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Kaempferol nanometer composition and its preparation method and application

A nano-composition, kaempferol technology, applied in the field of kaempferol nano-composition and its preparation, can solve the problems of easy oxidation of kaempferol, poor fat-solubility and water-solubility, poor stability, etc., to achieve easy process control, simple preparation method, Small effect on skin irritation

Inactive Publication Date: 2017-12-22
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, kaempferol itself has certain defects, which restrict its research and application.
Kaempferol has the following two defects in application: the one, the kaempferol fat-water partition coefficient (logP) is 1.9, fat solubility and water solubility are all relatively poor, the water-soluble kaempferol composition of prior art preparation its kaempferol The drug loading is only 0.01 to 1.0%, and the low content makes it difficult for kaempferol to achieve the drug effect; the second is that kaempferol is easily oxidized and has poor stability
These defects severely limit the wide application of kaempferol in clinical

Method used

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  • Kaempferol nanometer composition and its preparation method and application
  • Kaempferol nanometer composition and its preparation method and application
  • Kaempferol nanometer composition and its preparation method and application

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preparation example Construction

[0030] The present invention also provides a preparation method of the kaempferol nano composition described in the above technical solution, comprising the following steps of mixing kaempferol, emulsifier, co-emulsifier, liquid lipid and polyol to obtain the kaempferol nano composition.

[0031] In the present invention, there is no special limitation on the order of adding kaempferol, emulsifier, co-emulsifier, liquid lipid and polyol, and the order of addition well-known to those skilled in the art can be adopted. In the present invention, the emulsifier, co-emulsifier, liquid lipid and polyol are preferably dissolved to obtain an oil phase, and then the kaempferol is mixed with the oil phase to obtain a kaempferol nano composition. In the present invention, the temperature for dissolving and preparing the oil phase is preferably 40-80°C, more preferably 60-70°C; the time for dissolving is preferably 10-30 minutes, more preferably 20-25 minutes. In the present invention, th...

Embodiment 1

[0039] 6.0% Tween 60, 2.0% polyoxyethylene castor oil-20, 30.0% 1,3-butanediol, 5% vitamin E, 13.9% isopropyl myristate, 43.0% glycerin in a water bath at 35 °C Dissolved to obtain the oil phase, set aside;

[0040] Add 0.1% kaempferol to the oil phase, stir in a water bath at 35°C at a speed of 15 rpm for 10 minutes, and then let it stand for 1 minute to obtain the kaempferol nano composition.

[0041] The particle diameter of the kaempferol nanocomposition is detected, and the particle diameter of the kaempferol nanocomposition is 15.1 nm.

Embodiment 2

[0043] 2.0% Tween 40, 6.0% polyoxyethylene castor oil-30, 5% polyethylene glycol 400 monoglyceride, 20.0% dipropylene glycol, 7.0% 1,2-hexanediol, 10.0% isopropyl palmitate , 5.0% caprylic capric acid macrogol glyceride and 32.0% glycerin were dissolved in a water bath at 50°C to obtain an oil phase for subsequent use;

[0044] Add 1.0% kaempferol to the oil phase, stir in a water bath at 50° C. at a speed of 30 rpm for 10 minutes, and then let stand for 2 minutes to obtain the kaempferol nano composition.

[0045] The particle diameter of the kaempferol nanocomposition is detected, and the particle diameter of the kaempferol nanocomposition is 25.0 nm.

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Abstract

The invention provides a kaempferol nanometer composition, and belongs to the field of cosmetics. The kaempferol nanometer composition is prepared from, by mass percent, 0.1-10.0% of kaempferol, 8.0-70.0% of emulgator, 10.0-30.0% of co-emulsifier, 1.0-15.0% of liquid lipid, and 5.0-45.0% of polyhydric alcohols. In the invention, the emulsifier, the co-emulsifier, the liquid lipid, and the polyhydric alcohols are formed to be a homogeneous phase dispersing system with stable thermodynamics; thus the kaempferol nanometer composition is good in stability, quick in skin absorption, good in permeability, and excellent in biocompatibility; the synergistic effect of the emulsifier and the co-emulsifier can stabilize the active matter kaempferol; the provided kaempferol nanometer composition is big in drug carrying capacity, and the concentration of the kaempferol carrying with more active matters is up to 10.0%; the kaempferol nanometer composition used as a transdermal storage base can continuously release kaempferol, maintain effective concentration for a long time, inhibit 5 alpha-reductase activity better, and display the antibiosis and anti-oxidizing effects.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a kaempferol nano composition, a preparation method and application thereof. Background technique [0002] Kaempferol belongs to flavonols, derived from the rhizome of Zingiberaceae kaempferen, the root of Berberidaceae plant Woerqi, the whole grass of Sandalaceae plant Bai Ruicao, the aerial part of Euphorbiaceae plant cat's eye grass, and the dry mature fruit of leguminous plant Sophora japonica . Studies have shown that kaempferol has inhibitory 5α-reductase, antibacterial and other activities, and has inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa, typhoid bacillus, and Shigella. It can be compounded with other antibacterial agents for cosmetic antiseptic. Antioxidant effect, antibacterial and antioxidative effect at the same time. In addition, it can also be used for anti-cancer, anti-epilepsy, protection of nerve cells, antispasmodic, anti-ulcer, ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/34A61K8/06A61Q17/00A61Q19/00A61Q19/08A61P35/00A61P7/02A61P1/16
CPCA61K8/498A61K8/068A61K8/345A61K2800/413A61K2800/72A61K2800/782A61Q17/005A61Q19/00A61Q19/08
Inventor 刘卫陈家铃许琦闻庆石丛姣杨达峰
Owner WUHAN BEST CARRIER NANO TECH
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