill machine, remove the condensing agent on the surface, dry, inspect, and pack. Using drippers with different diameters respectively, the average weight of the prepared Panax notoginseng oil dripping pills is 20-75mg.

[0029] The dripping pills prepared above have a round shape, uniform color, ...

Embodiment 3

[0031] Precisely weigh 80g of PEG4000 in a heating container, heat and melt at 75°C, add 10mL of Panax notoginseng oil, heat and melt, mix well, keep the temperature at 75°C for standby; start the dropping pill machine, and keep the dripper temperature at 75°C , so that the temperature of the condensing agent in the condensing column of the dropping pill machine is 5°C; then the molten mixture is formed by the dropper of the dropping pill machine and dropped into the condensing agent liquid paraffin, and the drop speed is adjusted to be 50 drops / min, and the drop distance is 8cm, take out the shrinkage-molded dropping pills from the outlet of the dropping pill machine, remove the condensing agent on the surface, dry, inspect, and pack. Using drippers with different diameters respectively, the average weight of the prepared Panax notoginseng oil dripping pills is 20-75mg.

[0032] The dripping pills prepared above have a round shape, uniform color, moderate hardness, a dissolut...

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Abstract

The invention discloses a pseudo-ginseng oil dropping pill and a preparation method thereof. The pseudo-ginseng oil dropping pill mainly comprises pseudo-ginseng oil as a raw material and an auxiliarymaterial matrix according to a volume-weight ratio of 1: 2-8 mL: g. The matrix comprises one or more of polyethylene glycol, polyoxyl 40 stearate, poloxamer, sodium stearate, stearic acid, gelatin, glycerol gelatin, Tween, glyceryl monostearate, hydrogenated vegetable oil, stearyl alcohol and cetyl alcohol. The pseudo-ginseng oil in the pseudo-ginseng oil dropping pill comprises concentrate of multiple active ingredients. Compared with other raw material products, the pseudo-ginseng oil has high active ingredient content. Under the same active ingredient intake, the single dose is small, taking frequency is less and use is convenient. The invention provides the novel pseudo-ginseng preparation which is easy to carry and use, widens a pseudo-ginseng application field and enriches the functional food industry structure.

Description

technical field [0001] The invention belongs to the technical field of application of Chinese medicinal materials, and in particular relates to a notoginseng oil dripping pill and a preparation method thereof. Background technique [0002] Panax notoginseng is the dried root and rhizome of Panax notoginseng Burk.F.H.Chen of Araliaceae. It is one of the precious Chinese medicinal materials commonly used in clinic. Sweet in nature, slightly bitter, warm, returns liver, stomach meridian. It has the effects of dissipating blood stasis and hemostasis, reducing swelling and relieving pain. Indications for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic bleeding, chest and abdomen tingling, tumbling and swelling embolism. [0003] Panax notoginseng mainly contains saponins, flavonoids, polysaccharides, volatile oils, amino acids, sterols, inorganic compounds and other components. Saponins are the main chemical components and effective components of Pana...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/20A61P7/00A61P9/00A61P25/00A61P43/00A61P29/00A61P35/00A61P39/06A61P37/04
Inventor 蒋杰麦丽谊安金蒙罗芮李沙
Owner 东莞暨南大学研究院
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